Volume 64, Issue 3 pp. 344-347

Original Article

Calcification and endothelialization of thrombi in acute stroke

Mohammed A. Almekhlafi MD,

Mohammed A. Almekhlafi MD

Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

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William Y. Hu MD,

William Y. Hu MD

Department of Diagnostic Imaging, University of Calgary, Calgary, Alberta, Canada

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Michael D. Hill MD,

Michael D. Hill MD

Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

Department of Medicine, University of Calgary, Calgary, Alberta, Canada

Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada

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Roland N. Auer MD PhD,

Corresponding Author

Roland N. Auer MD PhD

[email protected]

Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada

Department of Pathology and Laboratory Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, CanadaSearch for more papers by this author

Mohammed A. Almekhlafi MD,

Mohammed A. Almekhlafi MD

Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

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William Y. Hu MD,

William Y. Hu MD

Department of Diagnostic Imaging, University of Calgary, Calgary, Alberta, Canada

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Michael D. Hill MD,

Michael D. Hill MD

Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada

Department of Medicine, University of Calgary, Calgary, Alberta, Canada

Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada

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Roland N. Auer MD PhD,

Corresponding Author

Roland N. Auer MD PhD

[email protected]

Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada

Department of Pathology and Laboratory Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, CanadaSearch for more papers by this author

First published: 20 June 2008

https://doi.org/10.1002/ana.21404

Citations: 73

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Abstract

We report chronic histopathological features in thrombi mechanically retrieved from five acute ischemic stroke patients with a median age of 68 years and a median pretreatment National Institutes of Health Stroke Scale score of 13. Early endothelialization occurred over and within the thrombus, and calcifications were seen, in addition to the usual acute laminar fibrin, intervening red blood cells, and neutrophils. The effectiveness of tissue plasminogen activator in clot dissolution might be affected by these features, if extensive. Thrombus composition could critically determine the success of chemical thrombolysis. Our results should stimulate the development of imaging modalities to determine thrombus composition. Ann Neurol 2008

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Volume64, Issue3

28 September 2008

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Calcification and endothelialization of thrombi in acute stroke

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