Methyl Group in Isocopalane Derivative Showed an Unusual Negative 1H NMR Chemical Shift
Xiong Xiao
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorTianqi Chen
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorFengfeng Zhang
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorJiagao Cheng
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorCorresponding Author
Peiying Wu
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Peiying Wu, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, Fax: 0086-021-64253689
Jiangmeng Ren, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Bubing Zeng, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorCorresponding Author
Jiangmeng Ren
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Peiying Wu, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, Fax: 0086-021-64253689
Jiangmeng Ren, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Bubing Zeng, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorCorresponding Author
Bubing Zeng
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Peiying Wu, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, Fax: 0086-021-64253689
Jiangmeng Ren, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Bubing Zeng, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorXiong Xiao
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorTianqi Chen
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorFengfeng Zhang
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorJiagao Cheng
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorCorresponding Author
Peiying Wu
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Peiying Wu, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, Fax: 0086-021-64253689
Jiangmeng Ren, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Bubing Zeng, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorCorresponding Author
Jiangmeng Ren
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Peiying Wu, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, Fax: 0086-021-64253689
Jiangmeng Ren, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Bubing Zeng, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorCorresponding Author
Bubing Zeng
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
Peiying Wu, School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China, Fax: 0086-021-64253689
Jiangmeng Ren, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Bubing Zeng, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Search for more papers by this authorAbstract
An unusual negative 1H NMR chemical shif of methyl group was discovered in condensation product of isocopalane diterpenoid with p-toluenesulfonyl hydrazide. 2D NMR, computational studies and single-crystal X-ray diffraction analysis showed that the C-20 methyl group was shielded.
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