Totalsynthese von Epothilon E und seitenkettenmodifizierten Epothilon-Analoga durch Stille-Kupplung
K. C. Nicolaou
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road „La Jolla, CA 92037, USA, (und) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Telefax: Int.+619/784-2469
Search for more papers by this authorYun He
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road „La Jolla, CA 92037, USA, (und) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Telefax: Int.+619/784-2469
Search for more papers by this authorFrank Roschangar
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road „La Jolla, CA 92037, USA, (und) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Telefax: Int.+619/784-2469
Search for more papers by this authorN. Paul King
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road „La Jolla, CA 92037, USA, (und) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Telefax: Int.+619/784-2469
Search for more papers by this authorDionisios Vourloumis
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road „La Jolla, CA 92037, USA, (und) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Telefax: Int.+619/784-2469
Search for more papers by this authorTianhu Li
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road „La Jolla, CA 92037, USA, (und) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Telefax: Int.+619/784-2469
Search for more papers by this authorK. C. Nicolaou
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road „La Jolla, CA 92037, USA, (und) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Telefax: Int.+619/784-2469
Search for more papers by this authorYun He
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road „La Jolla, CA 92037, USA, (und) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Telefax: Int.+619/784-2469
Search for more papers by this authorFrank Roschangar
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road „La Jolla, CA 92037, USA, (und) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Telefax: Int.+619/784-2469
Search for more papers by this authorN. Paul King
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road „La Jolla, CA 92037, USA, (und) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Telefax: Int.+619/784-2469
Search for more papers by this authorDionisios Vourloumis
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road „La Jolla, CA 92037, USA, (und) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Telefax: Int.+619/784-2469
Search for more papers by this authorTianhu Li
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road „La Jolla, CA 92037, USA, (und) Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA, Telefax: Int.+619/784-2469
Search for more papers by this authorAbstract
Ringschluß durch Olefinmetathese (siehe unten, a), Abspaltung der Schutzgruppe (b), Stille-Kupplung (c) und die abschließende Epoxidierung (d) sind die wesentlichen Schritte der ersten Totalsynthese des natürlich vorkommenden Epothilons E 1. Ausgehend von dem Produkt der Olefinmetathese, einer sehr fortgeschrittenen Zwischenstufe, ist eine Fülle von Epothilon-E-Analoga mit unterschiedlichen aromatischen Resten in der Seitenkette zugänglich. TBS = tBuMe2Si.
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