Annals of Neurology: Volume 78, Number 2, August 2015

ON THE COVER: In vivo multiphoton microscopy image of dendrites within the somatosensory cortex of a familial hemiplegic migraine mutant mouse expressing the genetically encoded Ca²⁺-indicator yellow cameleon YC3.6. Epidural application of KCl onto the occipital cortex triggered a cortical spreading depression wave that was associated with dendritic beading and a rapid surge in neuronal [Ca²⁺]_i as indicated by change in pseudocolor (from basal nanoM levels marked in blue to microM levels marked in red; see also Video 7). Elevated neuronal [Ca²⁺]_i and synaptic structural changes were apparent in migraine mutant mice and can explain cortical hyperexcitability. Field dimension: 126 μm × 126 μm. For more information, see the article by Eikermann-Haerter et al. (pages 193–210).