Structurally Interesting Diarymethane Derivatives from Securidaca inappendiculata
Bin Zhou
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203 China
Search for more papers by this authorYan Wu
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203 China
Search for more papers by this authorLishe Gan
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058 China
Search for more papers by this authorSeema Dalal
Department of Biochemistry, MC 0308, Virginia Tech, Blacksburg, Virginia 24061, United States, Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, Georgia, 30602 United States
Search for more papers by this authorMaria B. Cassera
Department of Biochemistry, MC 0308, Virginia Tech, Blacksburg, Virginia 24061, United States, Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, Georgia, 30602 United States
Search for more papers by this authorCorresponding Author
Jianmin Yue
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203 China
E-mail: [email protected]Search for more papers by this authorBin Zhou
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203 China
Search for more papers by this authorYan Wu
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203 China
Search for more papers by this authorLishe Gan
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058 China
Search for more papers by this authorSeema Dalal
Department of Biochemistry, MC 0308, Virginia Tech, Blacksburg, Virginia 24061, United States, Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, Georgia, 30602 United States
Search for more papers by this authorMaria B. Cassera
Department of Biochemistry, MC 0308, Virginia Tech, Blacksburg, Virginia 24061, United States, Department of Biochemistry and Molecular Biology, and Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, Georgia, 30602 United States
Search for more papers by this authorCorresponding Author
Jianmin Yue
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203 China
E-mail: [email protected]Search for more papers by this authorSummary of main observation and conclusion
Securines A—E, three dimeric diarymethane derivatives (1—3) and two enantiomeric diarymethane derivative monomers (4 and 5), were isolated and characterized from the medicinal plant Securidaca inappendiculata. Compounds 1 and 2 are a pair of enantiomeric diarymethane derivative dimers, and compound 3 is a mesomeric diarymethane derivative dimer. Their structures were determined by a combination of spectroscopic data, X-ray crystallography, electronic circular dichroism (ECD) analysis, and computational ECD calculations. Dimeric compounds 1—3 showed moderate antiplasmodial activities with IC50 values of 0.9, 1.4, and 1.5 μM, respectively.
Supporting Information
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Appendix S1: Supporting Information |
| cjoc202000094-sup-0002-Supinfo.cifPDF document, 1.1 MB |
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| cjoc202000094-sup-0003-Supinfo.cifPDF document, 530.2 KB |
Appendix S3: Supporting Information |
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