Zinc-Catalyzed Synthesis of Functionalized Furans and Triarylmethanes from Enynones and Alcohols or Azoles: Dual XH Bond Activation by Zinc†
Jesús González
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)
Search for more papers by this authorDr. Javier González
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)
Search for more papers by this authorCarmela Pérez-Calleja
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)
Search for more papers by this authorCorresponding Author
Dr. Luis A. López
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)Search for more papers by this authorCorresponding Author
Dr. Rubén Vicente
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)Search for more papers by this authorJesús González
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)
Search for more papers by this authorDr. Javier González
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)
Search for more papers by this authorCarmela Pérez-Calleja
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)
Search for more papers by this authorCorresponding Author
Dr. Luis A. López
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)Search for more papers by this authorCorresponding Author
Dr. Rubén Vicente
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)
Departamento de Química Orgánica e Inorgánica e Instituto Universitario de Química Organometálica “Enrique Moles”, Universidad de Oviedo c/Julián Clavería 8, 33007 Oviedo (Spain)Search for more papers by this authorFinancial support from the Ministerio de Economía y Competitividad of Spain (Grant CTQ2012-20517-C02-01 and predoctoral grant for J.G.) is gratefully acknowledged. Calculations were carried out at the “Cluster de Modelización Científica” (Universidad de Oviedo). R.V. is a Ramón y Cajal Fellow.
Graphical Abstract
Ba'zinc'ga! A zinc-catalyzed sequence involving a cyclization with a subsequent CO, CN, or CC bond formation enables the preparation of a variety of valuable furfuryl ethers (with alcohols) and unsymmetrically substituted triarylmethane derivatives (with azoles or arenes). ZnCl2 serves as the catalyst.
Supporting Information
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