Position Paper
Cardiac implantable electronic and other monitoring devices in continuous-flow left ventricular assist device patients. A clinical consensus statement of the Heart Failure Association and the European Heart Rhythm Association of the ESC
Offer Amir,
Stamatis Adamopoulos,
Haran Burri,
Antoni Bayes-Genis,
Christophe Leclercq,
Maja Cikes,
Anastasia Egorova,
Petr Peichl,
Marat Fudim,
Archana Rao,
Finn Gustafsson,
Sergio Richter,
Matteo Pagnesi,
Giuseppe Rosano,
Frank Ruschitzka,
Jens Cosedis Nielsen,
Corresponding Author
Offer Amir
Heart Institute, Hadassah University Medical Center and Faculty of Medicine, Hebrew University, Jerusalem, Israel
Corresponding author. Heart Institute, Hadassah University Medical Center and Faculty of Medicine, Hebrew University, Jerusalem, Israel. Tel: +972 2 6775266, Fax: +972 2 6775270, Email: [email protected]
Search for more papers by this authorStamatis Adamopoulos
Heart Failure-Heart Transplant-Mechanical Circulatory Support Unit, Onassis Cardiac Surgery Center, Athens, Greece
Search for more papers by this authorHaran Burri
Cardiac Pacing Unit, Cardiology Department, University Hospital of Geneva, Geneva, Switzerland
Search for more papers by this authorAntoni Bayes-Genis
Institut del Cor Germans Trias i Pujol, CIBERCV, Barcelona, Spain
Search for more papers by this authorChristophe Leclercq
Department of Cardiology, University Rennes, Rennes, France
Search for more papers by this authorMaja Cikes
University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Zagreb, Croatia
Search for more papers by this authorAnastasia Egorova
CAHAL, Center for Congenital Heart Disease Amsterdam Leiden, Leiden University Medical Center, Leiden, The Netherlands
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Search for more papers by this authorPetr Peichl
Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Search for more papers by this authorMarat Fudim
Division of Cardiology, Department of Medicine, Duke University, Durham, NC, USA
Duke Clinical Research Institute, Durham, NC, USA
Search for more papers by this authorArchana Rao
PG Dip Cardiology, GPSI Cardiology, Liverpool Heart and Chest Hospital, Liverpool, UK
Search for more papers by this authorFinn Gustafsson
Department of Cardiology, Rigshospitalet, University of Copenhagen, København, Denmark
Search for more papers by this authorSergio Richter
Department of Cardiology, Heart Center Dresden, University Hospital, Technischen Universität Dresden, Dresden, Germany
Search for more papers by this authorMatteo Pagnesi
Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
Search for more papers by this authorGiuseppe Rosano
Chair of Pharmacology, Department of Human Sciences and Promotion of Quality of Life, San Raffaele University of Rome, Rome, Italy
Department of Cardiology, San Raffaele Cassino Hospital, Cassino, Italy
Search for more papers by this authorFrank Ruschitzka
Department of Cardiology, University Heart Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland
Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
Search for more papers by this authorJens Cosedis Nielsen
Department of Cardiology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Search for more papers by this authorOffer Amir,
Stamatis Adamopoulos,
Haran Burri,
Antoni Bayes-Genis,
Christophe Leclercq,
Maja Cikes,
Anastasia Egorova,
Petr Peichl,
Marat Fudim,
Archana Rao,
Finn Gustafsson,
Sergio Richter,
Matteo Pagnesi,
Giuseppe Rosano,
Frank Ruschitzka,
Jens Cosedis Nielsen,
Corresponding Author
Offer Amir
Heart Institute, Hadassah University Medical Center and Faculty of Medicine, Hebrew University, Jerusalem, Israel
Corresponding author. Heart Institute, Hadassah University Medical Center and Faculty of Medicine, Hebrew University, Jerusalem, Israel. Tel: +972 2 6775266, Fax: +972 2 6775270, Email: [email protected]
Search for more papers by this authorStamatis Adamopoulos
Heart Failure-Heart Transplant-Mechanical Circulatory Support Unit, Onassis Cardiac Surgery Center, Athens, Greece
Search for more papers by this authorHaran Burri
Cardiac Pacing Unit, Cardiology Department, University Hospital of Geneva, Geneva, Switzerland
Search for more papers by this authorAntoni Bayes-Genis
Institut del Cor Germans Trias i Pujol, CIBERCV, Barcelona, Spain
Search for more papers by this authorChristophe Leclercq
Department of Cardiology, University Rennes, Rennes, France
Search for more papers by this authorMaja Cikes
University of Zagreb School of Medicine, Department of Cardiovascular Diseases, University Hospital Center Zagreb, Zagreb, Croatia
Search for more papers by this authorAnastasia Egorova
CAHAL, Center for Congenital Heart Disease Amsterdam Leiden, Leiden University Medical Center, Leiden, The Netherlands
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Search for more papers by this authorPetr Peichl
Institute for Clinical and Experimental Medicine, Prague, Czech Republic
Search for more papers by this authorMarat Fudim
Division of Cardiology, Department of Medicine, Duke University, Durham, NC, USA
Duke Clinical Research Institute, Durham, NC, USA
Search for more papers by this authorArchana Rao
PG Dip Cardiology, GPSI Cardiology, Liverpool Heart and Chest Hospital, Liverpool, UK
Search for more papers by this authorFinn Gustafsson
Department of Cardiology, Rigshospitalet, University of Copenhagen, København, Denmark
Search for more papers by this authorSergio Richter
Department of Cardiology, Heart Center Dresden, University Hospital, Technischen Universität Dresden, Dresden, Germany
Search for more papers by this authorMatteo Pagnesi
Institute of Cardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy
Search for more papers by this authorGiuseppe Rosano
Chair of Pharmacology, Department of Human Sciences and Promotion of Quality of Life, San Raffaele University of Rome, Rome, Italy
Department of Cardiology, San Raffaele Cassino Hospital, Cassino, Italy
Search for more papers by this authorFrank Ruschitzka
Department of Cardiology, University Heart Center, University Hospital Zurich and University of Zurich, Zurich, Switzerland
Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
Search for more papers by this authorJens Cosedis Nielsen
Department of Cardiology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Search for more papers by this authorAbstract
The management of heart failure patients with continuous-flow left ventricular assist device (LVAD) patients is challenging. While one third of these patients are recipients of cardiac implantable electronic devices (CIEDs), the risk for atrial and ventricular arrhythmias may coexist. The lack of large datasets and dedicated randomized controlled trials (RCTs) focusing on LVAD and CIED implantation and management has brought medical centres to develop their own protocols and guidelines. This clinical consensus statement of the Heart Failure Association and the European Heart Rhythm Association of the ESC is a joint effort to summarize the current literature and provide advice on patient management within this field.
References
- 1Glikson M, Nielsen JC, Kronborg MB, Michowitz Y, Auricchio A, Barbash IM, et al. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy. Eur Heart J 2021; 42: 3427–3520. https://doi.org/10.1093/eurheartj/ehab364
- 2Mehra MR, Naka Y, Uriel N, Goldstein DJ, Cleveland JC Jr, Colombo PC, et al.; MOMENTUM 3 Investigators. A fully magnetically levitated circulatory pump for advanced heart failure. N Engl J Med 2017; 376: 440–450. https://doi.org/10.1056/NEJMoa1610426
- 3Rogers JG, Pagani FD, Tatooles AJ, Bhat G, Slaughter MS, Birks EJ, et al. Intrapericardial left ventricular assist device for advanced heart failure. N Engl J Med 2017; 376: 451–460. https://doi.org/10.1056/NEJMoa1602954
- 4Kociol RD. Time for MADIT-VAD?: ICDs among LVAD patients. JACC Heart Fail 2016; 4: 780–782. https://doi.org/10.1016/j.jchf.2016.08.003
- 5Harding JD, Piacentino V 3rd, Gaughan JP, Houser SR, Margulies KB. Electrophysiological alterations after mechanical circulatory support in patients with advanced cardiac failure. Circulation 2001; 104: 1241–1247. https://doi.org/10.1161/hc3601.095718
- 6Fukunaga N, Nedadur R, Badiwala MV, Billia F, McDonald MA, Rao V. Ventricular standstill in a patient with a left ventricular assist device. Ann Thorac Surg 2019; 108:e153-e155. https://doi.org/10.1016/j.athoracsur.2019.01.066
- 7Alvarez PA, Sperry BW, Perez AL, Yaranov DM, Randhawa V, Luthman J, et al. Implantable cardioverter defibrillators in patients with continuous flow left ventricular assist devices: Utilization patterns, related procedures, and complications. J Am Heart Assoc 2019; 8:e011813. https://doi.org/10.1161/JAHA.118.011813
- 8Tehrani DM, Adatya S, Grinstein J, Rodgers D, Sarswat N, Kim GH, et al. Impact of cardiac resynchronization therapy on left ventricular unloading in patients with implanted left ventricular assist devices. ASAIO J 2019; 65: 117–122. https://doi.org/10.1097/MAT.0000000000000787
- 9Darden D, Ammirati E, Brambatti M, Lin A, Hsu JC, Shah P, et al. Cardiovascular implantable electronic device therapy in patients with left ventricular assist devices: Insights from TRAViATA. Int J Cardiol 2021; 340: 26–33. https://doi.org/10.1016/j.ijcard.2021.08.033
- 10Molina EJ, Shah P, Kiernan MS, Cornwell WK 3rd, Copeland H, Takeda K, et al. The Society of Thoracic Surgeons Intermacs 2020 annual report. Ann Thorac Surg 2021; 111: 778–792. https://doi.org/10.1016/j.athoracsur.2020.12.038
- 11Zuk K, Gahl B, Susac M, Vierecke J, de By TMMH, Windecker S, et al. Mid-term mechanical circulatory support: Comparison of single-centre data with the EUROMACS registry. Eur J Cardiothorac Surg 2017; 51: 127–134. https://doi.org/10.1093/ejcts/ezw256
- 12Migliore F, Schiavone M, Pittorru R, Forleo GB, de Lazzari M, Mitacchione G, et al. Left ventricular assist device in the presence of subcutaneous implantable cardioverter defibrillator: Data from a multicenter experience. Int J Cardiol 2024; 400:131807. https://doi.org/10.1016/j.ijcard.2024.131807
- 13Friedman P, Murgatroyd F, Boersma LVA, Manlucu J, O'Donnell D, Knight BP, et al.; Extravascular ICD Pivotal Study Investigators. Efficacy and safety of an extravascular implantable cardioverter-defibrillator. N Engl J Med 2022; 387: 1292–1302. https://doi.org/10.1056/NEJMoa2206485
- 14Galand V, Flecher E, Auffret V, Boulé S, Vincentelli A, Dambrin C, et al.; ASSIST-ICD Investigators. Predictors and clinical impact of late ventricular arrhythmias in patients with continuous-flow left ventricular assist devices. JACC Clin Electrophysiol 2018; 4: 1166–1175. https://doi.org/10.1016/j.jacep.2018.05.006
- 15Wann DG, Baird AS, Wang NC, Mulukutla SR, Thoma FW, Sezer A, et al. Association of pre-left ventricular assist device defibrillator shocks for ventricular arrhythmia with clinical outcomes after left ventricular assist device implantation. Heart Rhythm O2 2023; 4: 708–714. https://doi.org/10.1016/j.hroo.2023.10.002
- 16Cikes M, Jakus N, Claggett B, Brugts JJ, Timmermans P, Pouleur A-C, et al. Cardiac implantable electronic devices with a defibrillator component and all-cause mortality in left ventricular assist device carriers: Results from the PCHF-VAD registry. Eur J Heart Fail 2019; 21: 1129–1141. https://doi.org/10.1002/ejhf.1568
- 17Pausch J, Mersmann J, Bhadra OD, Barten MJ, Tönnis T, Yildirim Y, et al. Prognostic impact of implantable cardioverter defibrillators and associated adverse events in patients with continuous flow left ventricular assist devices. Front Cardiovasc Med 2023; 10:1158248. https://doi.org/10.3389/fcvm.2023.1158248
- 18Chung BB, Grinstein JS, Imamura T, Kruse E, Nguyen AB, Narang N, et al. Biventricular pacing versus right ventricular pacing in patients supported with LVAD. JACC Clin Electrophysiol 2021; 7: 1003–1009. https://doi.org/10.1016/j.jacep.2021.01.016
- 19Gilge JL, Sbircea N, Tong MZ, Bauza K, Cantillon DJ, Srivastava A, et al. Incidence of cardiac implantable electronic device complications in patients with left ventricular assist devices. JACC Clin Electrophysiol 2021; 7: 494–501. https://doi.org/10.1016/j.jacep.2020.09.008
- 20Black-Maier E, Lewis RK, Loungani R, Rehorn M, Friedman DJ, Bishawi M, et al. Cardiovascular implantable electronic device surgery following left ventricular assist device implantation. JACC Clin Electrophysiol 2020; 6: 1131–1139. https://doi.org/10.1016/j.jacep.2020.04.030
- 21Eulert-Grehn JJ, Sterner I, Schoenrath F, Stein J, Mulzer J, Kurz S, et al. Defibrillator generator replacements in patients with left ventricular assist device support: The risks of hematoma and infection. J Heart Lung Transplant 2022; 41: 810–817. https://doi.org/10.1016/j.healun.2022.02.013
- 22Mehra MR, Netuka I, Uriel N, Katz JN, Pagani FD, Jorde UP, et al.; ARIES-HM3 Investigators. Aspirin and hemocompatibility events with a left ventricular assist device in advanced heart failure: The ARIES-HM3 randomized clinical trial. JAMA 2023; 330: 2171–2181. https://doi.org/10.1001/jama.2023.23204
- 23Migliore F, Leoni L, Bottio T, Siciliano M, Ferretto S, Gerosa G, et al. Subcutaneous implantable cardioverter-defibrillator and left ventricular assist device: A safe and effctive approach for refractory heart failure. JACC Clin Electrophysiol 2016; 2: 246–247. https://doi.org/10.1016/j.jacep.2015.10.008
- 24Smietana J, Schell A, Pothineni NVK, Walsh K, Lin D. A left ventricular assist device interfering with leadless pacemaker implantation. Pacing Clin Electrophysiol 2021; 44: 1949–1951. https://doi.org/10.1111/pace.14332
- 25Gopinathannair R, Cornwell WK, Dukes JW, Ellis CR, Hickey KT, Joglar JA, et al. Device therapy and arrhythmia management in left ventricular assist device recipients: A scientific statement from the American Heart Association. Circulation 2019; 139:e967-e989. https://doi.org/10.1161/CIR.0000000000000673
- 26Richardson TD, Hale L, Arteaga C, Xu M, Keebler M, Schlendorf K, et al. Prospective randomized evaluation of implantable cardioverter-defibrillator programming in patients with a left ventricular assist device. J Am Heart Assoc 2018; 7:e007748. https://doi.org/10.1161/JAHA.117.007748
- 27Vakil K, Kazmirczak F, Sathnur N, Adabag S, Cantillon DJ, Kiehl EL, et al. Implantable cardioverter-defibrillator use in patients with left ventricular assist devices: A systematic review and meta-analysis. JACC Heart Fail 2016; 4: 772–779. https://doi.org/10.1016/j.jchf.2016.05.003
- 28Parikh V, Sauer A, Friedman PA, Sheldon SH. Management of cardiac implantable electronic devices in the presence of left ventricular assist devices. Heart Rhythm 2018; 15: 1089–1096. https://doi.org/10.1016/j.hrthm.2018.01.017
- 29Tanawuttiwat T, Das MK, Miller JM, Guglin ME. Device-device interaction between cardiac implantable electronic devices and continuous-flow left ventricular assist devices. Heart Rhythm 2023; 20: 918–926. https://doi.org/10.1016/j.hrthm.2023.02.020
- 30Martins RP, Leclercq C, Bourenane H, Auffret V, Boulé S, Loobuyck V, et al. Incidence, predictors, and clinical impact of electrical storm in patients with left ventricular assist devices: New insights from the ASSIST-ICD study. Heart Rhythm 2019; 16: 1506–1512. https://doi.org/10.1016/j.hrthm.2019.06.021
- 31Rehorn MR, Black-Maier E, Loungani R, Sen S, Sun AY, Friedman DJ, et al. Electrical storm in patients with left ventricular assist devices: Risk factors, incidence, and impact on survival. Heart Rhythm 2021; 18: 1263–1271. https://doi.org/10.1016/j.hrthm.2021.03.047
- 32Sweeney MO, Ruetz LL, Belk P, Mullen TJ, Johnson JW, Sheldon T. Bradycardia pacing-induced short-long-short sequences at the onset of ventricular tachyarrhythmias: A possible mechanisms of proarrhythmia? J Am Coll Cardiol 2007; 50: 614–622. https://doi.org/10.1016/j.jacc.2007.02.077
- 33Chou A, Larson J, Deshmukh A, Cascino TM, Ghannam M, Latchamsetty R, et al. Association between biventricular pacing and incidence of ventricular arrhythmias in the early post-operative period after left ventricular assist device implantation. J Cardiovasc Electrophysiol 2022; 33: 1024–1031. https://doi.org/10.1111/jce.15437
- 34Schleifer JW, Mookadam F, Kransdorf EP, Nanda U, Adams JC, Cha S, et al. Effect of continued cardiac resynchronization therapy on ventricular arrhythmias after left ventricular assist device implantation. Am J Cardiol 2016; 118: 556–559. https://doi.org/10.1016/j.amjcard.2016.05.050
- 35Berg DD, Vaduganathan M, Upadhyay GA, Singh JP, Mehra MR, Stewart GC. Cardiac implantable electronic devices in patients with left ventricular assist systems. J Am Coll Cardiol 2018; 71: 1483–1493. https://doi.org/10.1016/j.jacc.2018.01.061
- 36Kirkfeldt RE, Johansen JB, Nøhr EA, Jørgensen OD, Nielsen JC. Complications after cardiac implantable electronic device implantations: An analysis of a complete, nationwide cohort in Denmark. Eur Heart J 2014; 35: 1186–1194. https://doi.org/10.1093/eurheartj/eht511
- 37Palmisano P, Guerra F, Dell'Era G, Dell'Era G, Ammendola E, Ziacchi M, et al.; Italian Association of Arrhythmology and Cardiac Pacing (AIAC). Impact on all-cause and cardiovascular mortality of cardiac implantable electronic device complications: Results from the POINTED Registry. JACC Clin Electrophysiol 2020; 6: 382–392. https://doi.org/10.1016/j.jacep.2019.11.005
- 38Ravichandran A, Pothineni NVK, Trivedi JR, Roukoz H, Ahmed MM, Bhan A, et al. Implantable cardioverter-defibrillator-related procedures and associated complications in continuous flow left ventricular assist device recipients: A multicenter experience. Heart Rhythm O2 2021; 2: 691–697. https://doi.org/10.1016/j.hroo.2021.09.005
- 39Riaz T, Nienaber JJ, Baddour LM, Nienaber JJC, Walker RC, Park SJ, et al. Cardiovascular implantable electronic device infections in left ventricular assist device recipients. Pacing Clin Electrophysiol 2014; 37: 225–230. https://doi.org/10.1111/pace.12240
- 40Galand V, Leclercq C, Boule S, Mondoly P, Ploux S, Defaye P, et al. Implantable cardioverter- defibrillator interference after LVAD implantation. JACC Clin Electrophysiol 2020; 6: 1315–1317. https://doi.org/10.1016/j.jacep.2020.05.039
- 41Galand V, Leclercq C, Bourenane H, Boulé S, Vincentelli A, Maury P, et al. Implantable cardiac defibrillator leads dysfunction after LVAD implantation. Pacing Clin Electrophysiol 2020; 43: 1309–1317. https://doi.org/10.1111/pace.14004
- 42Blomstrom-Lundqvist C, Traykov V, Erba PA, et al. European Heart Rhythm Association (EHRA) international consensus document on how to prevent, diagnose, and treat cardiac implantable electronic device infections-endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), the Latin American Heart Rhythm Society (LAHRS), International Society for Cardiovascular Infectious Diseases (ISCVID) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS). Europace 2020; 22: 515–549. https://doi.org/10.1093/europace/euz246
- 43Baddour LM, Esquer Garrigos Z, Rizwan Sohail M, Havers-Borgersen E, Krahn AD, Chu VH, et al. Update on cardiovascular implantable electronic device infections and their prevention, diagnosis, and management: A scientific statement from the American Heart Association: Endorsed by the International Society for Cardiovascular Infectious Diseases. Circulation 2024; 149: e201–e216. https://doi.org/10.1161/CIR.0000000000001187
- 44Black-Maier E, Piccini JP, Bishawi M, Pokorney SD, Bryner B, Schroder JN, et al. Lead extraction for cardiovascular implantable electronic device infection in patients with left ventricular assist devices. JACC Clin Electrophysiol 2020; 6: 672–680. https://doi.org/10.1016/j.jacep.2020.02.006
- 45Krishnamoorthy A, Pokorney SD, Lewis RK, Daubert JP, Greenfield RA, Hegland DD, et al. Cardiac implantable electronic device removal in patients with left ventricular assist device associated infections. J Cardiovasc Electrophysiol 2014; 25: 1199–1205. https://doi.org/10.1111/jce.12461
- 46Tattevin P, Flecher E, Auffret V, Leclercq C, Boulé S, Vincentelli A, et al. Risk factors and prognostic impact of left ventricular assist device-associated infections. Am Heart J 2019; 214: 69–76. https://doi.org/10.1016/j.ahj.2019.04.021
- 47Addetia K, Harb SC, Hahn RT, Kapadia S, Lang RM. Cardiac implantable electronic device lead-induced tricuspid regurgitation. JACC Cardiovasc Imaging 2019; 12: 622–636. https://doi.org/10.1016/j.jcmg.2018.09.028
- 48Andreas M, Burri H, Praz F, Soliman O, Badano L, Barreiro M, et al. Tricuspid valve disease and cardiac implantable electronic devices. Eur Heart J 2024; 45: 346–365. https://doi.org/10.1093/eurheartj/ehad783
- 49Kapelios CJ, Lund LH, Wever-Pinzon O, Selzman CH, Myers SL, Cantor RS, et al. Right heart failure following left ventricular device implantation: Natural history, risk factors, and outcomes: An analysis of the STS INTERMACS database. Circ Heart Fail 2022; 15:e008706. https://doi.org/10.1161/CIRCHEARTFAILURE.121.008706
- 50Rajapreyar I, Soliman O, Brailovsky Y, Tedford RJ, Gibson G, Mohacsi P, et al. Late right heart failure after left ventricular assist device implantation: Contemporary insights and future perspectives. JACC Heart Fail 2023; 11: 865–878. https://doi.org/10.1016/j.jchf.2023.04.014
- 51Bongiorni MG, Kennergren C, Butter C, Deharo JC, Kutarski A, Rinaldi CA, et al.; ELECTRa Investigators. The European Lead Extraction ConTRolled (ELECTRa) study: A European Heart Rhythm Association (EHRA) registry of transvenous lead extraction outcomes. Eur Heart J 2017; 38: 2995–3005. https://doi.org/10.1093/eurheartj/ehx080
- 52Parkash R, Thibault B, Mangat I, Coutu B, Bennett M, Healey J, et al. Canadian registry of implantable electronic device outcomes: Surveillance of the Riata lead under advisory. Circ Arrhythm Electrophysiol 2016; 9:e004282. https://doi.org/10.1161/CIRCEP.116.004282
- 53Sood N, Martin DT, Lampert R, Curtis JP, Parzynski C, Clancy J. Incidence and predictors of perioperative complications with transvenous lead extractions: Real-world experience with National Cardiovascular Data Registry. Circ Arrhythm Electrophysiol 2018; 11:e004768. https://doi.org/10.1161/CIRCEP.116.004768
- 54Kusumoto FM, Schoenfeld MH, Wilkoff BL, Berul CI, Birgersdotter-Green UM, Carrillo R, et al. 2017 HRS expert consensus statement on cardiovascular implantable electronic device lead management and extraction. Heart Rhythm 2017; 14: e503–e551. https://doi.org/10.1016/j.hrthm.2017.09.001
- 55Oz MC, Rose EA, Slater J, Kuiper JJ, Catanese KA, Levin HR. Malignant ventricular arrhythmias are well tolerated in patients receiving long-term left ventricular assist devices. J Am Coll Cardiol 1994; 24: 1688–1691. https://doi.org/10.1016/0735-1097(94)90175-9
- 56Makki N, Mesubi O, Steyers C, Olshansky B, Abraham WT. Meta-analysis of the relation of ventricular arrhythmias to all-cause mortality after implantation of a left ventricular assist device. Am J Cardiol 2015; 116: 1385–1390. https://doi.org/10.1016/j.amjcard.2015.07.065
- 57Nakahara S, Chien C, Gelow J, Dalouk K, Henrikson CA, Mudd J, et al. Ventricular arrhythmias after left ventricular assist device. Circ Arrhythm Electrophysiol 2013; 6: 648–654. https://doi.org/10.1161/circep.113.000113
- 58Yoruk A, Sherazi S, Massey HT, Kutyifa V, McNitt S, Hallinan W, et al. Predictors and clinical relevance of ventricular tachyarrhythmias in ambulatory patients with a continuous flow left ventricular assist device. Heart Rhythm 2016; 13: 1052–1056. https://doi.org/10.1016/j.hrthm.2016.01.033
- 59Zeppenfeld K, Tfelt-Hansen J, de Riva M, Winkel BG, Behr ER, Blom NA, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J 2022; 43: 3997–4126. https://doi.org/10.1093/eurheartj/ehac262
- 60Cotarlan V, Johnson F, Goerbig-Campbell J, Light-McGroary KA, Inampudi C, Franzwa J, et al. Usefulness of cardiac resynchronization therapy in patients with continuous flow left ventricular assist devices. Am J Cardiol 2019; 123: 93–99. https://doi.org/10.1016/j.amjcard.2018.09.022
- 61Gulletta S, Scandroglio AM, Pannone L, Falasconi G, Melisurgo G, Ajello S, et al. Clinical characteristics and outcomes of patients with ventricular arrhythmias after continuous-flow left ventricular assist device implant. Artif Organs 2022; 46: 1608–1615. https://doi.org/10.1111/aor.14234
- 62Al Jebaje Z, Wu Z, McNitt S, Vidula H, Chen L, Alexis J, et al. Outcomes and complications of cardiac resynchronization therapy in patients with continuous-flow left ventricular assist devices. Heart Rhythm 2021; 18: S45. https://doi.org/10.1016/j.hrthm.2021.06.132
10.1016/j.hrthm.2021.06.132 Google Scholar
- 63Jorde UP, Saeed O, Koehl D, Morris AA, Wood KL, Meyer DM, et al. The Society of Thoracic Surgeons Intermacs 2023 annual report: Focus on magnetically levitated devices. Ann Thorac Surg 2024; 117: 33–44. https://doi.org/10.1016/j.athoracsur.2023.11.004
- 64Topkara VK, Garan AR, Fine B, Godier-Furnémont AF, Breskin A, Cagliostro B, et al. Myocardial recovery in patients receiving contemporary left ventricular assist devices: Results from the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS). Circ Heart Fail 2016; 9:e003157. https://doi.org/10.1161/CIRCHEARTFAILURE.116.003157
- 65Antonides CFJ, Schoenrath F, de By TMMH, Muslem R, Veen K, Yalcin YC, et al.; EUROMACS Investigators. Outcomes of patients after successful left ventricular assist device explantation: A EUROMACS study. ESC Heart Fail 2020; 7: 1085–1094. https://doi.org/10.1002/ehf2.12629
- 66Basuray A, French B, Ky B, Vorovich E, Olt C, Sweitzer NK, et al. Heart failure with recovered ejection fraction: Clinical description, biomarkers, and outcomes. Circulation 2014; 129: 2380–2387. https://doi.org/10.1161/CIRCULATIONAHA.113.006855
- 67Gopinathannair R, Birks EJ, Trivedi JR, McCants KC, Sutton BS, Deam AG, et al. Impact of cardiac resynchronization therapy on clinical outcomes in patients with continuous-flow left ventricular assist devices. J Card Fail 2015; 21: 226–232. https://doi.org/10.1016/j.cardfail.2014.12.006
- 68Gopinathannair R, Roukoz H, Bhan A, Ravichandran A, Ahmed MM, Familtsev D, et al. Cardiac resynchronization therapy and clinical outcomes in continuous flow left ventricular assist device recipients. J Am Heart Assoc 2018; 7:e009091. https://doi.org/10.1161/JAHA.118.009091
- 69Parthiban N, Esterman A, Mahajan R, Twomey DJ, Pathak RK, Lau DH, et al. Remote monitoring of implantable cardioverter-defibrillators: A systematic review and meta-analysis of clinical outcomes. J Am Coll Cardiol 2015; 65: 2591–2600. https://doi.org/10.1016/j.jacc.2015.04.029
- 70Agarwal S, Ul Abideen Asad Z, Akella K, Clifton S, Trivedi J, Pothineni NV, et al. Meta-analysis on the impact of ventricular arrhythmias on mortality in patients with continuous flow left ventricular assist devices. Am J Cardiol 2023; 192: 139–146. https://doi.org/10.1016/j.amjcard.2023.01.026
- 71Moazeni M, Numan L, Szymanski MK, van der Kaaij NP, Asselbergs FW, van Laake LW, et al. Monitoring left ventricular assist device parameters to detect flow- and power-impacting complications: A proof of concept. Eur Heart J Digit Health 2023; 4: 488–495. https://doi.org/10.1093/ehjdh/ztad062
- 72Thohan V, Abraham J, Burdorf A, Sulemanjee N, Jaski B, Guglin M, et al.; INTELLECT 2-HF Investigators. Use of a pulmonary artery pressure sensor to manage patients with left ventricular assist devices. Circ Heart Fail 2023; 16:e009960. https://doi.org/10.1161/CIRCHEARTFAILURE.122.009960
- 73Feijen M, Egorova AD, Tops LF, Palmen M, Jukema JW, Schalij MJ, et al. The potential of the HeartLogicTM algorithm in patients with a left ventricular assist device, an initial report. J Cardiovasc Dev Dis 2024; 11:51. https://doi.org/10.3390/jcdd11020051
- 74Lerman JB, Cyr DD, Chiswell K, Tobin RS, Fudim M, Pokorney SD, et al. The use of the multisensor HeartLogic algorithm for heart failure remote monitoring in patients with left ventricular assist devices. ASAIO J 2023; 69: e351–e353. https://doi.org/10.1097/MAT.0000000000001946
- 75McIlvennan CK, Grady KL, Matlock DD, Helmkamp LJ, Abshire M, Allen LA. End of life for patients with left ventricular assist devices: Insights from INTERMACS. J Heart Lung Transplant 2019; 38: 374–381. https://doi.org/10.1016/j.healun.2018.12.008
- 76Dunlay SM, Strand JJ, Wordingham SE, Stulak JM, Luckhardt AJ, Swetz KM. Dying with a left ventricular assist device as destination therapy. Circ Heart Fail 2016; 9:e003096. https://doi.org/10.1161/CIRCHEARTFAILURE.116.003096
- 77Padeletti L, Arnar DO, Boncinelli L, Brachman J, Camm JA, Daubert JC, et al. EHRA expert consensus statement on the management of cardiovascular implantable electronic devices in patients nearing end of life or requesting withdrawal of therapy. Europace 2010; 12: 1480–1489. https://doi.org/10.1093/europace/euq275
- 78Agrawal S, Garg L, Nanda S, Sharma A, Bhatia N, Manda Y, et al. The role of implantable cardioverter-defibrillators in patients with continuous flow left ventricular assist devices – a meta-analysis. Int J Cardiol 2016; 222: 379–384. https://doi.org/10.1016/j.ijcard.2016.07.257
- 79Clerkin KJ, Topkara VK, Demmer RT, Dizon JM, Yuzefpolskaya M, Fried JA, et al. Implantable cardioverter-defibrillators in patients with a continuous-flow left ventricular assist device: An analysis of the INTERMACS Registry. JACC Heart Fail 2017; 5: 916–926. https://doi.org/10.1016/j.jchf.2017.08.014
- 80Kelley AS, Mehta SS, Reid MC. Management of patients with ICDs at the end of life (EOL): A qualitative study. Am J Hosp Palliat Care 2008; 25: 440–446. https://doi.org/10.1177/1049909108320885
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