Palladium-Catalyzed Intramolecular ipso-Friedel–Crafts Alkylation of Phenols and Indoles: Rearomatization-Assisted Oxidative Addition†
Dr. Tetsuhiro Nemoto
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)
Search for more papers by this authorZengduo Zhao
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)
Search for more papers by this authorTakuya Yokosaka
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)
Search for more papers by this authorYuta Suzuki
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)
Search for more papers by this authorRiliga Wu
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)
Search for more papers by this authorCorresponding Author
Prof. Dr. Yasumasa Hamada
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)===Search for more papers by this authorDr. Tetsuhiro Nemoto
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)
Search for more papers by this authorZengduo Zhao
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)
Search for more papers by this authorTakuya Yokosaka
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)
Search for more papers by this authorYuta Suzuki
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)
Search for more papers by this authorRiliga Wu
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)
Search for more papers by this authorCorresponding Author
Prof. Dr. Yasumasa Hamada
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)
Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675 (Japan)===Search for more papers by this authorThis work was supported by Grant-in Aid for Scientific Resarch from the JSPS (Japan), the Research Foundation for Pharmaceutical Sciences, Chiba Univsersity, and the Inohana Foundation (Chiba University).
Graphical Abstract
Inspiroierend: Eine neuartige Synthese von Spirocyclen basierend auf einer Palladium-katalysierten intramolekularen ipso-Friedel-Crafts-Alkylierung von Phenolen (siehe Schema; dba=Dibenzylidenaceton) und Indolen wird beschrieben. Mechanistische Studien belegen, dass die Reaktion über eine präzedenzlose Rearomatisierungs-unterstützte oxidative Addition verläuft.
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