Chapter 19
Transcriptional Regulation of Ventricular Morphogenesis
Deepak Srivastava,
Deepak Srivastava
Search for more papers by this authorDeepak Srivastava,
Deepak Srivastava
Search for more papers by this authorBook Editor(s):Michael Artman MD, D. Woodrow Benson MD, PhD,
Deepak Srivastava MD,
Makoto Nakazawa MD,
D. Woodrow Benson MD, PhD
Professor of Pediatrics, Director, Cardiovascular Genetics, Division of Cardiology, Cincinnati Children's Hospital Medical Center
Search for more papers by this authorDeepak Srivastava MD
Pogue Distinguished Chair in Research on Cardiac Birth Defects, Joel B. Steinberg, M.D. Chair in Pediatrics Professor, Departments of Pediatrics and Molecular Biology, University of Texas, Southwestern Medical Center at Dallas
Search for more papers by this authorMakoto Nakazawa MD
Professor and Head, Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical University
Search for more papers by this authorFirst published: 01 January 2005
Summary
This chapter contains sections titled:
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Ventricular-specific DNA-binding transcription factors
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Epigenetic factors regulating ventricular development
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Summary
References
- Srivastava D, Olson EN. A genetic blueprint for cardiac development: Implications for human heart disease. Nature 2000; 407: 221–6.
- Srivastava D, Cserjesi P, Olson EN. A subclass of bHLH proteins required for cardiac morphogenesis. Science 1995; 270: 1995–9.
- Srivastava D, Thomas T, Lin Q, et al. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nat Genet 1997; 16: 154–60.
- Biben C, Harvey RP. Homeodomain factor Nkx2–5 controls left/right asymetric expression of bHLH gene eHAND during murine heart development. Genes Dev 1997; 11: 1357–69.
- Yamagishi H, Yamagishi C, Nakagawa O, et al. The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Dev Biol 2001; 239: 190–203.
- Firulli AB, McFadden DG, Lin Q, Srivastava D, Olson EN. Heart and extraembryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1. Nat Genet 1998; 18: 266–70.
- Riley P, Anson-Cartwright L, Cross JC. The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis. Nat Genet 1998; 18: 271–5.
- Riley PR, Gertsenstein M, Dawson K, Cross JC. Early exclusion of hand1-deficient cells from distinct regions of the left ventricular myocardium in chimeric mouse embryos. Dev Biol 2000; 227: 156–68.
- Christoffels VM, Habets PE, Franco D, et al. Chamber formation and morphogenesis in the developing mammalian heart. Dev Biol 2000; 223: 266–78.
- Bruneau BG, Bao ZZ, Tanaka M, et al. Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2–5 and dHand. Dev Biol 2000; 217: 266–277.
- Bao ZZ, Bruneau BG, Seidman JG, Seidman CE, Cepko CL. Regulation of chamber-specific gene expression in the developing heart by Irx4. Science 1999; 283: 161–4.
- Yelon D, Ticho B, Halpern ME, et al. The bHLH transcription factor hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development 2000; 127: 2573–82.
- Angelo S, Lohr J, Lee KH, et al. Conservation of sequence and expression of Xenopus and Zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development. Mech Dev 2000; 95: 231–7.
- Cheung P, Allis CD, Sassone-Corsi P. Signaling to chromatin through histone modifications. Cell 2000; 103: 263–71.
- Marmorstein R, Roth SY. Histone acetyltransferases: function, structure, and catalysis. Curr Opin Genet Dev 2001; 11 : 155–61.
- Khochbin S., Verdel A, Lemercier C, Seigneurin-Berny D. Functional significance of histone deacetylase diversity. Curr Opin Genet Dev 2001; 11: 162–6.
- Gottlieb PD, Pierce SA, Sims RJ, et al. Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis. Nat Genet 2002; 31: 25–32.
- Lutterbach B, Sun D, Schuetz J, Hiebert SW. The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein. Mol Cell Biol 1998; 18: 3604–11.
- Lutterbach B, Westendorf JJ, Linggi B, et al. ETO, a target of t(8;21) in acute leukemia, interacts with the N-CoR and mSin3 corepressors. Mol Cell Biol 1998; 18: 7176–84.
- Rea S, Eisenhaber F, O'Carroll D, et al. Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 2000; 406: 593–9.
