Synthesis of novel 4,5-dihydropyrrolo[1,2-a]quinoxalines, pyrrolo[1,2-a]quinoxalin]-2-ones and their antituberculosis and anticancer activity
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Erratum: Synthesis of novel 4,5-dihydropyrrolo[1,2-a]quinoxalines, pyrrolo[1,2-a]quinoxalin]-2-ones and their antituberculosis and anticancer activity
- Vitthal B. Makane,
- Eruva Vamshi Krishna,
- Uattam B. Karale,
- Dattatraya A. Babar,
- Saradhi Kalari,
- Estharla M. Rekha,
- Manjulika Shukla,
- Grace Kaul,
- Dharmarajan Sriram,
- Sidharth Chopra,
- Sunil Misra,
- Haridas B. Rode,
- Volume 353Issue 10Archiv der Pharmazie
- First Published online: September 7, 2020
Vitthal B. Makane
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
Search for more papers by this authorEruva Vamshi Krishna
Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Search for more papers by this authorUattam B. Karale
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
Search for more papers by this authorDattatraya A. Babar
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
Search for more papers by this authorSaradhi Kalari
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
Search for more papers by this authorEstharla M. Rekha
Department of Pharmacy, Birla Institute of Technology and Science-Pilani, Hyderabad, Telangana, India
Search for more papers by this authorManjulika Shukla
Department of Microbiology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Search for more papers by this authorGrace Kaul
Department of Microbiology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Search for more papers by this authorDharmarajan Sriram
Department of Pharmacy, Birla Institute of Technology and Science-Pilani, Hyderabad, Telangana, India
Search for more papers by this authorSidharth Chopra
Department of Microbiology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Search for more papers by this authorSunil Misra
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Search for more papers by this authorCorresponding Author
Haridas B. Rode
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
Correspondence Haridas B. Rode, Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, Telangana 500 007, India.
Email: [email protected]
Search for more papers by this authorVitthal B. Makane
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
Search for more papers by this authorEruva Vamshi Krishna
Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Search for more papers by this authorUattam B. Karale
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
Search for more papers by this authorDattatraya A. Babar
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
Search for more papers by this authorSaradhi Kalari
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
Search for more papers by this authorEstharla M. Rekha
Department of Pharmacy, Birla Institute of Technology and Science-Pilani, Hyderabad, Telangana, India
Search for more papers by this authorManjulika Shukla
Department of Microbiology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Search for more papers by this authorGrace Kaul
Department of Microbiology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Search for more papers by this authorDharmarajan Sriram
Department of Pharmacy, Birla Institute of Technology and Science-Pilani, Hyderabad, Telangana, India
Search for more papers by this authorSidharth Chopra
Department of Microbiology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India
Search for more papers by this authorSunil Misra
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Search for more papers by this authorCorresponding Author
Haridas B. Rode
Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, Telangana, India
Academy of Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India
Correspondence Haridas B. Rode, Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, Telangana 500 007, India.
Email: [email protected]
Search for more papers by this authorAbstract
A facile strategy was developed for the synthesis of biologically important 4,5-dihydropyrrolo[1,2-a]quinoxalines and pyrrolo[1,2-a]quinoxalin]-2-ones by treating 2-(1H-pyrrol-1-yl)anilines with imidazo[1,2-a]pyridine-3-carbaldehyde or isatin, using amidosulfonic acid (NH3SO3) as a solid catalyst in water at room temperature. The protocol has been extended to electrophile ninhydrin. The catalyst could be recycled for six times without the loss of activity. The compounds were evaluated for their antituberculosis, antibacterial, and anticancer activities. It is worth noting that compounds 3d and 3e demonstrated a minimum inhibitory concentration value of 6.25 µM against Mycobacterium tuberculosis H37Rv, whereas compounds 3d, 3g, 5d, 5e, and 5i showed a remarkable inhibition of A549, DU145, HeLa, HepG2, MCF-7, and B16-F10 cell lines, respectively. Staphylococcus aureus was inhibited by compounds 5b, 5e, 5d, 5g, and 5l at 32 µg/ml.
CONFLICTS OF INTERESTS
The authors declare that there are no conflicts of interests.
Supporting Information
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| ardp202000192-sup-0001-Supplimentary_information.docx2.7 MB | Supporting information |
| ardp202000192-sup-0002-InchI_code_and_biological_activity.docx27.3 KB | Supporting information |
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