Review
Activity-Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image-Guided Surgery
Dr. Haidong Li,
Dayeh Kim,
Dr. Qichao Yao,
Haoying Ge,
Jeewon Chung,
Prof. Jiangli Fan,
Prof. Jingyun Wang,
Prof. Xiaojun Peng,
Prof. Juyoung Yoon,
Dr. Haidong Li
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760 Korea
Search for more papers by this authorDayeh Kim
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760 Korea
Search for more papers by this authorDr. Qichao Yao
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian, 116024 China
Search for more papers by this authorHaoying Ge
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian, 116024 China
Search for more papers by this authorJeewon Chung
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760 Korea
Search for more papers by this authorProf. Jiangli Fan
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian, 116024 China
Ningbo Institute of Dalian University of Technology, 26 Yucai Road, Jiangbei District, Ningbo, 315016 China
Search for more papers by this authorProf. Jingyun Wang
School of Bioengineering, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian, 116024 China
Search for more papers by this authorCorresponding Author
Prof. Xiaojun Peng
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian, 116024 China
Ningbo Institute of Dalian University of Technology, 26 Yucai Road, Jiangbei District, Ningbo, 315016 China
Search for more papers by this authorCorresponding Author
Prof. Juyoung Yoon
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760 Korea
Search for more papers by this authorDr. Haidong Li,
Dayeh Kim,
Dr. Qichao Yao,
Haoying Ge,
Jeewon Chung,
Prof. Jiangli Fan,
Prof. Jingyun Wang,
Prof. Xiaojun Peng,
Prof. Juyoung Yoon,
Dr. Haidong Li
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760 Korea
Search for more papers by this authorDayeh Kim
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760 Korea
Search for more papers by this authorDr. Qichao Yao
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian, 116024 China
Search for more papers by this authorHaoying Ge
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian, 116024 China
Search for more papers by this authorJeewon Chung
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760 Korea
Search for more papers by this authorProf. Jiangli Fan
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian, 116024 China
Ningbo Institute of Dalian University of Technology, 26 Yucai Road, Jiangbei District, Ningbo, 315016 China
Search for more papers by this authorProf. Jingyun Wang
School of Bioengineering, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian, 116024 China
Search for more papers by this authorCorresponding Author
Prof. Xiaojun Peng
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian, 116024 China
Ningbo Institute of Dalian University of Technology, 26 Yucai Road, Jiangbei District, Ningbo, 315016 China
Search for more papers by this authorCorresponding Author
Prof. Juyoung Yoon
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760 Korea
Search for more papers by this authorGraphical Abstract
Near-infrared enzyme-activatable fluorescent probes have been considered to be an effective tool for the diagnosis and treatment of tumors. This review focuses on the design strategy of enzyme-activated fluorescent probes, the development of biological applications and new multifunctional probes as well as the direction of clinical transformation.
Abstract
Near-infrared (NIR) activatable fluorescent probes have been considered to be the effective edge tools for the investigation of cell biology and disease diagnosis because of their outstanding advantages. Related genes involved in tumor genesis and progression regulate the overexpression of certain enzymes. Owing to the distinctive characteristics of quick reaction time and favorable pharmacokinetics, enzyme-reactive NIR optical probes have shown great potential in the diagnosis of tumorigenesis and in image-guided intraoperative surgeries with high signal-to-noise ratios. In this review, we mainly summarize the latest advancements in enzyme-reactive NIR fluorescent probes from design strategy to biomedical application. Specifically, some challenges and prospects in this field are presented at the end of the review, which will be beneficial to innovatively construct new multifunctional fluorescent probes and actively promote their clinical transformation in the future.
Conflict of interest
The authors declare no conflict of interest.
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