A Phenylboronate-Functionalized Polyion Complex Micelle for ATP-Triggered Release of siRNA†
Mitsuru Naito
Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/
Search for more papers by this authorDr. Takehiko Ishii
Department of Bioengineering, The University of Tokyo (Japan)
Search for more papers by this authorDr. Akira Matsumoto
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (Japan)
Search for more papers by this authorDr. Kanjiro Miyata
Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, The University of Tokyo (Japan)
Search for more papers by this authorDr. Yuji Miyahara
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (Japan)
Search for more papers by this authorCorresponding Author
Dr. Kazunori Kataoka
Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/
Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this authorMitsuru Naito
Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/
Search for more papers by this authorDr. Takehiko Ishii
Department of Bioengineering, The University of Tokyo (Japan)
Search for more papers by this authorDr. Akira Matsumoto
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (Japan)
Search for more papers by this authorDr. Kanjiro Miyata
Division of Clinical Biotechnology, Center for Disease Biology and Integrative Medicine, The University of Tokyo (Japan)
Search for more papers by this authorDr. Yuji Miyahara
Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (Japan)
Search for more papers by this authorCorresponding Author
Dr. Kazunori Kataoka
Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/
Department of Materials Engineering, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8656 (Japan) http://www.bmw.t.u-tokyo.ac.jp/Search for more papers by this authorThis research is supported by the Japan Society for the Promotion of Science (JSPS) through the “Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program).”
Graphical Abstract
PIC-ing a winner: siRNA encapsulated by a phenylboronate-functionalized polyion complex (PIC) micelle shows binding between the phenylboronate and the 3′ ribose of the siRNA (see scheme), stabilizing the complex under conditions equivalent to the extracellular environment. This complex is disrupted in response to addition of ATP, at a concentration comparable to that inside cells.
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