Preparation and Enantioselectivity Binding Studies of a New Chiral Cobalt(II)porphyrin-Tröger's Base Conjugate
Ameneh Tatar
Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorMartin Valík
Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorJana Novotná
Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic
Department of Physics and Measurements, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorMartin Havlík
Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorBohumil Dolenský
Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorVladimír Král
Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorMarie Urbanová
Department of Physics and Measurements, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorAmeneh Tatar
Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorMartin Valík
Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorJana Novotná
Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic
Department of Physics and Measurements, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorMartin Havlík
Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorBohumil Dolenský
Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorVladimír Král
Department of Analytical Chemistry, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorMarie Urbanová
Department of Physics and Measurements, Institute of Chemical Technology Prague, Praha, Czech Republic
Search for more papers by this authorABSTRACT
A new bis[cobalt(II)porphyrin]-Tröger's base conjugate was studied as a potential receptor for methyl esters of several amino acids. The conjugate was prepared as racemate, and then resolved via preparative high-performance liquid chromatography (HPLC) on a chiral column. The high affinity to lysine, histidine, and proline methyl esters was found by complexation studies followed by UV-Vis spectroscopy. The studies of pure enantiomers, followed by UV-Vis and electronic circular dichroism spectroscopy, revealed the highest enantioselectivity for lysine methyl ester. Chirality 26:361–367, 2014. © 2014 Wiley Periodicals, Inc.
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