Volume 51, Issue 43 pp. 10800-10803

Communication

Self-Healing Microencapsulation of Biomacromolecules without Organic Solvents^†

Dr. Samuel E. Reinhold,

Dr. Samuel E. Reinhold

Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)

Present address: Upsher-Smith Laboratories, Inc. 6701 Evenstad Drive, Maple Grove, MN 55369 (USA)

These authors contributed equally to this research.

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Dr. Kashappa-Goud H. Desai,

Dr. Kashappa-Goud H. Desai

Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)

These authors contributed equally to this research.

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Dr. Li Zhang,

Dr. Li Zhang

Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)

Present address: Teva Parenteral Medicines, 19 Hughes, Irvine, CA 92618 (USA)

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Karl F. Olsen,

Karl F. Olsen

Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)

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Prof. Steven P. Schwendeman,

Corresponding Author

Prof. Steven P. Schwendeman

[email protected]

Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)

Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)Search for more papers by this author

Dr. Samuel E. Reinhold,

Dr. Samuel E. Reinhold

Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)

Present address: Upsher-Smith Laboratories, Inc. 6701 Evenstad Drive, Maple Grove, MN 55369 (USA)

These authors contributed equally to this research.

Search for more papers by this author

Dr. Kashappa-Goud H. Desai,

Dr. Kashappa-Goud H. Desai

Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)

These authors contributed equally to this research.

Search for more papers by this author

Dr. Li Zhang,

Dr. Li Zhang

Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)

Present address: Teva Parenteral Medicines, 19 Hughes, Irvine, CA 92618 (USA)

Search for more papers by this author

Karl F. Olsen,

Karl F. Olsen

Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)

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Prof. Steven P. Schwendeman,

Corresponding Author

Prof. Steven P. Schwendeman

[email protected]

Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)

Department of Pharmaceutical Sciences, University of Michigan, 428 Church Street, Ann Arbor, MI 48109 (USA)Search for more papers by this author

First published: 26 September 2012

https://doi.org/10.1002/anie.201206387

Citations: 81

^†

This study was funded by NIH R01 HL 68345 and R21 EB 08873. We greatly appreciate the help of Shobha Churi and Dr. Manjunatha (JSS University, Mysore, India) in the procurement of the sample of tetanus toxoid. We are grateful to Dr. Rajesh Gupta, US Food and Drug Administration, for his assistance with ELISA and for providing the sample of equine tetanus antitoxin. We also thank Dr. Heather W. Collins, University of Pennsylvania School of Medicine, for conducting radioimmunoassays.

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Graphical Abstract

Capture and seal off all exits! Biomacromolecules are routinely microcapsulated in poly(lactic-co-glycolic acid) (PLGA) in multiple complex steps that are deleterious to the biomacromolecule. In contrast, PLGA encapsulation based on self-healing (see picture) shows high efficiency without protein damage and enables the stabilization and slow release of proteins.

Supporting Information

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Volume51, Issue43

October 22, 2012

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Self-Healing Microencapsulation of Biomacromolecules without Organic Solvents^†

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Self-Healing Microencapsulation of Biomacromolecules without Organic Solvents^†