Intracellular pH-Responsive Mesoporous Silica Nanoparticles for the Controlled Release of Anticancer Chemotherapeutics†
Dr. Chia-Hung Lee
Center for Nanomedicine Research, National Health Research Institutes, Zhunan, Miaoli 350 (Taiwan)
These authors contributed equally to this work.
Search for more papers by this authorShih-Hsun Cheng
Division of Medical Engineering Research, National Health Research Institutes, Zhunan Miaoli 350 (Taiwan), Fax: (+886) 37-586-440
Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu 300 (Taiwan)
These authors contributed equally to this work.
Search for more papers by this authorI-Ping Huang
Division of Medical Engineering Research, National Health Research Institutes, Zhunan Miaoli 350 (Taiwan), Fax: (+886) 37-586-440
Search for more papers by this authorDr. Jeffrey S. Souris
Department of Radiology, The University of Chicago, Chicago, IL 60637 (USA)
Search for more papers by this authorProf. Chung-Shi Yang
Center for Nanomedicine Research, National Health Research Institutes, Zhunan, Miaoli 350 (Taiwan)
Search for more papers by this authorProf. Chung-Yuan Mou
Department of Chemistry, National Taiwan University, Taipei 106 (Taiwan)
Search for more papers by this authorProf. Leu-Wei Lo
Division of Medical Engineering Research, National Health Research Institutes, Zhunan Miaoli 350 (Taiwan), Fax: (+886) 37-586-440
Search for more papers by this authorDr. Chia-Hung Lee
Center for Nanomedicine Research, National Health Research Institutes, Zhunan, Miaoli 350 (Taiwan)
These authors contributed equally to this work.
Search for more papers by this authorShih-Hsun Cheng
Division of Medical Engineering Research, National Health Research Institutes, Zhunan Miaoli 350 (Taiwan), Fax: (+886) 37-586-440
Institute of NanoEngineering and MicroSystems, National Tsing Hua University, Hsinchu 300 (Taiwan)
These authors contributed equally to this work.
Search for more papers by this authorI-Ping Huang
Division of Medical Engineering Research, National Health Research Institutes, Zhunan Miaoli 350 (Taiwan), Fax: (+886) 37-586-440
Search for more papers by this authorDr. Jeffrey S. Souris
Department of Radiology, The University of Chicago, Chicago, IL 60637 (USA)
Search for more papers by this authorProf. Chung-Shi Yang
Center for Nanomedicine Research, National Health Research Institutes, Zhunan, Miaoli 350 (Taiwan)
Search for more papers by this authorProf. Chung-Yuan Mou
Department of Chemistry, National Taiwan University, Taipei 106 (Taiwan)
Search for more papers by this authorProf. Leu-Wei Lo
Division of Medical Engineering Research, National Health Research Institutes, Zhunan Miaoli 350 (Taiwan), Fax: (+886) 37-586-440
Search for more papers by this authorThis study was supported by the Grants MED-098-PP-04 and NM-098-PP-01 from the National Health Research Institutes of Taiwan; and NSC 098-2221-E-400-001 from the National Science Council of Taiwan. We thank Yu-Ching Chen, Chia-Hui Chu, and Dr. Ching-Mao Huang for their assistance with TEM and EDX measurements.
Graphical Abstract
Cut here to cure: Doxorubicin attached to pH-sensitive mesoporous silica nanoparticles (MSN-hydrazone-Dox) shows potential in the chemotherapeutic treatment of liver cancer. Hydrolysis of the pH-sensitive hydrazone bond in the acidic environment of endosomes/lysosomes (see picture) releases Dox intracellularly from the MSN nanochannels, resulting in highly efficient apoptotic cell death.
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