Endogenous mRNA Triggered DNA-Au Nanomachine for In Situ Imaging and Targeted Multimodal Synergistic Cancer Therapy
Sha Yu
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorDr. Yang Zhou
School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164 USA
These authors contributed equally to this work.
Search for more papers by this authorYao Sun
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China
Search for more papers by this authorShaojun Wu
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China
Search for more papers by this authorTingting Xu
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China
Search for more papers by this authorDr. Yu-Chung Chang
School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164 USA
Search for more papers by this authorCorresponding Author
Prof. Sai Bi
College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Li-Ping Jiang
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Jun-Jie Zhu
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China
Search for more papers by this authorSha Yu
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China
These authors contributed equally to this work.
Search for more papers by this authorDr. Yang Zhou
School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164 USA
These authors contributed equally to this work.
Search for more papers by this authorYao Sun
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China
Search for more papers by this authorShaojun Wu
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China
Search for more papers by this authorTingting Xu
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China
Search for more papers by this authorDr. Yu-Chung Chang
School of Mechanical and Materials Engineering, Washington State University, Pullman, WA, 99164 USA
Search for more papers by this authorCorresponding Author
Prof. Sai Bi
College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, 266071 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Li-Ping Jiang
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China
Search for more papers by this authorCorresponding Author
Prof. Jun-Jie Zhu
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023 P. R. China
Search for more papers by this authorAbstract
The development of versatile nanotheranostic platforms that integrate both diagnostic and therapeutic functions have always been an intractable challenge in precise cancer treatment. Herein, an aptamer-tethered deoxyribonucleic acids-gold particle (Apt-DNA-Au) nanomachine has been developed for in situ imaging and targeted multimodal synergistic therapy of mammary carcinoma. Upon specifically internalized into MCF-7 cells, the tumor-related TK1 mRNA activates the Apt-DNA-Au nanomachine by DNA strand displacement cascades, resulting in the release of the fluorophore and antisense DNA as well as the aggregation of AuNPs for in situ imaging, suppression of survivin expression and photothermal therapy, respectively. Meanwhile, the controlled released drugs are used for chemotherapy, while under the laser irradiation the loaded photosensitizer produces reactive oxygen species (ROS) for photodynamic therapy. The results confirm that the proposed Apt-DNA-Au nanomachine provides a powerful nanotheranostic platform for in situ imaging-guided combinatorial anticancer therapy.
Conflict of interest
The authors declare no conflict of interest.
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