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Frontmatter (Pages: i-Xxiv)
Establishing Left–Right Patterning and Cardiac Looping (Page: 1)
Deepak Srivastava, 
CHAPTER 1
Microenvironment Provides Left–Right Instructions to Migrating Precardiac Mesoderm (Pages: 3-5)
H. Joseph Yost, 
CHAPTER 2
Calmodulin–inv Protein Interaction and Left–right Determination (Pages: 6-9)
Takahiko Yokoyama,  Yukuto Yasuhiko, 
CHAPTER 3
Misexpression of Upstream Laterality Genes on Downstream Mechanisms of Heart Looping: A Flectin Perspective (Pages: 10-13)
Kersti K. Linask,  Ming-Da Han,  YiPing Chen,  Thomas Brand,  Philip R. Brauer, 
CHAPTER 4
Pleiotropic Effects of Pitx2 Isoform C on Morphogenesis in the Mammalian Heart (Pages: 14-16)
Nigel A. Brown,  Louisa M. Jones,  Oliver A. T. Lyons,  Chengyu Liu,  Wei Liu,  Jennifer Palie,  Mei Fang Lu,  James F. Martin, 
CHAPTER 5
Signal Transduction During Cardiac Myofibrillogenesis and Looping (Pages: 17-19)
Isao Shiraishi,  Tetsuro Takamatsu,  Kenji Hamaoka, 
CHAPTER 6
Biological Role of Fibulin-2 in Cardiovascular Development (Pages: 20-23)
Takeshi Tsuda,  Mon-Li Chu, 
Mechanisms of Cardiogenesis and Myocardial Development (Page: 25)
Deepak Srivastava, 
CHAPTER 7
TBX5 Regulates Cardiac Cell Behavior During Cardiogenesis (Pages: 27-30)
Cathy J. Hatcher,  Min-Su Kim,  David Pennisi,  Yan Song,  Nata Diman,  Marsha M. Goldstein,  Takashi Mikawa,  Craig T. Basson, 
CHAPTER 8
Cardiac Homeobox Protein Csx/Nkx2.5 and its Associated Proteins (Pages: 31-36)
Hiroshi Akazawa,  Issei Komuro, 
CHAPTER 9
Regulation of Myocardium Formation after the Initial Development of the Linear Heart Tube (Pages: 37-40)
Maurice J. B. van den Hoff,  Boudewijn P. T. Kruithof,  Andy Wessels,  Roger R. Markwald,  Antoon F. M. Moorman, 
CHAPTER 10
The Role of the Extracellular Matrix (ECM) in Cardiac Development (Pages: 41-43)
Robert L. Price,  Thomas K. Borg,  James Buggy,  Wayne Carver, 
CHAPTER 11
Teratogenic Effects of Bisdiamine on the Developing Myocardium (Pages: 44-46)
Nobuhiko Okamoto,  Masao Nakagawa,  Hidetoshi Fujino,  Setsuko Nishijima,  Takashi Hanato,  Tsutomu Narita,  Kyoko Yoshida-Imanaka, 
CHAPTER 12
Proliferative Responses to Myocardial Remodeling in the Developing Heart (Pages: 47-51)
David Sedmera,  Pavel Kucera,  Frantisek Kolar,  Robert P. Thompson, 
Formation of Endocardial Cushions and Valves (Pages: 53-54)
D. Woodrow Benson, 
CHAPTER 13
TGFβ Signaling During Atrioventricular Cushion Transformation (Pages: 55-58)
Joey V. Barnett,  Jay S. Desgrosellier, 
CHAPTER 14
The Endocardium as a Unique Modulator of in Utero Cardiovascular Form and Function (Pages: 59-61)
H. Scott Baldwin,  Bin Zhou, 
CHAPTER 15
Valvulogenesis: Role of Periostin in Cushion Tissue Differentiation (Pages: 62-65)
Roger R. Markwald,  Edward L. Krug,  Stan Hoffman,  Ricardo Moreno-Rodriguez,  Laura Villavicencio,  Corey H. Mjaatvedt,  Simon J. Conway, 
CHAPTER 16
Role of Fibroblast Growth Factors in Early Valve Leaflet Formation (Pages: 66-68)
Yukiko Sugi,  Naoki Ito,  Gyorgyi Szebenyi,  John F. Fallon,  Takashi Mikawa,  Roge R. Markwald, 
CHAPTER 17
Msx1 Expression During Chick Heart Development: Possible Role in Endothelial–mesenchymal Transformation During Cushion Tissue Formation (Pages: 69-71)
Toshiyuki Yamagishi,  Yuji Nakajima,  Katsumi Ando,  Hiroaki Nakamura, 
Segment and Chamber Specification (Pages: 73-74)
D. Woodrow Benson, 
CHAPTER 18
Tbx5 Specifies the Left/Right Ventricles and Ventricular Septum Position During Cardiogenesis (Pages: 75-77)
Toshihiko Ogura, 
CHAPTER 19
Transcriptional Regulation of Ventricular Morphogenesis (Pages: 78-80)
Deepak Srivastava, 
CHAPTER 20
Fgf10 and the Embryological Origin of Outflow Tract Myocardium (Pages: 81-83)
Robert G. Kelly,  Stephane Zaffran,  Margaret Buckingham,  Nigel A. Brown, 
CHAPTER 21
Evolutionary Conservation of Atrial Natriuretic Factor(Anf) Expression, Cardiac Chamber Formation, and the Heart-forming Region (Pages: 84-87)
Antoon F. M. Moorman,  Piet A. J. De Boer,  Eric M. Small,  Paul A. Krieg,  Vincent M. Christoffels, 
Formation of Specialized Conduction Tissues (Pages: 89-90)
D. Woodrow Benson, 
CHAPTER 22
Induction and Patterning of the Impulse Conducting Purkinje Fiber Network (Pages: 91-94)
Takashi Mikawa,  Robert G. Gourdie,  Clifton P. Poma,  Maxim Shulimovich,  Christopher Hall,  Kenneth W. Hewett,  Chip Justus,  Maria Reckova,  David Sedmera,  Kimimasa Tobita,  Romulo Hurtado,  David J. Pennisi,  Nobuyuki Kanzawa,  Kimiko Takebayashi-Suzuki, 
CHAPTER 23
Spatial Correlation of Conduction Tissue in the Ventricular Trabeculae of the Developing Zebrafish (Pages: 95-97)
Norman Hu,  H. Joseph Yost,  Lance F. Barker,  Edward B. Clark, 
CHAPTER 24
Development of the Cardiac Conduction System and Contribution of Neural Crest and Epicardially Derived Cells (Pages: 98-100)
Adriana C. Gittenberger-de Groot,  Nico A. Blom,  Glenn I. Fishman,  Robert E. Poelmann, 
CHAPTER 25
The Development of the Cardiac Conduction System: An Old Story with a New Perspective (Pages: 101-104)
Andy Wessels,  Amy L. Juraszek,  Angela V. Edwards,  John B. E. Burch, 
CHAPTER 26
The Role of Calreticulin in Cardiac Development and Function (Pages: 105-106)
Kimitoshi Nakamura,  Fumio Endo,  Marek Michalak, 
Coronary Artery Development (Page: 107)
Michael Artman, 
CHAPTER 27
Development of Proximal Coronary Artery in Quail Embryonic Heart (Pages: 109-111)
Katsumi Ando,  Yuji Nakajima,  Toshiyuki Yamagishi,  Sadamu Yamamoto,  Hiroaki Nakamura, 
CHAPTER 28
Possible Roles of the Extracellular Matrix in Coronary Vasculogenesis of Mouse (Pages: 112-115)
Kyoko Imanaka-Yoshida,  Mari Hara,  Miyuki Namikata,  Keiichi Miyamoto,  Takashi Hanato,  Noriko Watanabe,  Masao Nakagawa,  Toshimichi Yoshida, 
CHAPTER 29
Abnormal Coronary Development in Bisdiamine Treated Embryo (Pages: 116-118)
Takashi Hanato,  Masao Nakagawa,  Nobuhiko Okamoto,  Setsuko Nishijima,  Hidetoshi Fujino,  Yoshihiro Takeuchi, 
Models of Congenital Cardiovascular Malformations (Pages: 119-120)
D. Woodrow Benson, 
CHAPTER 30
Deciphering the Basis for Congenital Heart Defects Using a Mouse Model of Holt–oram Syndrome (Pages: 121-124)
Benoit G. Bruneau, 
CHAPTER 31
The Role of the Transcriptional Corepressor FOG-2 in Cardiac Development (Pages: 125-127)
Eric C. Svensson,  Jeannine Wilk,  Rodney Dale,  Melinda Modrell, 
CHAPTER 32
Molecular Mechanisms Regulating Tissue-Specific Expression of Tbx1 (Pages: 128-131)
Hiroyuki Yamagishi,  Deepak Srivastava, 
CHAPTER 33
Tbx1 and Digeorge Syndrome: A Genetic Link between Cardiovascular and Pharyngeal Development (Pages: 132-134)
Huansheng Xu,  Masae Morishima,  Antonio Baldini, 
CHAPTER 34
New Insights into the Role of Tbx1 in the Digeorge Mouse Model (Pages: 135-136)
Lazaros Kochilas,  Jun Liao,  Sandra Merscher-Gomez,  Raju Kucherlapati,  Bernice Morrow,  Jonathan A. Epstein, 
Role of Neural Crest Cells in Cardiovascular Development (Pages: 137-140)
Sachiko Miyagawa-Tomita,  Makoto Nakazawa, 
CHAPTER 35
Sdf1/Cxcr4 Chemotaxisis is Disrupted within the Splotch Mouse Mutant Cardiovascular System (Pages: 141-144)
Manabu Maeda,  Jian Wang,  Rhonda Rogers,  Nurul H. Sarker,  Simon J. Conway, 
CHAPTER 36
Differences in Migration and Differentiation Capacities of Early- and Late-Migrating Cardiac Neural Crest Cells (Pages: 145-147)
Marit J. Boot,  Adriana C. Gittenberger-de Groot,  Robert E. Poelmann, 
CHAPTER 37
TGF-β2 does not affect Neural Crest Cell Migration but is a Key Player in Vascular Remodeling During Embryogenesis (Pages: 148-149)
Daniel G. M. Molin,  Marco C. Deruiter,  Thomas Doetschman,  Henry M. Sucov,  Robert E. Poelmann,  Adriana C. Gittenberger-de Groot, 
CHAPTER 38
Neural Crest Cells Contribute to Heart Formation and Cardiomyogenesis in Zebrafish (Pages: 150-152)
Mariko Sato,  H. Joseph Yost, 
Formation of Outflow Tracts (Page: 153)
Michael Artman, 
CHAPTER 39
Outflow Tract Remodeling – A Role for Tissue Polarity? (Pages: 155-157)
Deborah J. Henderson,  Helen M. Phillips, 
CHAPTER 40
Hdf-Affected Gene Fragment Revealed by Subtraction Study of HDF (Heart Defect) Mouse (Pages: 158-159)
X. Zhang,  T. Nakaoka,  Corey H. Mjaatvedt,  Roger R. Markwald,  N. Yamashita, 
Imaging Techniques (Page: 161)
Michael Artman, 
CHAPTER 41
Imaging of Heart Development in Embryos with Magnetic Resonance Microscopy (Pages: 163-165)
Bianca Hogers,  Dieter Gross,  Volker Lehmann,  Huub J. M. de Groot,  Kees Erkelens,  Adriana C. Gittenberger-de Groot,  Robert E. Poelmann, 
Cardiovascular Physiology During Development (Pages: 167-168)
Michael Artman, 
CHAPTER 42
Shear Stress in the Developing Cardiovascular System (Pages: 169-173)
Robert E. Poelmann,  Adriana C. Gittenberger-de Groot,  Bianca C. W. Groenendijk,  Beerend P. Hierck,  Bianca Hogers,  Frans T. M. Nieuwstadt,  Mathieu J. B. M. Pourquie,  Paul Steendijk,  Sandra Stekelenburg-de Vos,  Nicolette T. C. Ursem,  Jury W. Wladimiroff, 
CHAPTER 43
Quantitative Analysis for Stretch-induced Cytoskeletal Remodeling in Endothelial Cells (Pages: 174-176)
Masaaki Yoshigi,  Edward B. Clark,  H. Joseph Yost, 
CHAPTER 44
Differential Effects of Cyclic Stretch on Embryonic Ventricular Cardiomyocyte and Non-Cardiomyocyte Orientation (Pages: 177-179)
Kimimasa Tobita,  Jason B. Garrison,  Bradley B. Keller, 
CHAPTER 45
Physiology and Biomechanics of Developing Cardiovascular Systems: Expanding Frontiers (Pages: 180-185)
Bradley B. Keller, 
CHAPTER 46
Three-Dimensional fiber Architecture of the Embryonic left Ventricle During Normal Development and Reduced Mechanical Load (Pages: 186-189)
Kimimasa Tobita,  Jason B. Garrison,  Bradley B. Keller, 
CHAPTER 47
Changes in Cardiac Excitation–contraction Coupling During Mammalian Development: Implications for Regulation of Contractile Function (Pages: 190-192)
Salvatore Mancarella,  Shekhar Srivastava,  Anita Go,  Ying-Ying Zhou,  William A. Coetzee,  Michael Artman, 
CHAPTER 48
Role of the Sodium–calcium Exchanger (NCX-1) within Splotch (Sp2h) Myocardial Failure (Pages: 193-195)
Jian Wang,  Andrew Lindsley,  Tony Creazzo,  Srinagesh V. Koushik,  Simon J. Conway, 
CHAPTER 49
Sarcolipin, a Novel Regulator of Calcium Cycling, is Preferentially Expressed in the Murine and Human Atrium (Pages: 196-198)
Susumu Minamisawa,  Rumiko Matsuoka, 
CHAPTER 50
Developmental Aspects of Cardiac Sensitivity to Oxygen Deprivation: Protective Mechanisms in the Immature Heart (Pages: 199-203)
Bohuslav Ostadal,  Ivana Ostadalova,  Libor Skarka,  Frantisek Kolar,  Jan Kopecky, 
Patent Ductus Arteriosus (Pages: 205-206)
Toshio Nakanishi, 
CHAPTER 51
A Comprehensive Model for O2 Constriction in the Human Ductus Arteriosus (Pages: 207-210)
Evangelos D. Michelakis,  Bernard Thébaud,  Xi-Chen Wu,  Kyoko Hashimoto,  Rohit Moudgil,  Gwyneth Harry,  Ivan M. Rebeyka,  Stephen L. Archer, 
CHAPTER 52
Pharmacological Manipulation of the Fetal Ductus Arteriosus in the Rat (Pages: 211-214)
Kazuo Momma,  Toshio Nakanishi,  Shinichiro Imamura,  Katsuaki Toyoshima, 
CHAPTER 53
Constriction of Ductus Arteriosus by Selective Inhibition of Cyclooxygenase-1 and -2 (Pages: 215-218)
Katsuaki Toyoshima,  Atsuhito Takeda,  Shinichiro Imamura,  Kazuo Momma, 
CHAPTER 54
Synergistic Constriction of Ductus Arteriosus by Indomethacin and Dexamethasone in Fetal Rats (Pages: 219-221)
Takeshi Takami,  Kazuo Momma, 
Human Clinical Genetics and Epidemiology (Page: 223)
Deepak Srivastava, 
CHAPTER 55
Prevalence of Congenital Heart Diseases in the Czech Republic (Pages: 225-227)
Milan Šamánek, 
CHAPTER 56
Gene–environment Interactions in Congenital Heart Disease: An Epidemiological Perspective (Pages: 228-231)
Christopher A. Loffredo, 
CHAPTER 57
Familial Recurrence Risks of Congenital Heart Defects (Pages: 232-234)
M. Cristina Digilio,  Bruno Marino,  Rossella Capolino,  Anna Sarkozy,  Bruno Dallapiccola, 
CHAPTER 58
T-Box Gene Family and Congenital Cardiovascular Anomalies (Pages: 235-237)
Rumiko Matsuoka, 
CHAPTER 59
Deciphering the Genetic Etiology of Conotruncal Defects (Pages: 238-241)
Elizabeth Goldmuntz, 
CHAPTER 60
Cardiovascular Anomalies in Patients with Deletion 22q11.2: A Multicenter Study in Korea (Pages: 242-243)
In Sook Park,  Young Hwue Kim,  Jae Kon Ko,  Jung Yun Choi,  Soo Jin Kim,  Hong Ryang Kil,  June Huh,  Heung Jae Lee,  Jae Sook Ma,  Sang Bum Lee,  Eul Ju Seo,  Han Wook Yoo, 
CHAPTER 61
Atrioventricular Canal Defect: Anatomical and Genetic Characteristics (Pages: 244-247)
Bruno Marino,  Maria Cristina Digilio,  Federica Mileto,  Emanuela Conti,  Bruno Dallapiccola, 
CHAPTER 62
A Genetic Approach to Hypoplastic left Heart Syndrome (Pages: 248-252)
Paul Grossfeld, 
CHAPTER 63
Char Syndrome and TFAP2B Mutations (Pages: 253-259)
Bruce D. Gelb, 
CHAPTER 64
The Genetic Origin of Atrioventricular Conduction Disturbance in Humans (Pages: 260-262)
D. Woodrow Benson, 
CHAPTER 65
Noonan Syndrome and PTPN11 Mutations (Pages: 263-272)
Marco Tartaglia,  Bruce D. Gelb, 
CHAPTER 66
Missense Mutations in the PTPN11 as a Cause of Cardiac Defects Associated with Noonan Syndrome (Pages: 273-276)
Mitsuhiro Kamisago,  Kayoko Hirayama-Yamada,  Taichi Kato,  Shinichiro Imamura,  Kunitaka Joo,  Masahiko Ando,  Atsuyoshi Takao,  Kazuo Momma,  Makoto Nakazawa,  Rumiko Matsuoka, 
CHAPTER 67
Novel Gene Mutations in Patients with Left Ventricular Noncompaction and Evidence for Genetic Heterogeneity (Pages: 277-278)
Fukiko Ichida,  Chen Rui,  Tohru Tsuji,  Noriyuki Haneda,  Karla R. Bowles,  Shinichi Tsubata,  Keiichiro Uese,  Keiichi Hirono,  Sayaka Watanabe,  Yuji Hamamichi,  Ikuo Hashimoto,  Toshio Miyawaki,  Neil E. Bowles,  Jeffrey A. Towbin, 
CHAPTER 68
Mitochondrial 16189 DNA Variant and left Ventricular Hypertrophy in Diabetes Mellitus (Pages: 279-281)
Yukihiko Momiyama,  Michiko Furutani,  Yoshihiko Suzuki,  Shinichiro Imamura,  Kazuhiro Hosokawa,  Yoshihito Atsumi,  Kempei Matsuoka,  Mitsuru Kimura,  Hiroshi Kasanuki,  Fumitaka Ohsuzu,  Rumiko Matsuoka, 
CHAPTER 69
Mutation Analysis of BMPR2 and other Genes in Japanese Patients with Pediatric Primary Pulmonary Hypertension (Pages: 282-284)
Maya Fujiwara,  Tsutomu Saji,  Tomotaka Nakayama,  Kaoru Akimoto,  Michiko Furutani,  Shinichiro Imamura,  Atsuyoshi Takao,  Makoto Nakazawa,  Rumiko Matsuoka, 
CHAPTER 70
Pathophysiology of Williams Syndrome Arteriopathy (Pages: 285-286)
Damien Bonnet, 
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Index (Pages: 287-292)
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Color Plate (Pages: 293-320)