Transition-Metal-Free Multicomponent Reactions Involving Arynes, N-Heterocycles, and Isatins†
Anup Bhunia
Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune (India) http://academic.ncl.res.in/ncl_1/at.biju
Search for more papers by this authorTony Roy
Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune (India) http://academic.ncl.res.in/ncl_1/at.biju
Search for more papers by this authorPradip Pachfule
Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Pune (India)
Search for more papers by this authorDr. Pattuparambil R. Rajamohanan
Central NMR Facility, CSIR-National Chemical Laboratory (CSIR-NCL), Pune (India)
Search for more papers by this authorCorresponding Author
Dr. Akkattu T. Biju
Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune (India) http://academic.ncl.res.in/ncl_1/at.biju
Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune (India) http://academic.ncl.res.in/ncl_1/at.biju===Search for more papers by this authorAnup Bhunia
Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune (India) http://academic.ncl.res.in/ncl_1/at.biju
Search for more papers by this authorTony Roy
Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune (India) http://academic.ncl.res.in/ncl_1/at.biju
Search for more papers by this authorPradip Pachfule
Physical/Materials Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Pune (India)
Search for more papers by this authorDr. Pattuparambil R. Rajamohanan
Central NMR Facility, CSIR-National Chemical Laboratory (CSIR-NCL), Pune (India)
Search for more papers by this authorCorresponding Author
Dr. Akkattu T. Biju
Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune (India) http://academic.ncl.res.in/ncl_1/at.biju
Organic Chemistry Division, CSIR-National Chemical Laboratory (CSIR-NCL), Dr. Homi Bhabha Road, Pune (India) http://academic.ncl.res.in/ncl_1/at.biju===Search for more papers by this authorThis work was supported by CSIR-NCL (start-up grant to A.T.B., MLP022426), CSIR-New Delhi (Network project-ORIGIN, CSC0108) and CSIR-OSDD (HCP0001). A.B. and P.P. thank CSIR-New Delhi for the award of a Research Fellowship. We thank Dr. Rahul Banerjee for support with X-ray analysis, and B. Santhakumari for the HRMS data.
Graphical Abstract
Mix and match: With isoquinoline as the nucleophilic trigger, multicomponent reactions afforded spirooxazino isoquinoline derivatives, proceeding through 1,4-dipolar intermediates. The use of pyridine as a nucleophile furnished indolin-2-one derivatives, with the reaction likely proceeding through a pyridylidene intermediate.
Supporting Information
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