Aufsatz
Stimuliresponsive DNA-funktionalisierte Nano- und Mikrocontainer zur schaltbaren und kontrollierten Freisetzung
Dr. Chun-Hua Lu,
Prof. Itamar Willner,
Dr. Chun-Hua Lu
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel) http://chem.ch.huji.ac.il/willner/
Search for more papers by this authorCorresponding Author
Prof. Itamar Willner
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel) http://chem.ch.huji.ac.il/willner/
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel) http://chem.ch.huji.ac.il/willner/Search for more papers by this authorDr. Chun-Hua Lu,
Prof. Itamar Willner,
Dr. Chun-Hua Lu
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel) http://chem.ch.huji.ac.il/willner/
Search for more papers by this authorCorresponding Author
Prof. Itamar Willner
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel) http://chem.ch.huji.ac.il/willner/
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel) http://chem.ch.huji.ac.il/willner/Search for more papers by this authorAbstract
Stimuliresponsive DNA-funktionalisierte Nano- und Mikrocontainer, die aus mesoporösen SiO2-Nanopartikeln (SiO2-NPs), Mikrokapseln oder Micellen/Vesikeln bestehen, fungieren als Träger zur Freisetzung von Wirkstoffen. Die in den DNA-Sequenzen gespeicherte Information liefert den Code für die Ver- und Entriegelung der wirkstoffbeladenen Poren mesoporöser SiO2-NPs, für den Auf- und Abbau von Mikrokapseln oder Lipid-DNA-Micellen bzw. Lipid-DNA-Vesikeln und für den gezielten Transport von Nano- und Mikrocontainern zu Krebszellen. Es werden verschiedene Trigger eingesetzt, um die in den Nano- und Mikrocontainern enthaltenen Wirkstoffe durch Entriegelung der Poren der mesoporösen SiO2-NPs oder durch Abbau der Container freizusetzen. Hierzu gehören schaltbare DNA-Nanostrukturen (Nukleinsäure-Haarnadeln, i-Motive, G-Quadruplexe) und die Anwendung chemischer, thermischer oder photonischer Stimuli. Außerdem werden durch DNAzyme oder Enzyme stimulierte katalytische Prozesse genutzt, um die Wirkstoffe aus den Nano- und Mikrocontainern freizusetzen.
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