A Dual Killing Strategy: Photocatalytic Generation of Singlet Oxygen with Concomitant PtIV Prodrug Activation
Dr. Daniel J. Norman
EaStChem School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, UK
Search for more papers by this authorAlessia Gambardella
EaStChem School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, UK
Search for more papers by this authorProf. Andrew R. Mount
EaStChem School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, UK
Search for more papers by this authorProf. Alan F. Murray
School of Engineering, University of Edinburgh, Mayfield Rd, Edinburgh, UK
Search for more papers by this authorCorresponding Author
Prof. Mark Bradley
EaStChem School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, UK
Search for more papers by this authorDr. Daniel J. Norman
EaStChem School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, UK
Search for more papers by this authorAlessia Gambardella
EaStChem School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, UK
Search for more papers by this authorProf. Andrew R. Mount
EaStChem School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, UK
Search for more papers by this authorProf. Alan F. Murray
School of Engineering, University of Edinburgh, Mayfield Rd, Edinburgh, UK
Search for more papers by this authorCorresponding Author
Prof. Mark Bradley
EaStChem School of Chemistry, University of Edinburgh, David Brewster Road, Edinburgh, UK
Search for more papers by this authorAbstract
A ruthenium-based mitochondrial-targeting photosensitiser that undergoes efficient cell uptake, enables the rapid catalytic conversion of PtIV prodrugs into their active PtII counterparts, and drives the generation of singlet oxygen was designed. This dual mode of action drives two orthogonal cancer-cell killing mechanisms with temporal and spatial control. The designed photosensitiser was shown to elicit cell death of a panel of cancer cell lines including those showing oxaliplatin-resistance.
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