In situ Generated Iridium Nanoparticles as Hydride Donors in Photoredox-Catalyzed Hydrogen Isotope Exchange Reactions with Deuterium and Tritium Gas
Henrik Kramp
Sanofi Germany, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany
Search for more papers by this authorRemo Weck
Sanofi Germany, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany
Search for more papers by this authorDr. Martin Sandvoss
Sanofi Germany, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany
Search for more papers by this authorDr. Anna Sib
Sanofi Germany, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany
Search for more papers by this authorDr. Gabriel Mencia
Laboratoire de Physique et Chimie des Nano-objets, Institut National des Sciences Appliquées, 135 avenue de Rangueil, 31077 Toulouse Cedex 4, France
Search for more papers by this authorDr. Pier-Francesco Fazzini
Laboratoire de Physique et Chimie des Nano-objets, Institut National des Sciences Appliquées, 135 avenue de Rangueil, 31077 Toulouse Cedex 4, France
Search for more papers by this authorProf. Dr. Bruno Chaudret
Laboratoire de Physique et Chimie des Nano-objets, Institut National des Sciences Appliquées, 135 avenue de Rangueil, 31077 Toulouse Cedex 4, France
Search for more papers by this authorCorresponding Author
Dr. Volker Derdau
Sanofi Germany, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany
Search for more papers by this authorHenrik Kramp
Sanofi Germany, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany
Search for more papers by this authorRemo Weck
Sanofi Germany, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany
Search for more papers by this authorDr. Martin Sandvoss
Sanofi Germany, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany
Search for more papers by this authorDr. Anna Sib
Sanofi Germany, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany
Search for more papers by this authorDr. Gabriel Mencia
Laboratoire de Physique et Chimie des Nano-objets, Institut National des Sciences Appliquées, 135 avenue de Rangueil, 31077 Toulouse Cedex 4, France
Search for more papers by this authorDr. Pier-Francesco Fazzini
Laboratoire de Physique et Chimie des Nano-objets, Institut National des Sciences Appliquées, 135 avenue de Rangueil, 31077 Toulouse Cedex 4, France
Search for more papers by this authorProf. Dr. Bruno Chaudret
Laboratoire de Physique et Chimie des Nano-objets, Institut National des Sciences Appliquées, 135 avenue de Rangueil, 31077 Toulouse Cedex 4, France
Search for more papers by this authorCorresponding Author
Dr. Volker Derdau
Sanofi Germany, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany
Search for more papers by this authorGraphical Abstract
We demonstrate the synergistic approach of in situ generated iridium nanoparticles in photoredox-catalyzed and CH-functionalization hydrogen isotope exchange with deuterium and tritium gas.
Abstract
We have studied the photoredox-catalyzed hydrogen isotope exchange (HIE) reaction with deuterium or tritium gas as isotope sources and in situ formed transition metal nanoparticles as hydrogen atom transfer pre-catalysts. By this means we have found synergistic reactivities applying two different HIE mechanisms, namely photoredox-catalyzed and CH-functionalization HIE leading to the synthesis of highly deuterated complex molecules. Finally, we adopted these findings successfully to tritium chemistry.
Open Research
Data Availability Statement
The data that support the findings of this study are available in the supplementary material of this article.
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