Brief Communication

The postmigrational development of polymicrogyria documented by magnetic resonance imaging from 31 weeks' postconceptional age

Terrie E. Inder MD

Department of Neurology, Children's Hospital and Harvard Medical School, Boston, MA

Petra S. Huppi MD

Joint Program in Neonatology, Harvard Medical School and Department of Pediatrics, University of Geneva, Geneva, Switzerland

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Gary P. Zientara PhD,

Gary P. Zientara PhD

Department of Radiology and Magnetic Resonance Imaging Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

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Ferenc A. Vjolesz MD,

Ferenc A. Vjolesz MD

Department of Radiology and Magnetic Resonance Imaging Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

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Erik E. Holling BA,

Erik E. Holling BA

Joint Program in Neonatology, Harvard Medical School and Department of Pediatrics, University of Geneva, Geneva, Switzerland

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Richard Robertson MD,

Richard Robertson MD

Division of Neuroradiology, Department of Radiology, Children's Hospital and Harvard Medical School, Boston, MA

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Patrick D. Barnes MD,

Patrick D. Barnes MD

Division of Neuroradiology, Department of Radiology, Children's Hospital and Harvard Medical School, Boston, MA

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Joseph J. Volpe MD,

Corresponding Author

Joseph J. Volpe MD

Department of Neurology, Children's Hospital and Harvard Medical School, Boston, MA

Neurology Department, Fegan 1103, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115Search for more papers by this author

Terrie E. Inder MD,

Terrie E. Inder MD

Department of Neurology, Children's Hospital and Harvard Medical School, Boston, MA

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Petra S. Huppi MD,

Petra S. Huppi MD

Joint Program in Neonatology, Harvard Medical School and Department of Pediatrics, University of Geneva, Geneva, Switzerland

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Gary P. Zientara PhD,

Gary P. Zientara PhD

Department of Radiology and Magnetic Resonance Imaging Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

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Ferenc A. Vjolesz MD,

Ferenc A. Vjolesz MD

Department of Radiology and Magnetic Resonance Imaging Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

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Erik E. Holling BA,

Erik E. Holling BA

Joint Program in Neonatology, Harvard Medical School and Department of Pediatrics, University of Geneva, Geneva, Switzerland

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Richard Robertson MD,

Richard Robertson MD

Division of Neuroradiology, Department of Radiology, Children's Hospital and Harvard Medical School, Boston, MA

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Patrick D. Barnes MD,

Patrick D. Barnes MD

Division of Neuroradiology, Department of Radiology, Children's Hospital and Harvard Medical School, Boston, MA

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Joseph J. Volpe MD,

Corresponding Author

Joseph J. Volpe MD

Department of Neurology, Children's Hospital and Harvard Medical School, Boston, MA

Neurology Department, Fegan 1103, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115Search for more papers by this author

First published: 01 June 2001

https://doi.org/10.1002/1531-8249(199906)45:6<798::AID-ANA16>3.0.CO;2-U

Citations: 31

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Abstract

We report the case of a 27-week premature infant in whom magnetic resonance imaging (MRI) at 4 postnatal weeks (postconceptional age, 31 weeks), term, and 6 months of age documented the postnatal postmigrational evolution of bilateral perisylvian polymicrogyria. The polymicrogyria was readily detected by ultrafine 1.5-mm coronal slices on three-dimensional, Fourier-transformed, spoiled gradient–recalled and T2-weighted MRI sequences. These MRI sequences provide the first in vivo documentation of the postmigrational evolution of polymicrogyria. The likelihood that the polymicrogyria was related to an ischemic encephaloclastic mechanism is supported by the simultaneous occurrence of periventricular leukomalacia. Ann Neurol 1999;45:798–801

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Volume45, Issue6

June 1999

Pages 798-801

The postmigrational development of polymicrogyria documented by magnetic resonance imaging from 31 weeks' postconceptional age

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The postmigrational development of polymicrogyria documented by magnetic resonance imaging from 31 weeks' postconceptional age

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