Full Paper
Design and development of chiral reagents for the chromatographic e.e. determination of chiral alcohols
Willi Walther,
Thomas Netscher,
Corresponding Author
Willi Walther
Pharma Research New Technologies (W.W.) and Vitamin Research and Technology Development, F. Hoffmann-La Roche, Ltd, Basel, Switzerland
Pharma Research New Technologies (W.W.) and Vitamin Research and Technology Development, F. Hoffmann-La Roche, Ltd, Basel, SwitzerlandSearch for more papers by this authorThomas Netscher
Pharma Research New Technologies (W.W.) and Vitamin Research and Technology Development, F. Hoffmann-La Roche, Ltd, Basel, Switzerland
Search for more papers by this authorWilli Walther,
Thomas Netscher,
Corresponding Author
Willi Walther
Pharma Research New Technologies (W.W.) and Vitamin Research and Technology Development, F. Hoffmann-La Roche, Ltd, Basel, Switzerland
Pharma Research New Technologies (W.W.) and Vitamin Research and Technology Development, F. Hoffmann-La Roche, Ltd, Basel, SwitzerlandSearch for more papers by this authorThomas Netscher
Pharma Research New Technologies (W.W.) and Vitamin Research and Technology Development, F. Hoffmann-La Roche, Ltd, Basel, Switzerland
Search for more papers by this authorFirst published: 1996
Citations: 34
Abstract
(S)-Trolox methyl ether is known as a powerful chiral reagent for the e.e. determination of chiral alcohols by separation of the corresponding diastereoisomeric esters on achiral GC and SFC columns. In order to further improve his methodology, five possible candidates resultings from variation of structural elements of parent reagent have been tested for derivatization with selected alcohols and subsequent analysis of the diastereoisomeric pairs of esters. The results of this optimization procedure showing the ways to new potent reagents are discussed. © 1996 Wiley-Liss, Inc.
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