Silica-supported polyphosphoric acid (PPA-SiO₂) was found to be an efficient catalyst for the multi-component condensation reaction of benzaldehydes, 2-naphthol, and methyl/benzyl carbamate to afford the corresponding N-[α-(β-hydroxy-α-naphthyl)(benzyl)] O-alkyl carbamate derivatives in good to excellent yields. This new approach consistently has the advantage of short reaction time, high conversions, clean reaction profiles, and simple experimental and work-up procedures.

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Volume27, Issue4

April, 2009

Pages 821-824

PPA-SiO₂ Catalyzed Multi-component Synthesis of N-[α-(β-Hydroxy-α-naphthyl)(benzyl)] O-Alkyl Carbamate Derivatives

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PPA-SiO2 Catalyzed Multi-component Synthesis of N-[α-(β-Hydroxy-α-naphthyl)(benzyl)] O-Alkyl Carbamate Derivatives

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PPA-SiO₂ Catalyzed Multi-component Synthesis of N-[α-(β-Hydroxy-α-naphthyl)(benzyl)] O-Alkyl Carbamate Derivatives