Chapter 15
Use of Triple Quadrupole–Linear Ion Trap Mass Spectrometry as a Single LC–MS Platform in Drug Metabolism and Pharmacokinetics Studies
Wenying Jian,
Ming Yao,
Bo Wen,
Elliott B. Jones,
Mingshe Zhu,
Wenying Jian
BA/DMPK, Pharmaceutical Research and Development, Johnson & Johnson, Raritan, New Jersey, USA
Search for more papers by this authorMing Yao
Department of Biotransformation, Bristol-Myers Squibb Research and Development, Princeton, New Jersey, USA
Search for more papers by this authorBo Wen
Department of Drug Metabolism and Pharmacokinetics, Hoffmann-La Roche, Nutley, New Jersey, USA
Search for more papers by this authorElliott B. Jones
Applied Biosystems Inc., Foster City, California, USA
Search for more papers by this authorMingshe Zhu
Department of Biotransformation, Bristol-Myers Squibb Research and Development, Princeton, New Jersey, USA
Search for more papers by this authorWenying Jian,
Ming Yao,
Bo Wen,
Elliott B. Jones,
Mingshe Zhu,
Wenying Jian
BA/DMPK, Pharmaceutical Research and Development, Johnson & Johnson, Raritan, New Jersey, USA
Search for more papers by this authorMing Yao
Department of Biotransformation, Bristol-Myers Squibb Research and Development, Princeton, New Jersey, USA
Search for more papers by this authorBo Wen
Department of Drug Metabolism and Pharmacokinetics, Hoffmann-La Roche, Nutley, New Jersey, USA
Search for more papers by this authorElliott B. Jones
Applied Biosystems Inc., Foster City, California, USA
Search for more papers by this authorMingshe Zhu
Department of Biotransformation, Bristol-Myers Squibb Research and Development, Princeton, New Jersey, USA
Search for more papers by this authorBook Editor(s):Mike S. Lee, Mingshe Zhu,
Mingshe Zhu
Department of Biotransformation, Bristol-Myers Squibb Research and Development, Princeton, New Jersey, USA
Search for more papers by this authorSeries Editor(s): Mike S. Lee,
Summary
This chapter contains sections titled:
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Introduction
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Instrumentation and Scan Functions
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In vitro and In Vivo Metabolite Profiling and Identification
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Reactive Metabolite Screening and Characterization
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In vitro Drug Interaction Studies
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Quantification and Screening of Drugs and Small Molecules
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Summary
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References
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