Review
Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences
Dr. Jens Atzrodt,
Dr. Volker Derdau,
Prof. Dr. William J. Kerr,
Dr. Marc Reid,
Corresponding Author
Dr. Jens Atzrodt
Isotope Chemistry and Metabolite Synthesis, Integrated Drug Discovery, Medicinal Chemistry, Industriepark Höchst, G876, 65926 Frankfurt, Germany
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Dr. Volker Derdau
Isotope Chemistry and Metabolite Synthesis, Integrated Drug Discovery, Medicinal Chemistry, Industriepark Höchst, G876, 65926 Frankfurt, Germany
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Prof. Dr. William J. Kerr
Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, G1 1XL UK
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Dr. Marc Reid
Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, G1 1XL UK
Search for more papers by this authorDr. Jens Atzrodt,
Dr. Volker Derdau,
Prof. Dr. William J. Kerr,
Dr. Marc Reid,
Corresponding Author
Dr. Jens Atzrodt
Isotope Chemistry and Metabolite Synthesis, Integrated Drug Discovery, Medicinal Chemistry, Industriepark Höchst, G876, 65926 Frankfurt, Germany
Search for more papers by this authorCorresponding Author
Dr. Volker Derdau
Isotope Chemistry and Metabolite Synthesis, Integrated Drug Discovery, Medicinal Chemistry, Industriepark Höchst, G876, 65926 Frankfurt, Germany
Search for more papers by this authorCorresponding Author
Prof. Dr. William J. Kerr
Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, G1 1XL UK
Search for more papers by this authorCorresponding Author
Dr. Marc Reid
Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, G1 1XL UK
Search for more papers by this authorGraphical Abstract
The isotopes of hydrogen are unique tools for identifying and understanding biological and chemical processes. In this Review, advances in the field of hydrogen isotope applications in various areas of the life sciences are described.
Abstract
Hydrogen isotopes are unique tools for identifying and understanding biological and chemical processes. Hydrogen isotope labelling allows for the traceless and direct incorporation of an additional mass or radioactive tag into an organic molecule with almost no changes in its chemical structure, physical properties, or biological activity. Using deuterium-labelled isotopologues to study the unique mass-spectrometric patterns generated from mixtures of biologically relevant molecules drastically simplifies analysis. Such methods are now providing unprecedented levels of insight in a wide and continuously growing range of applications in the life sciences and beyond. Tritium (3H), in particular, has seen an increase in utilization, especially in pharmaceutical drug discovery. The efforts and costs associated with the synthesis of labelled compounds are more than compensated for by the enhanced molecular sensitivity during analysis and the high reliability of the data obtained. In this Review, advances in the application of hydrogen isotopes in the life sciences are described.
Conflict of interest
The authors declare no conflict of interest.
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Citing Literature
February 12, 2018
Pages 1758-1784
