Challenges and Opportunities for Small Molecule Aptamer Development
This article is part of Special Issue:
Maureen McKeague,
Maria C. DeRosa,
Maureen McKeague
Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6, carleton.ca
Search for more papers by this authorCorresponding Author
Maria C. DeRosa
Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6, carleton.ca
Search for more papers by this authorMaureen McKeague,
Maria C. DeRosa,
Maureen McKeague
Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6, carleton.ca
Search for more papers by this authorCorresponding Author
Maria C. DeRosa
Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6, carleton.ca
Search for more papers by this authorAcademic Editor: Masayasu Kuwahara
Abstract
Aptamers are single-stranded oligonucleotides that bind to targets with high affinity and selectivity. Their use as molecular recognition elements has emerged as a viable approach for biosensing, diagnostics, and therapeutics. Despite this potential, relatively few aptamers exist that bind to small molecules. Small molecules are important targets for investigation due to their diverse biological functions as well as their clinical and commercial uses. Novel, effective molecular recognition probes for these compounds are therefore of great interest. This paper will highlight the technical challenges of aptamer development for small molecule targets, as well as the opportunities that exist for their application in biosensing and chemical biology.
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