Nickel-Catalyzed Decarboxylative Difluoroalkylation of α,β-Unsaturated Carboxylic Acids
Gang Li
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Search for more papers by this authorTao Wang
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Search for more papers by this authorFan Fei
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Search for more papers by this authorDr. Yi-Ming Su
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Search for more papers by this authorDr. Yan Li
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Search for more papers by this authorDr. Quan Lan
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Xi-Sheng Wang
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Shanghai, 200032 China
Search for more papers by this authorGang Li
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Search for more papers by this authorTao Wang
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Search for more papers by this authorFan Fei
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Search for more papers by this authorDr. Yi-Ming Su
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Search for more papers by this authorDr. Yan Li
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Search for more papers by this authorDr. Quan Lan
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Xi-Sheng Wang
Department of Chemistry, University of Science and Technology of China, Hefei, 230026 China
Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Chinese Academy of Sciences, Shanghai Institute of Organic Chemistry, Shanghai, 200032 China
Search for more papers by this authorAbstract
The first example of nickel-catalyzed decarboxylative fluoroalkylation of α,β-unsaturated carboxylic acids has been developed with commonly available fluoroalkyl halides. This novel transformation has demonstrated broad substrate scope, excellent functional-group tolerance, mild reaction conditions, and excellent stereoselectivity. Mechanistic investigations indicate that a fluoroalkyl radical is involved in the catalytic cycle.
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