Chemical Constituents from the deep-sea-derived Fungus Aureobasidium melanogenum LUO5
Hao-Yu Dong
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Postgraduate Training Base of Guangzhou University of Chinese Medicine, 518104 Shenzhen, China
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
These authors are contributed equally to this work.
Search for more papers by this authorYuan Wang
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
These authors are contributed equally to this work.
Search for more papers by this authorXiao-Yu Zhang
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Postgraduate Training Base of Guangzhou University of Chinese Medicine, 518104 Shenzhen, China
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorMeng Zhang
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorLong-He Yang
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorZheng-Biao Zou
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorYou Li
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorMing-Min Xie
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorCorresponding Author
Xian-Wen Yang
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorCorresponding Author
Bin Wang
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Postgraduate Training Base of Guangzhou University of Chinese Medicine, 518104 Shenzhen, China
Search for more papers by this authorHao-Yu Dong
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Postgraduate Training Base of Guangzhou University of Chinese Medicine, 518104 Shenzhen, China
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
These authors are contributed equally to this work.
Search for more papers by this authorYuan Wang
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
These authors are contributed equally to this work.
Search for more papers by this authorXiao-Yu Zhang
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Postgraduate Training Base of Guangzhou University of Chinese Medicine, 518104 Shenzhen, China
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorMeng Zhang
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorLong-He Yang
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorZheng-Biao Zou
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorYou Li
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorMing-Min Xie
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorCorresponding Author
Xian-Wen Yang
Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen, 361005 China
Search for more papers by this authorCorresponding Author
Bin Wang
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Postgraduate Training Base of Guangzhou University of Chinese Medicine, 518104 Shenzhen, China
Search for more papers by this authorAbstract
Three new C10 and C12 aliphatic δ-lactones (1–3), three new fatty acid methyl esters (4–6), and eight known compounds (7–14) were isolated from the marine Aureobasidium sp. LUO5. Their structures were established by detailed analyses of the NMR, HRESIMS, optical rotation, and ECD data. All isolates were tested for their inhibitory effects on nitric oxide production in LPS-induced BV-2 cells. Notably, compound 4 displayed the strongest inhibitory effect with the IC50 value of 120.3 nM.
Graphical Abstract
Conflict of interests
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.
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