Chapter 16
Quantitative Drug Metabolism with Accelerator Mass Spectrometry
Book Editor(s):Mike S. Lee, Mingshe Zhu,
Mingshe Zhu
Department of Biotransformation, Bristol-Myers Squibb Research and Development, Princeton, New Jersey, USA
Search for more papers by this authorSeries Editor(s): Mike S. Lee,
Summary
This chapter contains sections titled:
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Relevance of AMS to Drug Metabolism
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Introduction to AMS
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Fundamentals of AMS Instruments
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Sample Definition and Interfaces
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AMS Quantitation
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LC–AMS Analysis of Drug Metabolites
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Comparative Resolution of Fraction LC Measurements
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Quantitative Extraction and Recovery
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LC–AMS Background and Sensitivity
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Clinical Aspects of AMS Metabolite Studies
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AMS Analysis of Reactive Metabolites
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Species Metabolite Comparison
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New Metabolic Studies Enabled by AMS
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Conclusions
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References
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