A Versatile Catalyst for the Sonogashira Coupling of Aryl Chlorides†
Axel Köllhofer Dipl.-Chem.
Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, Petersenstrasse 18, 64287 Darmstadt, Germany, Fax: (+49) 6151-16-6040
Search for more papers by this authorThomas Pullmann
Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, Petersenstrasse 18, 64287 Darmstadt, Germany, Fax: (+49) 6151-16-6040
Search for more papers by this authorHerbert Plenio Prof. Dr.
Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, Petersenstrasse 18, 64287 Darmstadt, Germany, Fax: (+49) 6151-16-6040
Search for more papers by this authorAxel Köllhofer Dipl.-Chem.
Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, Petersenstrasse 18, 64287 Darmstadt, Germany, Fax: (+49) 6151-16-6040
Search for more papers by this authorThomas Pullmann
Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, Petersenstrasse 18, 64287 Darmstadt, Germany, Fax: (+49) 6151-16-6040
Search for more papers by this authorHerbert Plenio Prof. Dr.
Institut für Anorganische und Physikalische Chemie, Technische Universität Darmstadt, Petersenstrasse 18, 64287 Darmstadt, Germany, Fax: (+49) 6151-16-6040
Search for more papers by this authorThis work was supported by the Deutsche Forschungsgemeinschaft and the TU Darmstadt.
Graphical Abstract
Aryl chlorides are suitable substrates for the Sonogashira coupling! By using the versatile catalyst system Na2[PdCl4]/PR3/CuI (PR3=(1-Ad)2PBn, PtBu3), the Sonogashira coupling [Eq. (a)] of aryl chlorides with alkynes generates excellent yields of the corresponding disubstituted aryl alkynes.
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