Zuschrift
Catalytic Asymmetric Intramolecular Hydroacylation with Rhodium/Phosphoramidite–Alkene Ligand Complexes†
Dr. Thomas J. Hoffman,
Prof. Dr. Erick M. Carreira,
Dr. Thomas J. Hoffman
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland) http://www.carreira.ethz.ch
Search for more papers by this authorCorresponding Author
Prof. Dr. Erick M. Carreira
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland) http://www.carreira.ethz.ch
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland) http://www.carreira.ethz.chSearch for more papers by this authorDr. Thomas J. Hoffman,
Prof. Dr. Erick M. Carreira,
Dr. Thomas J. Hoffman
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland) http://www.carreira.ethz.ch
Search for more papers by this authorCorresponding Author
Prof. Dr. Erick M. Carreira
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland) http://www.carreira.ethz.ch
Laboratorium für Organische Chemie, ETH Zürich, 8093 Zürich (Switzerland) http://www.carreira.ethz.chSearch for more papers by this author†
We thank Dr. Marc LaFrance for his assistance in ligand synthesis.
Graphical Abstract
Zur Synthese funktionalisierter Cyclopentanone in guten Ausbeuten und mit hohen Enantioselektivitäten wurde eine asymmetrische intramolekulare Rh-katalysierte Hydroacylierung von Pent-4-enalen entwickelt (siehe Schema; DCE=1,2-Dichlorethan). Dieser Prozess nutzt Rh-Komplexe mit neuartigen modularen Phosphoramidit-Alken-Liganden und achiralen Phosphin-Coliganden.
Supporting Information
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