Propagation of Oscillating Chemical Signals through Reaction Networks
Dr. Rafał Roszak
Institute of Organic Chemistry, Polish Academy of Sciences, Ul. Kasprzaka 44/52, Warsaw, 02-224 Poland
Search for more papers by this authorMichał D. Bajczyk
Institute of Organic Chemistry, Polish Academy of Sciences, Ul. Kasprzaka 44/52, Warsaw, 02-224 Poland
Search for more papers by this authorEwa P. Gajewska
Institute of Organic Chemistry, Polish Academy of Sciences, Ul. Kasprzaka 44/52, Warsaw, 02-224 Poland
Search for more papers by this authorCorresponding Author
Prof. Robert Hołyst
Institute of Physical Chemistry, Polish Academy of Sciences, Ul. Kasprzaka 44/52, Warsaw, 02-224 Poland
Search for more papers by this authorCorresponding Author
Prof. Bartosz A. Grzybowski
Institute of Organic Chemistry, Polish Academy of Sciences, Ul. Kasprzaka 44/52, Warsaw, 02-224 Poland
IBS Center for Soft and Living Matter and Department of Chemistry, UNIST, 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, South Korea
Search for more papers by this authorDr. Rafał Roszak
Institute of Organic Chemistry, Polish Academy of Sciences, Ul. Kasprzaka 44/52, Warsaw, 02-224 Poland
Search for more papers by this authorMichał D. Bajczyk
Institute of Organic Chemistry, Polish Academy of Sciences, Ul. Kasprzaka 44/52, Warsaw, 02-224 Poland
Search for more papers by this authorEwa P. Gajewska
Institute of Organic Chemistry, Polish Academy of Sciences, Ul. Kasprzaka 44/52, Warsaw, 02-224 Poland
Search for more papers by this authorCorresponding Author
Prof. Robert Hołyst
Institute of Physical Chemistry, Polish Academy of Sciences, Ul. Kasprzaka 44/52, Warsaw, 02-224 Poland
Search for more papers by this authorCorresponding Author
Prof. Bartosz A. Grzybowski
Institute of Organic Chemistry, Polish Academy of Sciences, Ul. Kasprzaka 44/52, Warsaw, 02-224 Poland
IBS Center for Soft and Living Matter and Department of Chemistry, UNIST, 50, UNIST-gil, Eonyang-eup, Ulju-gun, Ulsan, South Korea
Search for more papers by this authorGraphical Abstract
Reaction networks do not like high frequencies: Similar to electronic systems that can tune to and process signals of select frequencies, systems/networks of chemical reactions “propagate” oscillatory concentration inputs in a frequency-dependent manner. In particular, simulations in the Kinetix software reveal that for diverse system architectures oscillations are transmitted only up to a certain threshold value and are dampened for higher frequencies.
Abstract
Akin to electronic systems that can tune to and process signals of select frequencies, systems/networks of chemical reactions also “propagate” time-varying concentration inputs in a frequency-dependent manner. Whereas signals of low frequencies are transmitted, higher frequency inputs are dampened and converted into steady-concentration outputs. Such behavior is observed in both idealized reaction chains as well as realistic signaling cascades, in the latter case explaining the experimentally observed responses of such cascades to input calcium oscillations. These and other results are supported by numerical simulations within the freely available Kinetix web application we developed to study chemical systems of arbitrary architectures, reaction kinetics, and boundary conditions.
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