A Controlled-Release Nanocarrier with Extracellular pH Value Driven Tumor Targeting and Translocation for Drug Delivery†
Dr. Zilong Zhao
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorHongmin Meng
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorNannan Wang
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorMichael J. Donovan
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorTing Fu
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorDr. Mingxu You
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorProf. Zhuo Chen
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorCorresponding Author
Prof. Xiaobing Zhang
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)Search for more papers by this authorCorresponding Author
Prof. Weihong Tan
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)Search for more papers by this authorDr. Zilong Zhao
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorHongmin Meng
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorNannan Wang
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorMichael J. Donovan
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorTing Fu
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorDr. Mingxu You
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorProf. Zhuo Chen
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Search for more papers by this authorCorresponding Author
Prof. Xiaobing Zhang
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)Search for more papers by this authorCorresponding Author
Prof. Weihong Tan
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology and College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and, Molecular Medicine Hunan University, Changsha, 410082 (China)Search for more papers by this authorThis work is supported by the National Key Scientific Program of China (2011CB911000), the Foundation for Innovative Research Groups of NSFC (Grant 21221003), and China National Instrumentation Program 2011YQ03012412.
Graphical Abstract
pHLIP statt Flop: Die Funktionalisierung mesoporöser Kieselgelnanopartikel (MSNs) mit pHLIPss-Peptid ergab ein Transportsystem mit gezielter Wirkstoff-Freisetzung in der sauren Mikroumgebung von Tumoren. Bei niedrigen pH-Werten schiebt sich pHLIPss in die Zellmembran ein und sorgt für die Aufnahme der Träger durch die Zelle; dort wird dann der Partikelinhalt durch Spaltung von pHLIPss-Disulfidbrücken freigesetzt (siehe Schema).
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