Aqueous Anion Receptors through Reduction of Subcomponent Self-Assembled Structures†
Jesús Mosquera
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK) http://www-jrn.ch.cam.ac.uk
Search for more papers by this authorDr. Salvatore Zarra
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK) http://www-jrn.ch.cam.ac.uk
Search for more papers by this authorCorresponding Author
Dr. Jonathan R. Nitschke
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK) http://www-jrn.ch.cam.ac.uk
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK) http://www-jrn.ch.cam.ac.ukSearch for more papers by this authorJesús Mosquera
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK) http://www-jrn.ch.cam.ac.uk
Search for more papers by this authorDr. Salvatore Zarra
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK) http://www-jrn.ch.cam.ac.uk
Search for more papers by this authorCorresponding Author
Dr. Jonathan R. Nitschke
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK) http://www-jrn.ch.cam.ac.uk
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW (UK) http://www-jrn.ch.cam.ac.ukSearch for more papers by this authorThis work was supported by the UK Engineering and Physical Sciences Research Council (EPSRC). J.M. thanks the Spanish MICINN for funding his PhD fellowship. The authors thank the EPSRC Mass Spectrometry Service at Swansea for conducting ESI-MS analysis and C. S. Wood for providing 4,4′-diformyl-3,3′-bipyridine employed in the initial experiments of the project.
Abstract
To prepare new functional covalent architectures that are difficult to synthesize using conventional organic methods, we developed a strategy that employs metal–organic assemblies as precursors, which are then reduced and demetalated. The host–guest chemistry of the larger receptor thus prepared was studied using NMR spectroscopy and fluorescence experiments. This host was observed to strongly bind aromatic polyanions in water, including the fluorescent dye molecule pyranine with nanomolar affinity, thus allowing for the design of an indicator-displacement assay.
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