Assessment of Tumor Metastasis by the Direct Determination of Cell-Membrane Sialic Acid Expression†
Akira Matsumoto Dr.
Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506
Search for more papers by this authorHoracio Cabral Dr.
Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506
Search for more papers by this authorNaoko Sato
Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506
Search for more papers by this authorKazunori Kataoka Dr.
Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506
Search for more papers by this authorYuji Miyahara Dr.
Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506
Biomaterials Center and International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Namiki 1-1, Tsukuba, Ibaraki 305-0044 (Japan)
Search for more papers by this authorAkira Matsumoto Dr.
Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506
Search for more papers by this authorHoracio Cabral Dr.
Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506
Search for more papers by this authorNaoko Sato
Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506
Search for more papers by this authorKazunori Kataoka Dr.
Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506
Search for more papers by this authorYuji Miyahara Dr.
Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506
Biomaterials Center and International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Namiki 1-1, Tsukuba, Ibaraki 305-0044 (Japan)
Search for more papers by this authorThis research was supported in part by the JST, CREST.
Graphical Abstract
Eine selbstorganisierte Monoschicht von Phenylboronsäure auf der Oberfläche einer Goldelektrode ermöglicht die potentiometrische Detektion von Sialinsäure (SA) an Zellmembranen (siehe Diagramm) und die Unterscheidung gesunder Pneumozyten von metastasierenden Melanomzellen anhand der veränderten SA-Expression. Dieser Ansatz zur Diagnose der Malignität oder des Ausmaßes der Metastasenbildung ist vielversprechend für eine markerfreie, nichtinvasive Zytologie in Echtzeit.
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