Molecular Mechanism of Prion Protein Oligomerization at Atomic Resolution†
Dr. Kai Schlepckow
Institut für Organische Chemie und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt am Main, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main (Germany) http://schwalbe.org.chemie.uni-frankfurt.de
Search for more papers by this authorCorresponding Author
Prof. Dr. Harald Schwalbe
Institut für Organische Chemie und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt am Main, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main (Germany) http://schwalbe.org.chemie.uni-frankfurt.de
Institut für Organische Chemie und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt am Main, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main (Germany) http://schwalbe.org.chemie.uni-frankfurt.de===Search for more papers by this authorDr. Kai Schlepckow
Institut für Organische Chemie und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt am Main, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main (Germany) http://schwalbe.org.chemie.uni-frankfurt.de
Search for more papers by this authorCorresponding Author
Prof. Dr. Harald Schwalbe
Institut für Organische Chemie und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt am Main, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main (Germany) http://schwalbe.org.chemie.uni-frankfurt.de
Institut für Organische Chemie und Chemische Biologie, Zentrum für Biomolekulare Magnetische Resonanz (BMRZ), Johann Wolfgang Goethe-Universität Frankfurt am Main, Max-von-Laue-Strasse 7, 60438 Frankfurt am Main (Germany) http://schwalbe.org.chemie.uni-frankfurt.de===Search for more papers by this authorFinancial support of this work through the German Research Foundation (DFG, grant number Schw701/9-1,9-2) and through the state of Hessen (BMRZ) is gratefully acknowledged. H.S. is a member of the DFG-funded Cluster of Excellence: Macromolecular Complexes. We thank Nils Walter for helpful discussions, Julia Wirmer-Bartoschek for critically reading the manuscript, and Sven Warhaut for preparation of an NMR sample.
Graphical Abstract
Prion protein oligomerization: Despite the crucial role of oligomers during prion protein (PrP) pathogenesis the molecular mechanism of their formation has remained largely elusive. A 2D time-resolved NMR study which made it possible to characterize the oligomerization kinetics with unprecedented site-specificity is reported (see picture).
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