Volume 122, Issue 32 pp. 5626-5629
Zuschrift

Assessment of Tumor Metastasis by the Direct Determination of Cell-Membrane Sialic Acid Expression

Akira Matsumoto Dr.

Akira Matsumoto Dr.

Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506

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Horacio Cabral Dr.

Horacio Cabral Dr.

Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506

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Naoko Sato

Naoko Sato

Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506

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Kazunori Kataoka Dr.

Kazunori Kataoka Dr.

Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506

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Yuji Miyahara Dr.

Yuji Miyahara Dr.

Centre for NanoBio Integration, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo (Japan), Fax: (+81) 29-860-4506

Biomaterials Center and International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Namiki 1-1, Tsukuba, Ibaraki 305-0044 (Japan)

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First published: 22 July 2010
Citations: 20

This research was supported in part by the JST, CREST.

Graphical Abstract

Eine selbstorganisierte Monoschicht von Phenylboronsäure auf der Oberfläche einer Goldelektrode ermöglicht die potentiometrische Detektion von Sialinsäure (SA) an Zellmembranen (siehe Diagramm) und die Unterscheidung gesunder Pneumozyten von metastasierenden Melanomzellen anhand der veränderten SA-Expression. Dieser Ansatz zur Diagnose der Malignität oder des Ausmaßes der Metastasenbildung ist vielversprechend für eine markerfreie, nichtinvasive Zytologie in Echtzeit.

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