Regioselective Synthesis of Indenols by Rhodium-Catalyzed CH Activation and Carbocyclization of Aryl Ketones and Alkynes†
Krishnamoorthy Muralirajan
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan (China), Fax: (+886) 3572-4698 http://mx.nthu.edu.tw/%7Echcheng
Search for more papers by this authorDr. Kanniyappan Parthasarathy
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan (China), Fax: (+886) 3572-4698 http://mx.nthu.edu.tw/%7Echcheng
Search for more papers by this authorCorresponding Author
Prof. Dr. Chien-Hong Cheng
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan (China), Fax: (+886) 3572-4698 http://mx.nthu.edu.tw/%7Echcheng
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan (China), Fax: (+886) 3572-4698 http://mx.nthu.edu.tw/%7EchchengSearch for more papers by this authorKrishnamoorthy Muralirajan
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan (China), Fax: (+886) 3572-4698 http://mx.nthu.edu.tw/%7Echcheng
Search for more papers by this authorDr. Kanniyappan Parthasarathy
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan (China), Fax: (+886) 3572-4698 http://mx.nthu.edu.tw/%7Echcheng
Search for more papers by this authorCorresponding Author
Prof. Dr. Chien-Hong Cheng
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan (China), Fax: (+886) 3572-4698 http://mx.nthu.edu.tw/%7Echcheng
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan (China), Fax: (+886) 3572-4698 http://mx.nthu.edu.tw/%7EchchengSearch for more papers by this authorWe thank the National Science Council of China (NSC-99-2811M-007-089) for support of this research.
Graphical Abstract
Keton und Alkin kommen zusammen: Die Titelreaktion verläuft bei 120 °C rasch und ist bereits nach einer Stunde abgeschlossen (siehe Schema). Die einzelnen Schritte sind vermutlich eine chelatgestützte ortho-C-H-Aktivierung, die Insertion der Alkineinheit, eine Carbocyclisierung und eine Protonierung. Cp*=Pentamethylcyclopentadienyl.
Supporting Information
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