A Novel Approach to Functionalization of Aryl Azides through the Generation and Reaction of Organolithium Species Bearing Masked Azides in Flow Microreactors
Daisuke Ichinari
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan
Search for more papers by this authorDr. Yosuke Ashikari
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan
Search for more papers by this authorDr. Kyoko Mandai
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan
Search for more papers by this authorYoko Aizawa
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan
Search for more papers by this authorCorresponding Author
Prof. Dr. Jun-ichi Yoshida
National Institute of Technology, Suzuka College, Shiroko-cho, Suzuka, Mie, 510-0294 Japan
deceased
Search for more papers by this authorCorresponding Author
Prof. Dr. Aiichiro Nagaki
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan
Search for more papers by this authorDaisuke Ichinari
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan
Search for more papers by this authorDr. Yosuke Ashikari
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan
Search for more papers by this authorDr. Kyoko Mandai
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan
Search for more papers by this authorYoko Aizawa
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan
Search for more papers by this authorCorresponding Author
Prof. Dr. Jun-ichi Yoshida
National Institute of Technology, Suzuka College, Shiroko-cho, Suzuka, Mie, 510-0294 Japan
deceased
Search for more papers by this authorCorresponding Author
Prof. Dr. Aiichiro Nagaki
Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan
Search for more papers by this authorAbstract
A novel straightforward method for aryl azides having functional groups based on generation and reactions of aryllithiums bearing a triazene group from polybromoarenes using flow microreactor systems was achieved. The present approach will serve as a powerful method in organolithium chemistry and open a new possibility in the synthesis of polyfunctional organic azides.
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