Efficient Gene Transfection through Inhibition of β-Sheet (Amyloid Fiber) Formation of a Short Amphiphilic Peptide by Gold Nanoparticles
Dr. Poulami Jana
Institute for Organic Chemistry, University of Duisburg-Essen, 45117 Essen, Germany
Search for more papers by this authorDr. Krishnananda Samanta
Institute for Organic Chemistry, University of Duisburg-Essen, 45117 Essen, Germany
Search for more papers by this authorSandra Bäcker
Institute for Biology, University of Duisburg-Essen, 45117 Essen, Germany
Search for more papers by this authorElio Zellermann
Institute for Organic Chemistry, University of Duisburg-Essen, 45117 Essen, Germany
Search for more papers by this authorProf. Shirley Knauer
Institute for Biology, University of Duisburg-Essen, 45117 Essen, Germany
Search for more papers by this authorCorresponding Author
Prof. Dr. Carsten Schmuck
Institute for Organic Chemistry, University of Duisburg-Essen, 45117 Essen, Germany
Search for more papers by this authorDr. Poulami Jana
Institute for Organic Chemistry, University of Duisburg-Essen, 45117 Essen, Germany
Search for more papers by this authorDr. Krishnananda Samanta
Institute for Organic Chemistry, University of Duisburg-Essen, 45117 Essen, Germany
Search for more papers by this authorSandra Bäcker
Institute for Biology, University of Duisburg-Essen, 45117 Essen, Germany
Search for more papers by this authorElio Zellermann
Institute for Organic Chemistry, University of Duisburg-Essen, 45117 Essen, Germany
Search for more papers by this authorProf. Shirley Knauer
Institute for Biology, University of Duisburg-Essen, 45117 Essen, Germany
Search for more papers by this authorCorresponding Author
Prof. Dr. Carsten Schmuck
Institute for Organic Chemistry, University of Duisburg-Essen, 45117 Essen, Germany
Search for more papers by this authorAbstract
The effect of citrate-stabilized gold nanoparticles (AuNPs) on the secondary structure of an artificial β-sheet-forming cationic peptide has been studied. The AuNPs inhibited β-sheet formation and led to fragmented fibrils and spherical oligomers with assembled AuNPs on their surface. Besides this structural change, the functional properties of the peptide are also different. Whereas the peptide was unable to act as a vector for gene delivery, formation of a complex with AuNPs allowed successful gene delivery into cells.
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