Scientific Perspective
A Forward Vision for Chemodynamic Therapy: Issues and Opportunities
Dr. Peiran Zhao,
Dr. Huiyan Li,
Prof. Wenbo Bu,
Dr. Peiran Zhao
Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433 P.R. China
Search for more papers by this authorCorresponding Author
Dr. Huiyan Li
Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433 P.R. China
Search for more papers by this authorCorresponding Author
Prof. Wenbo Bu
Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433 P.R. China
Search for more papers by this authorDr. Peiran Zhao,
Dr. Huiyan Li,
Prof. Wenbo Bu,
Dr. Peiran Zhao
Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433 P.R. China
Search for more papers by this authorCorresponding Author
Dr. Huiyan Li
Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433 P.R. China
Search for more papers by this authorCorresponding Author
Prof. Wenbo Bu
Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, 200433 P.R. China
Search for more papers by this authorAbstract
Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great signs of progress have been made in the field of chemodynamic therapy (CDT). However, the exact mechanism of CDT is obscured by the unique tumor chemical environment and inevitable nanoparticle-cell interactions, thus impeding further development. In this Scientific Perspective, the significance of CDT is clarified, the complex mechanism is deconstructed into primitive chemical and biological interactions, and the mechanism research directions based on the chemical kinetics and biological signaling pathways are discussed in detail. Moreover, beneficial outlooks are presented to enlighten the evolution of next-generation CDT. Hopefully, this Scientific Perspective can inspire new ideas and advances for CDT and provide a reference for breaking down the interdisciplinary barriers in the field of nanomedicine.
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
Data sharing is not applicable to this article as no new data were created or analyzed in this study.
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