Volume 52, Issue 10 pp. 5390-5402
ORIGINAL ARTICLE

Construction of logic circuit with modular molecular switching strategy based on DNA strand displacement

Chun Huang

Chun Huang

College of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, China

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Jiaying Shao

Jiaying Shao

College of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, China

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Yifei Guo

Yifei Guo

College of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, China

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Junying Yao

Junying Yao

College of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, China

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Baolei Peng

Baolei Peng

College of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, China

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Qingshuang Guo

Qingshuang Guo

College of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, China

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Junwei Sun

Junwei Sun

College of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, China

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Xuncai Zhang

Xuncai Zhang

College of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, China

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Yanfeng Wang

Corresponding Author

Yanfeng Wang

College of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou, China

Correspondence

Yanfeng Wang, College of Electrical and Information Engineering, Zhengzhou University of Light Industry, Zhengzhou 450002, China.

Email: [email protected]

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First published: 01 April 2024

Summary

At present, many DNA logic circuits have been successfully constructed. However, advanced complex DNA computing tasks with simple structure, fast response, and modularization still remain a huge challenge. In this paper, molecular switch circuits (MSCs) are constructed based on DNA strand displacement to improve above problems. At first, molecular switch is constructed, which is the basic element for building logic circuits. Next, the functions of AND, OR, Fan-in, and Fan-out are realized through switches cascading in series or parallel. Furthermore, switch canvas strategy is explored to obtain the shortest reaction path and highest output concentration for circuits. Finally, a novel strategy of integrating computing module using molecular switches is proposed. Here, we construct a half-adder, half-subtractor, and a 9-bit parity checking circuits to verify its feasibility. Compared with the classical monorail and dual-track logic circuits, the structure scale is reduced by more than two times, and the DNA strands are decreased by more than four times, which effectively reduces the circuit complexity and raises the reaction speed. The above results show that MSC strategy has a great potential to construct large-scale DNA circuits and provides a development model for the scalability and modularity of biological computing.

DATA AVAILABILITY STATEMENT

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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