Brief Communications

Cardiac energetics correlates to myocardial hypertrophy in Friedreich's ataxia

Corresponding Author

Michael Bunse PhD

[email protected]

Hypertension and Diabetes Research Unit, Max Grundig Clinic, Bühl

Physikalisches Institut der Universität Tübingen, Tübingen

Hypertension and Diabetes Research Unit, Max Grundig Clinic, Schwarzwaldhochstrasse 1, 77815 Bühl, GermanySearch for more papers by this author

Nana Bit-Avragim MD,

Nana Bit-Avragim MD

The Charité, Department of Cardiology, Campus Buch and Campus Virchow clinics, Humboldt University the Max Delbrück Centre for Molecular Medicine, Berlin

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Axel Riefflin MD,

Axel Riefflin MD

The KfH, Dialysezentrum, Frankfurt on the Oder

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Andreas Perrot MS,

Andreas Perrot MS

The Charité, Department of Cardiology, Campus Buch and Campus Virchow clinics, Humboldt University the Max Delbrück Centre for Molecular Medicine, Berlin

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Oliver Schmidt PhD,

Oliver Schmidt PhD

Hypertension and Diabetes Research Unit, Max Grundig Clinic, Bühl

Physikalisches Institut der Universität Tübingen, Tübingen

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Friedmar R. Kreuz MD,

Friedmar R. Kreuz MD

Institute of Clinical Genetics, Medical Faculty Carl Gustav Carus, Technical University, Dresden, Germany

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Rainer Dietz MD,

Rainer Dietz MD

The Charité, Department of Cardiology, Campus Buch and Campus Virchow clinics, Humboldt University the Max Delbrück Centre for Molecular Medicine, Berlin

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Wulf-Ingo Jung PhD,

Wulf-Ingo Jung PhD

Hypertension and Diabetes Research Unit, Max Grundig Clinic, Bühl

Physikalisches Institut der Universität Tübingen, Tübingen

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Karl Josef Osterziel MD,

Karl Josef Osterziel MD

The Charité, Department of Cardiology, Campus Buch and Campus Virchow clinics, Humboldt University the Max Delbrück Centre for Molecular Medicine, Berlin

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Michael Bunse PhD,

Corresponding Author

Michael Bunse PhD

[email protected]

Hypertension and Diabetes Research Unit, Max Grundig Clinic, Bühl

Physikalisches Institut der Universität Tübingen, Tübingen

Hypertension and Diabetes Research Unit, Max Grundig Clinic, Schwarzwaldhochstrasse 1, 77815 Bühl, GermanySearch for more papers by this author

Nana Bit-Avragim MD,

Nana Bit-Avragim MD

The Charité, Department of Cardiology, Campus Buch and Campus Virchow clinics, Humboldt University the Max Delbrück Centre for Molecular Medicine, Berlin

Search for more papers by this author

Axel Riefflin MD,

Axel Riefflin MD

The KfH, Dialysezentrum, Frankfurt on the Oder

Search for more papers by this author

Andreas Perrot MS,

Andreas Perrot MS

The Charité, Department of Cardiology, Campus Buch and Campus Virchow clinics, Humboldt University the Max Delbrück Centre for Molecular Medicine, Berlin

Search for more papers by this author

Oliver Schmidt PhD,

Oliver Schmidt PhD

Hypertension and Diabetes Research Unit, Max Grundig Clinic, Bühl

Physikalisches Institut der Universität Tübingen, Tübingen

Search for more papers by this author

Friedmar R. Kreuz MD,

Friedmar R. Kreuz MD

Institute of Clinical Genetics, Medical Faculty Carl Gustav Carus, Technical University, Dresden, Germany

Search for more papers by this author

Rainer Dietz MD,

Rainer Dietz MD

The Charité, Department of Cardiology, Campus Buch and Campus Virchow clinics, Humboldt University the Max Delbrück Centre for Molecular Medicine, Berlin

Search for more papers by this author

Wulf-Ingo Jung PhD,

Wulf-Ingo Jung PhD

Hypertension and Diabetes Research Unit, Max Grundig Clinic, Bühl

Physikalisches Institut der Universität Tübingen, Tübingen

Search for more papers by this author

Karl Josef Osterziel MD,

Karl Josef Osterziel MD

The Charité, Department of Cardiology, Campus Buch and Campus Virchow clinics, Humboldt University the Max Delbrück Centre for Molecular Medicine, Berlin

Search for more papers by this author

First published: 04 December 2002

https://doi.org/10.1002/ana.10419

Citations: 37

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Abstract

Friedreich's ataxia is a neurodegenerative disease frequently associated with hypertrophic cardiomyopathy. We have determined mitochondrial ATP, phosphocreatine, and intracellular inorganic phosphate levels by ³¹P nuclear magnetic resonance spectroscopy in the heart of 11 Friedreich's ataxia patients and 11 healthy controls. For the first time, to our knowledge, we showed a significant correlation between the extent of myocardial energy deficiency and the degree of myocardial hypertrophy. When combining our results with previous works on Friedreich's ataxia, these novel findings suggest that energy metabolism is most likely the cause and hypertrophy the effect in Friedreich's ataxia. Ann Neurol 2003;53:000–000

References

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Volume53, Issue1

January 2003

Pages 121-123

Cardiac energetics correlates to myocardial hypertrophy in Friedreich's ataxia

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Cardiac energetics correlates to myocardial hypertrophy in Friedreich's ataxia

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