Lecithins
JuDong Yeo
Memorial University of Newfoundland, St. John's, Newfoundland, Canada
Search for more papers by this authorFereidoon Shahidi
Memorial University of Newfoundland, St. John's, Newfoundland, Canada
Search for more papers by this authorJuDong Yeo
Memorial University of Newfoundland, St. John's, Newfoundland, Canada
Search for more papers by this authorFereidoon Shahidi
Memorial University of Newfoundland, St. John's, Newfoundland, Canada
Search for more papers by this authorAbstract
Lecithin is a natural material with multifunctional properties. Original material was isolated from egg yolk, and it is found in significant quantities in brain and nervous tissue. Actually, lecithin is a normal constituent in all cell membranes. The main source today is found in soybeans and is commercially available in many colors, viscosities, and functionalities. This article gives a detailed description of the nature and composition of lecithin and its manufacture and uses in food as well as nonfood applications.
Lecithin has been an amphoteric surfactant for centuries but was not commercialized until soy processing started in the 1930s. It has many food applications and is also used in pharmaceutical preparations and natural food products. Lecithin has some unique properties in industrial applications, ranging from paints to fuel additives. The most prevalent use today is in chocolate and margarine manufacture and in nutritional beverages and supplements.
References
- 1Stanley, J. (1951). In: Soybeans and Soybean Products, vol. 2 (ed. K.S. Markley), 593–647. New York: Interscience Publishers, Inc.
- 2 B.F. Szuhaj (ed.) (1989). Lecithins: Sources, Manufacture, & Uses. Champaign, IL: (AOCS monograph), American Oil Chemists' Society.
- 3Szuhaj, B.F. (1983). J. Amer. Oil. Chem. Soc. 60: 258A–261A.
- 4 H. Wittcoff (ed.) (1951). The Phosphatides, American Chemical Society Monograph Series. New York: Reinhold Publishing Corp.
- 5 B.F. Szuhaj and G.R. List (ed.) (1985). Lecithins. Champaign, IL: (AOCS monograph), American Oil Chemists' Society.
- 6Szuhaj, B.F. and Sipos, E.F. (1989). In: Food Emulsifiers—Chemistry, Technology, Functional Properties and Applications (ed. G. Charalambous and G. Doxastakis), 113–186. Amsterdam, The Netherlands: Elsevier.
- 7Prosise, W.E. (1985). Lecithins, 163–182. Champaign, IL: American Oil Chemists' Society.
- 8Scholfield, C.R. (1985). Lecithins, 1–20. Champaign, IL: American Oil Chemists' Society.
- 9Wendel, A. (2000). Inform 11: 885–890, 892, 992–997.
- 10Cullis, P.R., Fenske, D.B., and Hope, M.J. (1996). Biochemistry of Lipids, Lipoproteins and Membranes: Physical Properties and Functional Roles of Lipids in Membranes, 1–33. Amsterdam, Netherlands: Elsevier.
- 11 W. Schaefer and V. Wywiol (ed.) (1986). Lecithin Der Unvergleichliche Wirkstoff. Frankfurt, Germany: Alfred Strothe Press.
- 12Kuksis, A. (1989). Lecithins: Sources, Manufacture, & Uses, 32–71. Champaign, IL: American Oil Chemists' Society.
- 13Weihrauch, J.L. and Son, Y.-S. (1983). J. Amer. Oil Chem. Soc. 60: 1971.
- 14Gornall, D.A. and Kuksis, A. (1973). J. Lipid Res. 14: 197.
- 15Schneider, M. (1989). Lecithins: Sources, Manufacture, & Uses, 109–130. Champaign, IL: American Oil Chemists' Society.
- 16Satirhos, N., Herslof, B., and Kenne, L. (1986). J. Lipid Res. 27: 386.
- 17Kuksis, A. (1985). Lecithins, 105–162. Champaign, IL: American Oil Chemists' Society.
- 18Privett, O.S., Blank, M.L., and Smith, J.A. (1962). J. Food Sci. 27: 463.
- 19Noble, R.C. and Moore, J.H. (1965). Can. J. Biochem. 43: 1677.
- 20Cook, W.H. and Martin, W.G. (1969). In: Structural and Functional Aspects of Lipoproteins in Living Systems (ed. E. Tria and A. Scanu), 579–615. New York: Academic Press, Inc.
- 21Gornall, D.A. and Kuksis, A. (1971). Can. J. Biochem. 49: 51.
- 22Connelly, P.W. and Kuksis, A. (1983). Can. J. Biochem. 61: 63.
- 23Nielsen, H. (1998). British Poultry Sci. 53–56.
- 24Morrison, W.R., Jack, E.L., and Smith, L.M. (1965). J. Amer. Oil Chem. Soc. 42: 1142.
- 25Privett, O.S., Nutter, L.J., and Gross, R.A. (ed. H.F. Brink and D. Kritchevsky) Dairy Lipids and Lipid Metabolism, 99–115. Westport, CT: Avi Publishing Co.
- 26Jensen, R.G. (2002). J. Dairy Sci. 85: 295–350.
- 27Santha, I.M. and Narayanan, K.M. (1978). J. Food Sci. Technol. 15: 24.
- 28Küllenberg, D., Taylor, L.A., Schneider, M., and Massing, U. (2012). Lipids Health Dis. 11: 3.
- 29Siakotos, A.N., Rouser, G., and Fleischer, S. (1969). Lipids 4: 239.
- 30Siakotos, A.N. and Fleischer, S. (1969). Lipids 4: 234.
- 31Scott, T.W., Setchall, B.P., and Bassett, J.M. (1967). Biochem. J. 104: 1040.
- 32Wuthier, R.E. (1966). J. Lipid Res. 7: 544.
- 33Leidl, K., Liebisch, G., Richter, D., and Schmitz, G. (2008). Biochim. Biophys. Acta 1781: 655–664.
- 34Dashiell, G.L. (1989). Lecithins: Sources, Manufacture, & Uses, 213–224. Champaign, IL: American Oil Chemists' Society.
- 35Cherry, J.P. and Kramer, W.H. (1989). In: Lecithins: Sources, Manufacture, & Uses, Chapt. 3 (ed. B.F. Szuhaj), 16–31. Champaign, IL: (AOCS monograph), American Oil Chemists' Society.
- 36Jangle, R.D., Galge, R.V., Patil, V.V., and Thorat, B.N. (2013). Indian J. Pharm. Sci. 75: 339–345.
- 37Zhu, C., Dane, A., Spijksma, G. et al. (2012). J. Chromatogr. A 13 (1220): 26–34.
10.1016/j.chroma.2011.11.034 Google Scholar
- 38Flider, F.J. (1985). Lecithins, 21–38. Champaign, IL: American Oil Chemists' Society.
- 39Weber, E.J. (1985). Lecithins, 39–56. Champaign, IL: American Oil Chemists' Society.
- 40Cherry, J.P., Gray, M.S., and Jones, L.A. (1981). J. Amer. Oil Chem. Soc. 58: 903–913.
- 41Weeks, M.E. and Walters, A. (1946). Soil Sci. Soc. Amer., Proc. 11: 189.
10.2136/sssaj1947.036159950011000C0034x Google Scholar
- 42Scholfield, C.R., McGuire, T.A., and Dutton, H.J. (1950). J. Amer. Oil Chem. Soc. 27: 352.
- 43Cherry, J.P. (1985). Lecithins, 57–78. Champaign, IL: American Oil Chemists' Society.
- 44Olcott, H.S. (1944). Science 100: 226.
- 45El-Shattory, Y.A. Studies on Cottonseed Phospholipids. Ph.D. dissertation. National Research Center, Cairo.
- 46Cherry, J.P. (1983). J. Amer. Oil Chem. Soc. 60: 360.
- 47Cherry, J.P. and Leffler, H.R. (1984). In: Cotton Monograph (ed. R.J. Kohel and C.F. Lewis), 511. Madison, WI: Am. Soc. Agron. Crop Sci. Soc. Amer.
- 48El-Sebaiy, L.A., El-Mahdy, A.R., Moustafa, E.K., and Mohamed, M.S. (1980). Food Chem. 5: 217.
- 49Rewald, B. (1937). J. Soc. Chem. Ind. 56: 403T.
- 50Hougen, F.W., Thompson, V.J., and Daun, J.K. (1985). Lecithins, 79–103. Champaign, IL: American Oil Chemists' Society.
- 51Helmerich, G. and Koehler, P. (2003). J. Agric. Food Chem. 51: 6645–6651.
- 52van Nieuwenhuyzen, W. (1999). Agro Food Industry Hi-Tech. 11–14.
- 53Sosada, M. (1993). J. Amer. Oil Chem. Soc. 70: 405–410.
- 54Morrison, W.H. (1985). Lecithins, 97–104. Champaign, IL: American Oil Chemists' Society.
- 55Hollo, J. (1992). INFORM 3 (4): 483.
- 56Carelli, A.A., Brevedan, M.I.V., and Crapiste, G.H. (1997). J. Amer. Oil Chem. Soc. 74: 511–514.
- 57Hollo, J., Peredi, J., Ruzics, A. et al. (1993). J. Amer. Oil Chem. Soc. 70 (10): 997–1001.
- 58Hilditch, T.P. and Zaky, Y.A.H. (1942). Biochem. J. 36: 815.
- 59Rewald, B. (1942). Biochem J. 36: 822.
- 60Yoshida, H., Hirakawa, Y., Tomiyama, Y. et al. (2005). J. Food Comp. Anal. 18: 3–14.
- 61Parsons, J.G. and Price, P.B. (1980). J. Agric. Food Chem. 27: 913–915.
- 62Fang, J., Barcelona, M.J., and Alvarez, P.J.J. (2000). Org. Geochem. 31: 881–887.
- 63Ratledge, C. (1989). Lecithins: Sources, Manufacture, & Uses, 72–96. Champaign, IL: American Oil Chemists' Society.
- 64Luzia, A.L., Sampaio, G.R., Castellucci, C.M.N., and Torres, E.A. (2003). Food Chem. 83: 93–97.
- 65Boselli, E., Pacetti, D., Lucci, P., and Frega, N.G. (2012). J. Agric. Food Chem. 60: 3234–3245.
- 66 Phospholipid [Def. 1] (n.d.). In Merriam Webster Online, from https://www.merriam-webster.com/dictionary/phospholipid (accessed Nov. 2019).
- 67 Committee on Food Chemicals Codex (1996). Food Chemicals Codex, 4e, 220–221. Washington, D.C: National Academy Press.
- 68Cowell, R.D., Sullivan, D.R., and Szuhaj, B.F. (1982). Surfactant Science Series, vol. 12, 230–264. New York: Marcel Dekker, Inc.
- 69Schmidt, J.C. and Orthoefer, F.T. (1985). Lecithins, 183–202. Champaign, IL: American Oil Chemists' Society.
- 70 National Soybean Processors' Association (NSPA) (1987). Yearbook and Trading Rules (1986–1987). Washington, D.C.: The Association.
- 71Van Nieuwenhuyzen, W. (1976). J. Amer. Oil Chem. Soc. 53: 425–427.
- 72 Code of Federal Regulations (1998). Title 21:172.814 (Food and Drugs). Washington, D.C.: U. S. Government Printing Office.
- 73Horrocks, L.A. (1989). Lecithins: Sources, Manufacture, & Uses, 1–6. Champaign, IL: American Oil Chemists' Society.
- 74Lantz, R.A. (1989). Lecithins: Sources, Manufacture, & Uses, 162–173. Champaign, IL: American Oil Chemists' Society.
- 75 National Soybean Processors' Association (NSPA) (1977). Yearbook and Trading Rules (1976–1977). Washington, D.C.: The Association.
- 76Szuhaj B.F. (1978). Private communication. Central Soya Co., Inc., Fort Wayne, Indiana.
- 77Rzhekhin, V.P., Pogonkina, N.I., and Sloveva, I.A. (1965). Maslob.-Zhir. Prom. 30: 11.
- 78Vijayalakshmi, B. and Rao, S.V. (1972). Lipids 9: 82.
- 79Daga, H.G.M. (1976). Indian Chem. J. 11: 17.
- 80Daga, H.G.M. (1977). Paintindia 27: 21.
- 81Rydhag, L. and Wilton, I. (1981). J. Amer. Oil Chem. Soc. 83: 830.
- 82Sullivan, D.R. and Szuhaj, B.F. (1975). J. Amer. Oil Chem. Soc. 52: 125A, abstract no. 39, presented at Amer. Oil Chem. Soc. Meeting, Dallas, Texas, April 1975.
- 83Wolf, W.J. and Cowan, J.C. (1971). CRC Crit. Rev. Food Technol. 2: 81.
10.1080/10408397109527117 Google Scholar
- 84Clark, P.K. and Snyder, H.E. (1991). J. Amer. Oil Chem. Soc. 68: 814–817.
- 85Aneja, R., Chadha, J.S., and Yoell, R.W. (1971). Fette Seifen, Anstrichm. 73: 643–651.
- 86Peterson, B.L. and Cummings, B.S. (2006). Biomed. Chromatogr. 20: 227–243.
- 87Kramer, J.K.G., Sauer, F.D., and Farnsworth, E.R. (1989). Lecithins: Sources, Manufacture, & Uses, 97–108. Champaign, IL: American Oil Chemists' Society.
- 88Ghyczy, M. (1989). Lecithins: Sources, Manufacture, & Uses, 131–144. Champaign, IL: American Oil Chemists' Society.
- 89Joshi, A., Paratkar, S.G., and Thorat, B.N. (2006). Eur. J. Lipid Sci. Technol. 108: 363–373.
- 90Totani, Y. and Hara, S. (1991). J. Am. Oil Chem. Soc. 68: 848–851.
- 91 Official Methods and Recommended Practices. American Oil Chemists' Society (AOCS). Champaign, Illinois, including Updates and Revisions up to 1993.
- 92Marmer, W.N. (1985). Lecithins, 247–288. Champaign, IL: American Oil Chemists' Society.
- 93Ackman, R.G. (1994). INFORM 5: 1119–1128.
- 94 International Lecithin and Phospholipid Society (ILPS) (1998). In: HPLC Determination of Lecithins.
- 95Glonek, T. (1998). J. Amer. Oil Chem. Soc. 75: 569–573.
- 96Scholfield, C.R. (1989). Lecithins: Sources, Manufacture, & Uses, 7–15. Champaign, IL: American Oil Chemists' Society.
- 97Baer, E. and Kates, M. (1950). J. Biol. Chem. 185: 615.
- 98Brockerhoff, H. (1963). J. Lipid Res. 4: 96.
- 99Hanahan, D.J. (1960). Lipid Chemistry. New York: Wiley.
- 100Pryde, E.H. (1985). Lecithins, 213–246. Champaign, IL: American Oil Chemists' Society.
- 101Strickland, K.P. (1973). In: Form and Function of Phospholipids (ed. G.B. Ansell, J.N. Hawthorn and R.M.C. Dawson), 9. Amsterdam: Elsevier Publishing Co.
- 102Verheij, H.M. (1974). In: Fundamentals of Lipid Chemistry (ed. R.M. Burton and F.C. Guerra), 225. Webster Groves, Missouri: BI Science Publication Division.
- 103Eichberg, J. (1981). In: Kirk-Othmer Encyclopedia of Chemical Technology, 3e, vol. 14 (ed. M. Grayson), 250–262. New York: Wiley.
- 104Hawthorn, J.N. and Kemp, P. (1964). Adv. Lipid Res. 2: 127.
- 105Kuksis, A. (1972). Prog. Chem. Fats and Other Lipids 12: 5.
10.1016/0079-6832(72)90002-X Google Scholar
- 106Snyder, F. (1971). In: Cancer Research, vol. 6 (ed. H. Busch), 410–419. New York: Academic Press, Inc.
- 107Van Deenen, L.L.M. and DeHaas, D.H. (1964). Adv. Lipid Res. 2: 167.
- 108Kanamoto, R., Ohtsuru, M., and Kito, M. (1977). Agric. Biol. Chem. 41: 2021.
- 109Beckwith, A. (1984). J. Agric. Food Chem. 32: 1397.
- 110Chen, W.S. and Soucie, W.G. (1985). J. Amer. Oil Chem. Soc. 62: 1686.
- 111Nielsen, H. (1981). Lipids 16: 215–222.
- 112K. Allen-Seabolt (1997). Central Soya Co., Inc., Ft. Wayne, Indiana.
- 113Forssell, P., Shamekh, S., Harkonen, H., and Poutanen, K. (1998). J. Sci. Food Agric. 76: 31–38.
- 114Johansson, D. and Bergenstahl, B. (1992). J. Amer. Oil Chem. Soc. 69: 705–717.
- 115Sambuc, E., Dirik, Z., Reymond, G., and Naudet, M. (1981). J. Amer. Chem. Soc. 58: 645A.
- 116Zhao, W., Yang, R., Liang, Q. et al. (2012). J. Agric. Food Chem. 60: 12204–12209.
- 117Asaduzzaman, A.K.M. and Chun, B.S. (2015). J. Ind. Engin. Chem. 21: 620–626.
- 118Pokorny, J. (1981). Rev. Fr. Corps Gras 28: 151–160.
- 119Hudson, B.J.F. and Ghavani, M. (1984). Lebensm.-Wise Technol. 17: 191–194.
- 120Hildebrand, D.H., Terao, J., and Kito, M. (1984). J. Amer. Oil Chem. Soc. 61: 552–555.
- 121Jung, U., Lee, S.-K., Kyung, S.-H. et al. (2001). Food Sci. Biotechnol. 10: 354–359.
- 122Hudson, B.J.F. and Mahgoub, S.E.O. (1981). J. Sci. Food Agric. 32: 208–210.
- 123Hudson, B.J.F. and Lewis, J.I. (1983). Food Chem. 10: 111–120.
- 124Hamilton, R.J., Kalu, C., McNeill, G.P. et al. (1998). J. Amer. Oil Chem. Soc. 75: 813–822.
- 125Saito, H. and Ishihara, K. (1997). J. Amer. Oil Chem. Soc. 74: 1531–1536.
- 126McLean, L.R., Hagaman, K.A., and Davidson, W.S. (1993). Lipids 28: 505–509.
- 127Brian, R. (1976). J. Amer. Oil Chem. Soc. 53: 27–29.
- 128List, G.R., Evans, C.D., Black, L.T., and Mounts, T.L. (1978). J. Amer. Oil Chem. Soc. 55: 275–276.
- 129List, G.R., Mounts, T.L., Warner, K., and Heakin, A.J. (1978). J. Amer. Oil Chem. Soc. 55: 277–280.
- 130Nielsen, K. (1960). J. Amer. Oil Chem. Soc. 37: 217–219.
- 131List, G.R. (1989). Lecithins: Sources, Manufacture, & Uses, 145–161. Champaign, IL: American Oil Chemists' Society.
- 132Burkhalter, J.P. (1976). J. Amer. Oil Chem. Soc. 53: 332–333.
- 133List, G.R., Avellenada, J.M., and Mounts, T.L. (1981). J. Amer. Oil Chem. Soc. 58: 892.
- 134Crauer, L.S. (1972). Paper presented at Meeting of International Society for Fat Research. Goteborg: Sweden, The DeLaval Separator Co., Poughkeepsie, New York.
- 135Bernardini, E. (1973). The New Oil and Fat Technology, reve, Technologie s.r.l., Rome, Part 3, 5, vol. 2, 505–538.
- 136Norris, F.A. (1964). In: Bailey's Industrial Oil and Fat Products, 3e (ed. D. Swern), 719–792. New York: Wiley-Interscience.
- 137Carr, R.A. (1976). J. Amer. Chem. Soc. 53: 346–352.
- 138Braae, B. (1976). J. Amer. Oil Chem. Soc. 53: 353–357.
- 139Andersen, A.J.C. (1962). In: Refining of Oils and Fats for Edible Purposes, rev (ed. P.N. Williams), 28–42. New York: Pergamon Press.
- 140Van Nieuwenhuyzen, W. (1981). J. Amer. Oil Chem. Soc. 58: 886.
- 141Sartoretto, P. (1967). In: Kirk-Othmer Encyclopedia of Chemical Technology, 2e, vol. 12 (ed. E.A. Parolla), 343–361. New York: Wiley.
- 142Klein, K. and Crauer, L.S. (1974). J. Amer. Oil Chem. Soc. 51: 368–370.
- 143Podbielniak, W.J., Gavin, A.M., and Kaiser, H.R. (1956). J. Amer. Oil Chem. Soc. 33: 24–26.
10.1007/BF02630872 Google Scholar
- 144Sullivan, F.E. (1955). J. Amer. Oil Chem. Soc. 32: 121–123.
- 145Brekke, O.L. (1980). In: Handbook of Soy Oil Processing and Utilization (ed. D.R. Erickson, E.H. Pryde, O.L. Brekke, et al.), 71–88. Champaign, IL: American Soybean Association, St. Louis, MO and American Oil Chemists' Society.
- 146List, G.R. and Erickson, D.R. (1980). Handbook of Soy Oil Processing and Utilization, 267–354. Champaign, IL: American Soybean Association, St. Louis, MO and American Oil Chemists' Society.
- 147List, G.R., King, J.W., Johnson, J.H. et al. (1993). INFORM 4: 510.
- 148Dijkstra, A.J. (1993). INFORM 4: 538.
- 149Jirjis, B., Muralidhara, H.S., and Otten, D.D. (2001). (to), US Patent 6, 207, 209, March 27.
- 150Clausen, K. (2001). Eur. J. Lipid Sci. Technol. 103: 333–340.
- 151Scholfield, C.R. and Dutton, H.J. (1954). J. Amer. Oil Chem. Soc. 31: 258.
- 152 National Oilseed Processors Assoc. 1998–1999 Yearbook and Trading Rules, Washington, DC.
- 153 National Archives and Records Administration (1983). Fed. Reg.-Library of Congress 48: 51149–51150.
- 154Leysen, R. (1979). J. Amer. Oil Chem. Soc. 56: 892A–894A.
- 155Myers, N.W. (1957). J. Amer. Oil Chem. Soc. 34: 93–96.
- 156Braae, B., Brimberg, U., and Nyman, M. (1957). J. Amer. Oil Chem. Soc. 34: 293–299.
- 157List, G.R., Mounts, T.L., Lanser, A.C., and Holloway, R.K. (1990). J. Amer. Oil Chem. Soc. 67: 867–871.
- 158List, G.R., Mounts, T.L., and Lanser, A.C. (1992). J. Amer. Oil Chem. Soc. 69: 443–446.
- 159List, G.R. and Mounts, T.L. (1993). J. Amer. Oil Chem. Soc. 70: 639–641.
- 160Zhang, F., Koseoglu, S.S., and Rhee, K.C. (1994). J. Amer. Oil Chem. Soc. 71: 1145–1148.
- 161Braae, B. (1958). Chem. Ind. (London) 36: 1152–1160.
- 162Sullivan, F.E.(1953). (to the) US Patent 2, 702, 813.
- 163Evans, C.D., List, G.R., Beal, R.E., and Black, L.T. (1974). J. Amer. Oil Chem. Soc. 51: 444–448.
- 164Ohlson, R. and Svenson, C. (1976). J. Amer. Oil Chem. Soc. 53: 8–11.
- 165Nash, A.M., Frankel, E.N., and Kwolek, W.F. (1984). J. Amer. Oil Chem. Soc. 61: 921.
- 166Ringers, H. J. (1977). (to) US Patent 4, 049, 686.
- 167Lunde, G., Landmark, L.H., and Gether, J. (1976). J. Amer. Oil Chem. Soc. 53: 207–210.
- 168Hvolby, A. (1971). J. Amer. Oil Chem. Soc. 48: 503–509.
- 169Letan, A. and Yaron, A. (1972). J. Amer. Oil Chem. Soc. 49: 702.
- 170Nielsen, K. (1956). Studies on the Nonhydratable Soybean Phosphatides. London: Trans. V. Bonde, Maxsons & Co., Ltd.
- 171Hutton, K.J. and Guymon, J.S. (2000). (to) US Patent 6, 140, 519, October 31, 2000.
- 172Wendel, A. (1995). Kirk-Othmer Encyclopedia of Chemical Technology, vol. 15, 197–201. New York: Wiley.
- 173Began, G., Manohar, B., and Sankar, K.U. (1997). Z Lebensm Unters Forsch A 205: 360–363.
- 174Hayes, L.P. and Wolff, H. (1959). (to) US Patent 2, 881, 195.
- 175Hayes, L.P. and Wolff, H. (1957). (to) US Patent 2, 792, 411.
- 176Hayes, L.P. and Wolff, H. (1957). (to) US Patent 2, 782, 216.
- 177Wolf, W.J. and Sessa, D.J. (1975). In: Encyclopedia of Food Science (ed. M.S. Peterson and A.H. Johnson), 476. Westport, CT: AVI Publishing Co.
- 178 Central Soya Co., Inc. (1994). Unpublished data, Fort Wayne, Indiana.
- 179Wittcoff, H. (1948). Hydroxyphosphatides. US Patent 2,445,948.
- 180Julian, P.L. (1953). US Patent 2, 629, 662.
- 181Haas, M.J., Scott, K., Jun, W., and Janssen, G. (1994). J. Amer. Oil Chem. Soc. 71: 483–490.
- 182Aura, A.M., Forssell, P., Mustranta, A. et al. (1994). J. Amer. Oil Chem. Soc. 71: 887–891.
- 183Juneja, L., Kazuoka, T., Koto, N. et al. (1989). Biochimica et Biophysica Acta 1003: 277–283.
- 184Svensson, I., Adlercreutz, P., and Mattiasson, B. (1990). Appl. Microbiol. Biotechnol. 33: 255–258.
- 185Haraldsson, G.G. and Thorarensen, A. (1999). J. Amer. Oil Chem. Soc. 76: 1143–1149.
- 186Betzing, H. (1969). German Patent 1, 902, 607.
- 187 Central Soya Co., Inc. (2000). The Lecithin Book. Fort Wayne, Indiana: Central Soya Co., Inc.
- 188Weete, J.D., Betageri, S., and Griffith, G.L. (1994). J. Amer. Oil Chem. Soc. 71: 731–737.
- 189Marrs, W.M., Sworn, G., and Hart, R.J. (1989). The British Food Manufacturing Industries Research Association Research Report 636, Jan. 1989.
- 190Rustom, I.Y.S., Lopez-Leival, M.H., and Nair, B.M. (1995). Int. J. Food Sci. Technol. 30: 773–781.
- 191Agboola, S.O., Singh, H., Munro, P.A. et al. (1998). J. Agric. Food Chem. 46: 1814–1819.
- 192Elnaggar, Y.S.R., El-Refaie, W.M., El-Massik, M.A., and Abdallah, O.Y. (2014). J. Control. Release 180: 10–24.
- 193Willimann, H., Walde, P., Luisi, P. et al. (1992). J. Pharm. Sci. 81: 871–874.
- 194Dashiell, G. L. and Prosise, W. E. (1984). (to) US Patent 4,479,977.
- 195Fujikawa, T.A.M. and Hamashima, M. (1979). Jpn. Kokai Tokkyo Koho, JP 83910.
- 196Madsen, J. (1987). Eur. J. Lip. Sci. Technol. 89: 165–172.
- 197Appl, R.C. (1989). Lecithins: Sources, Manufacture, & Uses, 207–212. Champaign, IL: American Oil Chemists' Society.
- 198Sinram, R.D. and Schmitt, H. (1993). INFORM 4: 509.
- 199Svanberg, L., Ahrné, L., Lorén, N., and Windha, E. (2011). J. Food Engin. 104: 70–80.
- 200Gaubert, H., Le cren, D., and Perrier, J. (1997). US Patent 5,650,188.
- 201Seabolt, A. (1997). Unpublished Data. Fort Wayne, IN: Central Soya Co., Inc.
- 202Pomeranz, Y. (1989). Lecithins: Sources, Manufacture, & Uses, 289–322. Champaign, IL: American Oil Chemists' Society.
- 203Aberham, H. (1972). Deutsche Mueller-Z 70: 228.
- 204Kuntze, R. (1972). Proceedings of the 7th International Congress on the Problems of Modern Grain Processing and Cereal Chemistry, Bergholz-Rehbruecke, pp. 73–82.
- 205Puchkova, L.I. and co-workers (1975). Izv. Vysshikh Uchebnykh Zaved. Pishchevaya Technol. 2: 68.
- 206Pyler, E.J. (1973). Baking Science and Technology, 464–485. Chicago, IL: Seibel Publishing Co.
- 207Zapryagaeva, A.V., Puchkova, L.I., Fedorova, G.S., and Chernenko, L.E. (1970). Izv. Vysshikh Uchebnykh Zav. Pischchevaya Technol. 1: 53.
- 208Krog, N. (1981). Cereal Chem. 58: 158–163.
- 209Larsson, H. and Eliasson, A.-C. (1998). J. Sci. Food Agric. 77: 552–558.
- 210Walrod, F.E. (1947). Proceedings of the 23rd Annual Meeting of the American Society of Bakery Engineers, 76.
- 211Chung, O.K., Pomeranz, Y., Hwang, E.C., and Dikeman, E. (1979). Cereal Chem. 56: 220.
- 212Chung, O.K. and Pomeranz, Y. (1977). Bakers Dig. 51: 32.
- 213Johnson, H.C., Hosney, R.C., and Varriano-Marston, E. (1979). Cereal Chem. 56: 333.
- 214Chung, O.K., Pomeranz, Y., and Finney, K.F. (1982). Cereal Chem. 59: 14.
- 215Cole, E.W., Mecham, D.K., and Pence, J.W. (1960). Cereal Chem. 37: 109.
- 216Kugimiya, M. and Donovan, J.W. (1981). J. Food Sci. 46: 765.
- 217Aura, A.-M., Forssell, P., and Mustranta, A. (1994). J. Amer. Oil Chem. Soc. 71: 887–891.
- 218van Nieuwenhuyzen, W. (1999). Eur. Food Drink Rev. 43–47.
- 219Onata, S. and co-workers Application of Enzymatic Modification of Phospholipids in Breadmaking. Am. Assoc. Cereal Chem. 69th Annual Meeting.
- 220Hampl, J. and Tvrznik, K. (1972). Proceedings of the 7th International Congress on the Problems of Modern Grain Processing and Cereal Chemistry, Bergholz-Rehbruecke, pp. 59–64.
- 221Haarasilta, S., Pullinen, T., Vaissnen, S., and Tammersalo-Karsten, I. (1991). US Patent 4,990,343.
- 222Pomeranz, Y., Shogren, M.D., and Finney, K.F. (1968). Food Technol. 22: 897.
- 223Glabe, E.F. and Anderson, P.W. (1964). Cereal Sci. Today 9: 300.
- 224Adler, L. and Pomeranz, Y. (1959). J. Sci. Food Agric. 8: 449.
10.1002/jsfa.2740100809 Google Scholar
- 225Finney, K.F., Pomeranz, Y., and Rubenthaler, G. (1963). Cereal Sci. Today 8: 166.
- 226Mizrahi, S., Berk, Z., and Kogan, U. (1965). Cereal Sci. Today 10: 45.
- 227Pomeranz, Y., Shogren, M.D., and Finney, K.F. (1969). Cereal Chem. 46: 512.
- 228Knightly, W. H. (1987). US Patent 4,684,526.
- 229Shogren, M.D., Pomeranz, Y., and Finney, K.F. (1981). Cereal Chem. 58: 142.
- 230Manley, D.J.R. (1983). Technology of Biscuits, Crackers and Cookies, 90. West Susssex, England: Ellis Horwood Ltd.
- 231Matz, S.A. (1968). Cookie and Cracker Technology, 54–55. Westport, CT: AVI Publishing Co. and 121–122.
- 232Kissel, L.T. and Yamazaki, W.T. (1975). Cereal Chem. 52: 638.
- 233Badi, S.M. and Hosney, R.C. (1976). Cereal Chem. 53: 733.
- 234Hoque, M.Z., Hossain, K.M., and Akter, F. (2009). Pakistan J. Nutr. 8: 1074–1077.
- 235Schaefer, W. (1973). Brot. 27: 132.
- 236Elsesser, C.C. and Bogyo, S.W. (1960). US Patent 2,954,297.
- 237 Central Soya Co., Inc. (2002). Technical Brochure. Fort Wayne, Indiana.
- 238Obenauf, C.F. and Tatter, C.W. (1962). US Patent 3,060,030.
- 239Sakka, H., Ikezoe, Y., and Fukuda, T. (1993). US Patent 5,196,226.
- 240Wolf, W.J. and Sessa, D.J. (1978). In: Encyclopedia of Food Technology and Food Sciences (ed. M.S. Peterson and A.H. Johnson), 461–467. Westport, CT: AVI Publishing Co., Inc.
- 241Pratt D. B. (1945). Baker's Helper, 84, 38, 64, 66, 99.
- 242 Central Soya Co., Inc. (1998). Technical brochure, Fort Wayne, Indiana.
- 243Hahn, P. W. (1993). US Patent 5,262,187.
- 244Zimmerman, E.L. (1996). US Patent 5,514,404.
- 245Gautchier, P.M. and Dyer, W. (1997). US Patent 5,626,903.
- 246Abboud, A. (1997). Canadian Patent 2,201,462.
- 247 Anonymous (1979). Cereal Foods World 24: 52.
- 248 Central Soya Co., Inc. (1993). Technical brochure, Fort Wayne, Indiana.
- 249Bily, R.R. (1981). US Patent 4,277,503.
- 250Turcot, S., Turgeon, S.L., and St.-Gelais, D. (2001). Lait 81: 429–442.
- 251Drake, M.A., Truong, V.D., and Daubert, C.R. (1999). J. Food Sci. 64: 744–747.
- 252Sipahioglu, O., Alvarez, V.B., and Solano-Lopez, C. (1999). Int. Dairy J. 9: 783–789.
- 253Pisecky, J. and Westergaard, V. (1972). Dairy Industries Int. 37: 144–147.
- 254Baldwin, A.J. and Sanderson, W.B. (1973). N. Z. J. Dairy Sci. Technol. 8: 92–100.
- 255James, M.J., Brault, M., and Coucoulas, L. (1991). Leatherhead Food R. A. Res Rep 689.
- 256Oldfield, D.J., Teehan, C.M., and Kelly, P.M. (2000). Int. Dairy J. 10: 659–667.
- 257Fonseca, C.R., Bento, M.S.G., Quintero, E.S.M. et al. (2011). Int. J. Food Sci. Technol. 46: 608–611.
- 258Singh, H., Sharma, R., and Tokley, R.P. (1992). Australian J. Dairy Technol. 47: 33–37.
- 259McCrae, C.H. (1999). Int. Dairy J. 9: 227–231.
- 260Sander, E.H. (1989). Lecithins: Sources, Manufacture, & Uses, 197–206. Champaign, IL: American Oil Chemists' Society.
- 261 Central Soya Co., Inc. (1992). Technical brochure, Fort Wayne, Indiana.
- 262Casey, J. and Campano, S. (1998). Central Soya R&D Report, Lb-15. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 263Thomas, M. (1996). Central Soya R&D Reports. Ft. Wayne, Indiana: Central Soya Co., Inc. & 1997.
- 264Casey, J. (1999). Central Soya R&D Report Lb-15. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 265Casey, J. (1993). Central Soya R&D Report. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 266Cheong, S.H. and Fischer, A. (1993). Fleischwirtschaft 73: 677–678, 681–683.
- 267Chandler, W.S., Wilkens, W.F., and Heiss, J.F. (1984). US Patent 4,434,187.
- 268Hammer, K.-D., Mans, L., and Siebrecht, M. (1996). US Patent 5,480,691.
- 269 National Academy of Sciences Food and Nutrition Board (1998). Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin and Choline, 309–422. Washington D.C.: National Academy Press.
- 270Enns, C.W., Goldman, J.D., and Cook, A. (1997). Fam. Econ. Nutr. Rev. 10: 1.
- 271Zeisel, S.H., Da Costa, K.A., Franklin, P.D. et al. (1991). FASEB J. 5: 2093–2098.
- 272Bartus, R.T., Dean, R.L., Goas, A.J., and Lippas, A.S. (1980). Science 209: 301.
- 273da Costa, K., Cochary, E.F., Blusztajn, J.K. et al. (1993). J. Biol. Chem. 268: 2100.
- 274Newberne, P.M. and Rogers, A.E. (1986). Ann. Rev. Nutr. 6: 407.
- 275Newberne, P.M., Suphiphat, V., and Locniskar, M. (1990). Nutr. Cancer 14: 175.
- 276Sheard, N.F., Tayek, J.A., Bistrian, B.R. et al. (1986). Am. J. Clin. Nutr. 43: 219.
- 277Buchman, R.L., Dubin, M., and Jenden, D. (1992). Gastroenterology 102: 1363.
- 278Lieber, C.S., DeCarli, L.M., Mak, K.M. et al. (1990). Hepatology 12: 1390.
- 279Lieber, C.S., Robins, S.J., Li, J. et al. (1994). Gastroenterology 106: 152.
- 280Macdonald, G.A. and Lucey, M.R. (1994). J. Clin. Gastroenterol 18: 274.
- 281Copeland, D.H. and Salmon, W.D. (1946). Am. J. Pathol. 22: 1059–1081.
- 282Goshal, A.K. and Farber, E. (1984). Carcinogenesis 5: 1367–1370.
- 283Locker, J., Reddy, T.V., and Lombardi, B. (1986). Carcinogenesis 7: 1309–1312.
- 284Rogers, A.E. (1995). Am. J. Clin. Nutr. 61: 659S–665S.
- 285Salmon, W.D., Copeland, D.H., and Burns, M.J. (1955). J. Natl. Cancer Inst. 15: 1549–1568.
- 286Shivapurkar, N., Wilson, M.J., Hoover, K.L. et al. (1986). J. Natl. Cancer Inst. 77: 213–217.
- 287Mikol, Y.B., Hoover, K.L., Creasia, D., and Poirier, L.A. (1983). Carcinogenesis 4: 1619–1629.
- 288Knuiman, J.T., Beynen, A.C., and Katan, M.B. (1989). Am. J. Clin. Nutr. 49: 266–268.
- 289Ridker, P.M., Stampfer, M.J., and Rifai, N. (2001). JAMA 285: 2481–2485.
- 290O'Brien, B.C. and Andrews, V.G. (1993). Lipids 28: 7–12.
- 291Wojcicki, J., Pawlik, A., Samochowiec, L. et al. (1995). Phytotherapy Res. 9: 597–599.
- 292Schneider, J., Muller, R., Buberl, W. et al. (1979). Eur. J. Clin. Pharmacol. 19: 15–19.
- 293Rampone, A. and Machida, C. (1981). J. Lipid Res. 22: 744–752.
- 294Beil, F. and Grundy, S. (1980). J. Lipid Res. 21: 525–536.
- 295Mastellone, I., Polichetti, E., Grès, S. et al. (2000). J. Nutr. Biochem. 11: 461–466.
- 296Adams, C.W.M., Bayliss, O.B., Ibrahim, M.Z.M., and Webster, M.W. (1967). J. Path. Bact. 86: 431.
- 297Friedman, M., Byers, S.O., and Rosenman, R.H. (1957). Proc. Soc. Expt. Biol. Med. 95: 586–588.
- 298Byers, S.O. and Friedman, M. (1960). J. Lipid. Res. 1: 343–348.
- 299Stanford, W.W. and Day, C.E. (1975). Artery 1: 106–114.
- 300Sirtori, C.R. (1993). Atherosclerosis Rev. 24: 175–198.
- 301Howard, A.N., Patelski, J., Bowyer, D.E., and Gresham, G.A. (1971). Atherosclerosis 14: 17–29.
- 302Adams, C.W.M., Abdulla, Y.H., Bayliss, O.B., and Morgan, R.S. (1967). J. Path. Bact. 94.
- 303Hsia, S.L., He, J.L., Nie, Y. et al. (1996). Artery 22: 1–23.
- 304Lichtenberg, L.M., Wang, A., Romero, J.J. et al. (1995). Nature Med. 1: 154.
- 305Lichtenberg, L.M., Ulloa, C., Vanous, A. et al. (1996). J. Pharmacol. Exp. Ther. 277: 1221.
- 306Albright, C.D., Friedrich, C.B., Brown, E.C. et al. (1999). Brain Res. Dev. Brain Res. 115: 123–129.
- 307Albright, C.D., Tsai, A.Y., Friedrich, C.B. et al. (1999). Brain Res. Dev. Brain Res. 113: 13.
- 308Meck, W. and Williams, C. (1997). Neuroreport 8: 3053.
- 309Meck, W. and Williams, C. (1997). Neuroreport 8: 3045.
- 310Meck, W.H. and Williams, C.L. (1999). Devel. Brain Res. 118: 51.
- 311Meck, W.H., Smith, R.A., and Williams, C.L. (1988). Dev. Psychobiol. 21: 339.
- 312Meck, W. and Williams, C. (1997). Neuroreport 8: 2831.
- 313Loy, R., Heyer, D., Williams, C.L., and Meck, W.H. (1991). Adv. Exp. Med. Biol. 295: 373.
- 314Pyapali, G., Turner, D., Williams, C. et al. (1998). J. Neurophysiol. 79: 1790.
- 315Kang, S.S., Wong, P.W.K., and Norusis, M. (1987). Metabolism 5: 458.
- 316Zeisel, S.H. (1987). In: Cellular and Molecular Basis of Cholinergic Function (ed. M.J. Dowdall and J.N. Hawthorne), 709–719. Chichester, England: Horwood Press.
- 317Zeisel, S.H., Char, D., and Sheard, N.F. (1986). J. Nutr. 116: 50–58.
- 318Ladd, S.L., Sommer, S.A., LaBerge, S., and Toscano, W. (1993). Clin. Neuropharmacol. 16: 40–49.
- 319Sitaram, N., Weingartner, H., and Gillin, J.C. (1978). Science 201 (4352): 74–76.
10.1126/science.351808 Google Scholar
- 320Spiers, P., Myers, D., Hochanadel, G. et al. (1996). Arch. Neurol. 53: 441–448.
- 321Alvarez, X.A., Laredo, M., Corzo, D. et al. (1997). Methods Find Exp. Clin. Pharmacol. 19: 201–210.
- 322Mohs, R.C., Davis, K.L., Tinklenberg, J.R., and Hollister, L.E. (1980). Neurobiol. Aging 1: 21–25.
- 323Sessa, D.J. (1985). Lecithins, 347–374. Champaign, Illinois: American Oil Chemists' Society.
- 324Heasook, K., Ho, C.-T., and Chang, S.S. (1984). J. Amer. Oil Chem. Soc. 61: 1235–1238.
- 325Stephan, A. and Steinhart, H. (2000). Eur. Food Res. Technol. 212: 17–25.
- 326Kinsella, J.E. and Damodaran, S. (1980). In: The Analysis and Control of Less Desirable Flavors in Foods and Beverages (ed. G. Charlambous), 95. New York: Academic Press, Inc.
10.1016/B978-0-12-169065-6.50012-X Google Scholar
- 327Min, D.B. and Stasinopoulos, T.G. (1985). Lecithins, 375–384. Champaign, Illinois: American Oil Chemists' Society.
- 328Sipos, E.F. (1989). In: Flavor Chemistry of Lipid Foods (ed. D.B. Min and T.H. Smouse), 265–289. Champaign, Illinois: American Oil Chemists' Society.
- 329 Stern Lecithin & Soja GmbH & Co. KG (1994). Technical brochure, Hamburg, Germany.
- 330Siwolop, S. and Eklund, C. S. (1987). Business Week (July 6) 87–88.
- 331Keller, B.C. (2001). Trends Food Sci. Technol. 12: 25–31.
- 332Mozafari, M.R., Flanagan, J., Matia-Merino, L. et al. (2006). J. Sci. Food Agric. 86: 2038–2045.
- 333Imran, M., Revol-Junelles, A.M., Paris, C. et al. (2015). LWT - Food Sci. Technol. 62: 341–349.
- 334Tai, K., Liu, F., He, X. et al. (2018). Food Res. Int. 109: 24–34.
- 335Koide, K. and Karel, M. (1987). Int. J. Food Sci. Technol. 22: 707–723.
- 336Pothakamury, U.R. and Barbosa-Canovas, G.V. (1995). Trends Food Sci. Technol. 6: 397–406.
- 337Kirby, C.J., Booker, B.E., and Law, B.A. (1987). Int. J. Food Sci. Technol. 22: 355–375.
- 338Lengerich, B.V., Haynes, L.C., Levine, H., Otterburn, M.S., Mathewson, P., and Finley, J. (1991). US Patent 4,999,208.
- 339Lindsey, D.A. (1997). Specialty Products Research Notes LEC-T-05. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 340Casey, J.N. (1997). Specialty Products Research Notes LEC-T-37. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 341Russett, J.C. (1998). Specialty Products Research Notes LEC-D-42. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 342Russett, J.C., Lindsey, D.A., and Konwinski, A. (1997). Specialty Products Research Notes LEC-T-08. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 343Russett, J.C. (1998). Specialty Products Research Notes LEC-T-43. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 344Russett, J.C. (1997). Specialty Products Research Notes LEC-T-35. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 345Casey, J.N. (1997). Specialty Products Research Notes LEC-T-36. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 346Russett, J.C. (1996). Specialty Products Research Notes LEC-A-23. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 347Coutteau, P., Geurden, I., Camara, M.R. et al. (1997). Aquaculture 155: 149.
- 348Orthorfer, F.P., Gurkin, S.U., and Fisk, J.A. (1995). Nutrition and Utilization Technology in Aquaculture, 114. Champaign, Illinois: AOCS Press.
- 349Russett, J.C. (1996). Specialty Products Research Notes LEC-S-29. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 350Davis, C.L. and Drackley, J.K. The Development, Nutrition and Management of the Young Calf. Ames, Iowa: Iowa State University Press, pp. 20, 30, 32, 227, 228.
- 351Holmes, R.F. and Kandel, C.K. (1975). South African Patent ZA7,405,866.
- 352Russett, J.C. (2000). Specialty Products Research Notes LEC-A-52. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 353Russett, J.C. (1999). Specialty Products Research Notes LEC-D-49. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 354Russett, J.C. (2002). Specialty Products Research Notes LEC-D-56. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 355Russett, J.C. (2002). Specialty Products Research Notes LEC-H-55. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 356Russett, J.C. (2002). Specialty Products Research Notes LEC-D-54. Ft. Wayne, Indiana: Central Soya Co., Inc.
- 357Canty, D., Zeisel, S., and Jolitz, A. (1996). Lecithin and Choline: Research Update on Health and Nutrition, 28. Fort Wayne, Indiana: Central Soya Company, Inc.
- 358Cox, W.R., Richie, S.J., Sifri, M. et al. (2000). 98th Annual Poultry Sciences Association Meeting Proceedings, abstract 293.
- 359Sibbald, I.R., Slinger, S.J., and Ashton, G.C. (1962). Poultry Sci. 41: 46.
- 360Polin, D. (1980). Poultry Sci. 39: 1652.
- 361Caltron, A., Sanders, D., and Brinkhaus, F. (1998). Rivista di Avicoltura 67: 36.
- 362Morales, M.A.C., Schneider, I.S., and Forster, R.J.J. (1980). Texture Sci. 12: 63.
- 363Otsuki, T. and Nagashima, K. (1975). Jpn. Kokai Tokkyo Koho JP 7545086.
- 364Beaucamp, K., Nelboeck, M., Gauhl, H. et al. (1981). German Patent DE 2,933,648.
- 365Nayler, P. (1980). European Patent Application 20,123.
- 366Bernardino, L.W. (1981). US Patent 4,297,251.
- 367 Jpn. Kokai Tokkyo Koho (1981). JP 8128298.
- 368 Takisawa and co-workers (1975). Jpn. Kokai Tokkyo Koho, JP 7570410 .
- 369Fuggini, C. and Streit, A. (1990). European Patent EP 0 374 471 A1.
- 370Szuhaj, B.F. (1980). In: World Research Conference II: Proceedings (ed. F.T. Frederick), 681–691. Boulder, Colorado: Westview Press.
- 371Evans, R., Morrison, S., and Clayton, C. (1997). PCT WO 97/31153.
- 372Foa, M. (1981). French Patent 2,475,053.
- 373Wolff, N.E. and Weigh, J.W. (1981). In: Kirk-Othmer Encyclopedia of Chemical Technology, vol. 8 (ed. M. Grayson), 794–826. New York: Wiley.
- 374McDonuogh, W.F., Montlick, J.A., and Bernard, R. (1975). US Patent 3,928,226.
- 375Friedman, H., Langmaid, R.N., and Pickart, D.E. (1968). French Patent 1,548,700.
- 376Hajduk, G., Kwoatkowsha, I., Sliwkiewicz, B. et al. (1979). Polish Patent PL 104,287.
- 377White, C. (2001). to, LLC, PCT WO 01/51706 A1.
- 378Kinsley, H. (1994). US Patent 5,328,567.
- 379Nikoloff, K. (1988). US Patent 4,766,015.
- 380Nikoloff, K. (1999). US Patent 5,858,933.
- 381Severston, S. and Coffey, M. (2001). US Patent 6,248,793 B1.
- 382Nojima, K., Shono, K., and Takahashi, M. (1987). US Patent 4,686,119.
- 383Hayes, L.P. (1974). Abstr. 945800.
- 384Hayes, L.P. and co-workers (1970). South African Patent ZA 6906125.
- 385Shimomukai, S., Fudaba, N., Omura, G., and Nakamore, Y. (1979). German Patent DE 2, 916, 494.
- 386Huang, M. (2000). US Patent 6,010,822.
- 387 Jpn. Kokai Tokkyo Koho (1980). JP 80 88, 045.
- 388Kinzli, P.E., Scott, M.A., and Morrison, A.J. (1971). German Patent DE 2,117,214.
- 389Maniar, P.N. (1971). German Patent DE 2,17,075.
- 390Newman, D.A. (1971). German Patent DE 2, 116, 902.
- 391Dabisch, W. (1970). US Patent 3,515,572, .
- 392Misato, T., Homma, Y., and Ko, K. (1977). Neth. J. Plant Pathol. 83 (Suppl. 1): 395–402.
10.1007/BF03041455 Google Scholar
- 393Esposito, J. (1989). US Patent 4,822,407.
- 394Milne, C. and Shelby, P. (1997). PCT WO 98/21945.
- 395Kalocsai, G. and co-workers (1980). Hung. Teljes 18: 326.
- 396Glass, R.L. (1988). Pesticide Biochem. Phys. 32: 93.
- 397Steurbaut, W., Megahed, H.S., Van Roey, G. et al. (ed. C.L. Foy) Adjuvants for Agrichemicals, 623–635. Ann Arbor: CRC Press.
- 398Zobitne, K. (1999). PCT WO 99/52359.
- 399 Jpn. Tokkyo Koho (1981). to, JP 8108804.
- 400Misato, T., Huang, K.T., Homma, Y. et al. (1975). US Patent 3,873,700.
- 401Homma, Y. and co-workers Nippon Noyaku Gakkaishi 6: 145–153.
- 402Burkhart, A. and Burkhart, M. (1997). US Patent 5,674,536.
- 403 Jpn Kokai Tokkyo Koho (1981). JP 81 41383.
- 404 Jpn. Kokai Tokkyo Koho (1981). JP 81140910.
- 405Ritzman, G., Etschenberg, E., Ghyczy, M., and Loehr, J. (1981). German Patent DE 3,010,041.
- 406Tuan, S.J. and Hou, R.F. (1988). J. Invert. Pathol. 52: 180–182.
- 407Degetto, A., Cappai, A., and Caprioli, V. (1991). European Patent EP 0 448 070 B1.
- 408Partelow, S. (2001). US Patent 6,300,324 B1.
- 409Rombi, M. (1989). US Patent 4,879,117.
- 410McMullen, A. I. (1974). British Patent 1, 357, 952.
- 411Paapahadjopoulos, D.P. (1979). German Patent DE 2, 907, 303.
- 412Sundaram, K.M.S., Curry, J., and Environ, J. (1996). Sci. Health B31: 1041–1060.
- 413Okauchi M. and co-workers (1976). Jpn. Kokai Tokkyo Koho, JP 76104033.
- 414Shillington, W.L. and Liggett, J.J. (1970). US Patent 3,533,810.
- 415Nisperos-Carriedo, M. and Baldwin, E. (1993). US Patent 5,198,254.
- 416Wills, R.B.H., Hopkirk, G., and Scott, K.J. (1980). J. Sci. Food Agric. 31: 663–666.
- 417Misato T. and co-workers (1976). Jpn. Kokai Tokkyo Koho JP 7622825.
- 418Watkins, C.B., Harman, J.E., and Hopkirk, G. (1988). New Zealand J. Exp. Agric. 16: 55–61.
- 419Green, C.F., Chambers, I.F., and Packe-Drury-Lowe, S.J. (1988). Ann. Appl. Biol. 113: 177–188.
- 420Miyoshi Kasei Kogyo, Y. K. (1985). Jpn. Kokai Tokkyo Koho, JP 85 190, 705.
- 421Miyoshi Kasei Kogyo, Y. K. (1985). Jpn. Kokai Tokkyo Koho, JP 85 184, 571.
- 422Kronstein, M. and Eichberg, J. (1978). Direct surface modification of pigments by plant phosphatides for their suspension in coating compounds. US Patent 4,126,591.
- 423Macchio, R., Russ, J., Slobody, B., and Tietjen, M. (1991). US Patent 5,023,075.
- 424Baker, C. (1989). Lecithins: Sources, Manufacture, & Uses, 253–260. Champaign, Illinois: American Oil Chemists' Society.
- 425Avalle, N. (1998). European Patent EP 0 882 443 A2.
- 426Pittz, E. and Smerbeck, R. (1988). US Patent 4,780,249.
- 427Kimura, K., Ofuchi, K., and Oda, K. (1987). US Patent 4,647,394.
- 428Oyama, K., Narita, T., Fujisawa, M., Tsuchiya, N., and Tsuji, M. (2002). US Patent 6,416,771 B1.
- 429Devos, J. (1990). European Patent EP 0 463 099 B1.
- 430Komerska, J., Petit, G., and Rybalka, B. (1990). US Patent 4,943,462.
- 431Roydhouse, R. (1985). European Patent Appl. EP 0 180 483 A2.
- 432Homola, A. and Dunton, R. (1999). US Patent 5,888,480.
- 433Prosise, W. (1994). US Patent 5,286,764.
- 434Ansell, G.B., Hawthorne, J.N., and Dawson, R.M.C. (1973). Form and Function of Phospholipids. New York: Elsevier.
- 435Devel, H.J. (1955). The Lipids, Their Chemistry and Biochemistry, vol. 2, 743.
- 436Retzinger G. and Deanglis A. 1999. PCT WO 99/55314.
- 437Benz, C., Papahadjopoulos, D., Park, J., Hong, K., and Kirpotin, D. (2001). US Patent 6,214,388.
- 438Kurtz, S. (2001). US Patent 6,261,597.
- 439Hope, M. and Rodrigueza, W. (2001). US Patent 6,312,719 B1.
- 440Chasalow, F. (1997). US Patent 5,703,063.
- 441Chasalow, F. (1999), US Patent 5,888,990.
- 442Chasalow, F. (2000). US Patent 6,127,349.
- 443Kohler, A., Moordian, D., and Furcht, L. (1998). US Patent 5,711,959.
- 444Purkait, B. (1999). US Patent 5,941,909.
- 445Chrai, S.S., Clawans, C., and Stupak, E. (1978). Beta-lactam-antibiotikum, seine herstellung und verwendung, German Patent DE 2, 756, 079.
- 446Ludwig, N.H. and White, W.A. (1974). US Patent 3,808,338.
- 447Gordon, M. and Wiesbach, J.A. (1973). Canadian Chem. Abstr. 932324.
- 448Yehara R. and co-workers (1980). Jpn. Kokai Tokkyo Koho JP 8449313.
- 449Bullous, G.H. (1970). British Patent 1, 182, 463.
- 450Samejima, M., Hirata, G., and Koida, Y. (1981). German Patent DE 3, 039, 908.
- 451Zeidler, J., Rosenberg, J., Neumann, J., and Breitenbach, J. (2001). US Patent 6,187,342 B1.
- 452Janoff, A., Rauch, J., and Taraschi, T. (2001). US Patent 6,261,792.
- 453Sipos, E.F. (1989). Lecithins: Sources, Manufacture, & Uses, 261–276. Champaign, Illinois: American Oil Chemists' Society.
- 454Augustin, F. and Bartling, L. (1980). US Patent 4,221,601.
- 455Kronstein, M. and Eichberg, J. (1985). US Patent 4,520,153.
- 456Aguilar-Zárate, M., Macias-Rodriguez, B.A., Toro-Vazquez, J.F., and Marangoni, A.G. (2019). Carbohydr. Polym. 205.
- 457Kronstein, M. (1978). Mod. Paint Coat. 68: 59–63.
- 458Kronstein, M. (1975). Mod. Paint Coat., Feb. 19–27.
- 459Kronstein, M. (1974). Amer. Chem. Soc., Div. Org. Coat. Plast. Chem. 34: 521–526.
- 460Kronstein, M. (1957). Paint Ind. Mag. 72 (6): 10.
- 461Kronstein, M. and Eichberg, J. (1977). US Patent 4,056,494.
- 462Kronstein, M. and Eichberg, J. (1961). US Patent 2,997,398.
- 463Kronstein, M. and Eichberg, J. (1981). US Patent 4,305,853, Dec. 15.
- 464Pardun, H. (1981). Seifen, Oele, Fatte, Wasche 107: 409–411.
- 465Eichber, J. and MacDonald, K. (1992). US Patent 5,120,357.
- 466Wissgott, U. (1996). European Patent EP 0 816 561 B1.
- 467Earidjani, R.M. and Vanlerberghe (1978). US Patent 4,217,344.
- 468Godfrey, J. (1978). US Patent 4,091,170.
- 469Wannlund, J. (1991). US Patent 5,063,090.
- 470Woodhall, E. and Kondrats, N. (1998). US Patent 5,750,190.
- 471Bakalar, M. (1998). US Patent 5,753,310.
- 472Jordan, M. (1999). US Patent 5,885,617.
- 473Grillo, S., Steffenino, R., Kunkle, D., and Saracenni, K. (1993). European Patent EP 0 527 153 B1.
- 474Woznicki, E. and Grillo, S. (1986). European Patent EP 0 321 464 B1.
- 475Amidon, G. and Crison, J. (1998). US Patent 5,851,275.
- 476Daher, L. and Sackman, L. (1992). US Patent 5,122,385.
- 477Amidon, G. and Crison, J. (1997). US Patent 5,686,133.
- 478Ittman, G., Krieg, M. (1989). US Patent 4,826,901.
- 479Zimmermann, R. (1978). US Patent 4,066,599.
- 480Zimmermann, R. (1980). US Patent 4,195,009.
- 481Hosaka, A., Okuyama, K., and Isobe, Y. (1982). German Patent DE 3, 104, 702.
- 482 Intermagnetics Corp. (1979). German Patent (Demand) FR 2, 448, 560.
- 483Kawakara, H. (1982). German Patent DE 3, 114, 646.
- 484Ohlinger, M. (1981). German Patent DE 2, 942, 646.
- 485Tamura, H. (1980). German Patent DE 3, 017, 651.
- 486Buzniak, M. (1982). Polish Patent PL 117, 092.
- 487 Jpn. Kokai Tokkyo Koho (1980). JP 80 83, 041.
- 488Chagnon, M. and Ferris, J. (1989). Lecithins: Sources, Manufacture, & Uses, 277–283. Champaign, Illinois: American Oil Chemists' Society.
- 489Williams, M. and Trahan, R. (1995). US Patent 5,413,815.
- 490Besse, M., Ross, C., and Kleaver, H. (1996). US Patent 5,587,009.
- 491Kamikaseda, T., Furudate, M., and Yamamoto, M. (1987). to, US Patent 4,634,727.
- 492Lawson, M. (1994). US Patent 5,356,466.
- 493Stewart, J. (1990). US Patent 4,948,521.
- 494Anglin, J. and Smith, D. (2001). US Patent 6,207,286 B1.
- 495Greenleaf, D., Howarth, P., and Jinks, P. (1993). PCT WO 93/14005.
- 496Brois, S., Femino, F., Deen, H., and Gutierrez, A. (1990). European Patent Application 0 386 923 A1.
- 497Vinci, J., Luciani, C., and Abbas Rizvi, S., The Lubrizol Corp. (1992). European Patent Application 0 597 712 A1.
- 498Gatt, S., Barenholz, Y., and Bercovier, H. (1992). European Patent EP 0 499 441 B1.
- 499Fava, F. and Di Gioia, D. (2001). Biotech. Bioeng. 72: 177–184.
- 500Stanley, J. (ed. M. Grayson) Kirk-Other Encyclopedia of Chemical Technology, 3e, vol. 14, 250–269.
- 501Heijkoop, A. (1972). German Patent DE 2, 213, 927.
- 502Caruso, P. P. (1981). US Patent 4,282,344.
- 503Meyer, L. (1985). US Patent 4,500,442.
- 504Leube, H. (1998). US Patent 5,767,180.
- 505Valencia, G. (1997). US Patent 5,624,975.
- 506Kuriyama, K. and Toyama, M. (1974). Jpn. Kokai Tokkyo Koho JP 74 481, 167.
- 507McAbee, M., Perkins, W., and Shomake, D. (1997). European Patent O 877 837 B1.
- 508Vlasblom, J. and Dotolo, V. (1995). US Patent 5,415,789.
- 509List, P.H. and Von Kleinsorgen, R. (1980). German Patent DE 2, 928, 040.
- 510Bove, F. (1974). US Patent 3,819,523.
- 511Manandhar, E. and Usmani, A. (1995). European Patent Application O 718 373 A1.
- 512Manandhar, E. and Usmani, A. (1998). US Patent 5,744,524.
- 513Buhlstein, R.I., Belobrov, E.A., Zilenskaya, D. et al. (1978). U. S. S. R. Patent SU 624697.
- 514Tujimito, H., Maki, T., Suganuma, S., and Sano, T. (1977). US Patent 4,049,556.
- 515Krivohlavek, D. (1998). US Patent 5,834,539.
- 516Sincroft, D. and Sipos, E. (1959). US Patent 2,987,527.
- 517Sipos, E. and Sincroft, D. (1959). US Patent 2,991,163.
- 518Meshandin, A.G., Khlebov, G.A., Shilov, I.B. et al. (1982). U.S.S.R. Patent SU 905, 236.
- 519 Official Journal of the European Communities, L339/46 (1996).
- 520EC Regulation 1139/98.
- 521Kang, S.S., Wang, P.W., and Manilow, M.R. (1992). Annu. Rev. Nutr. 12: 279–298.
- 522Boushey, C.J. et al. (1995). JAMA 274: 1049.