Large-cell lymphoma with features intermediate between Hodgkin’s, primary mediastinal B-cell and grey-zone lymphoma: a conundrum on fine needle aspiration cytology
Giulio Vitagliano
Department of Medicine and Surgery, University of Naples “Federico II”, Napoli, Italy
Search for more papers by this authorPasquale Cretella
Department of Medicine and Surgery, University of Naples “Federico II”, Napoli, Italy
Search for more papers by this authorCorresponding Author
Pio Zeppa
Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno, Italy
Correspondence
Pio Zeppa, University Hospital “San Giovanni di Dio e Ruggi D’Aragona”, Largo Città d’Ippocrate 1, 84131 Salerno (SA), Italy.
Email: [email protected]
Search for more papers by this authorAlessandro Caputo
Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno, Italy
Search for more papers by this authorGiulio Vitagliano
Department of Medicine and Surgery, University of Naples “Federico II”, Napoli, Italy
Search for more papers by this authorPasquale Cretella
Department of Medicine and Surgery, University of Naples “Federico II”, Napoli, Italy
Search for more papers by this authorCorresponding Author
Pio Zeppa
Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno, Italy
Correspondence
Pio Zeppa, University Hospital “San Giovanni di Dio e Ruggi D’Aragona”, Largo Città d’Ippocrate 1, 84131 Salerno (SA), Italy.
Email: [email protected]
Search for more papers by this authorAlessandro Caputo
Department of Medicine and Surgery, University of Salerno, Baronissi, Salerno, Italy
Search for more papers by this authorAbstract
Gray zone lymphoma (GZL) is a rare B-cell lymphoma with features intermediate between diffuse Large B-Cell Lymphoma and classical Hodgkin Lymphoma. The fine-needle cytology of a GZL observed in a cervical lymph node is described and compared to the corresponding histological features. This case highlights the cytological and histological diagnostic difficulties and the need of a timely and accurate diagnosis.
CONFLICTS OF INTEREST
The authors have no conflict of interest to declare.
Supporting Information
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cyt12865-sup-0001-FigS1.pngPNG image, 161.2 KB | Fig S1 |
cyt12865-sup-0002-FigS2.jpgJPEG image, 187.1 KB | Fig S2 |
cyt12865-sup-0003-TableS1.docxWord document, 8.7 KB | Table S1 |
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REFERENCES
- 1Swerdlow SH, Campo E, Harris NL, et al. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edn. Lyon, France: International Agency for Research on Cancer; 2017.
- 2Traverse-Glehen A, Pittaluga S, Gaulard P, et al. Mediastinal gray zone lymphoma: the missing link between classic Hodgkin’s lymphoma and mediastinal large B-cell lymphoma. Am J Surg Pathol. 2005; 29(11): 1411-1421.
- 3Evens AM, Kanakry JA, Sehn LH, et al. Gray zone lymphoma with features intermediate between classical Hodgkin lymphoma and diffuse large B-cell lymphoma: characteristics, outcomes, and prognostication among a large multicenter cohort. Am J Hematol. 2015; 90(9): 778-783.
- 4Elsayed AA, Satou A, Eladl AE, Kato S, Nakamura S, Asano N. Grey zone lymphoma with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: a clinicopathological study of 14 Epstein-Barr virus-positive cases. Histopathology. 2017; 70(4): 579-594.
- 5Calaminici M, Piper K, Lee AM, Norton AJ. CD23 expression in mediastinal large B-cell lymphomas. Histopathology. 2004; 45(6): 619-624.
- 6Aussedat G, Traverse-Glehen A, Stamatoullas A, et al. Composite and sequential lymphoma between classical Hodgkin lymphoma and primary mediastinal lymphoma/diffuse large B-cell lymphoma, a clinico-pathological series of 25 cases. Br J Haematol. 2020; 189(2): 244-256.
- 7Vigliar E, Cozzolino I, Fernandez LV, et al. Fine-needle cytology and flow cytometry assessment of reactive and lymphoproliferative processes of the breast. Acta Cytol. 2012; 56(2): 130-138.
- 8Zeppa P, Varone V, Cozzolino I, Salvatore D, Vetrani A, Palombini L. Fine needle cytology and flow cytometry of ectopic cervical thymoma: a case report. Acta Cytol. 2010; 54(5 Suppl): 998-1002.
- 9Cozzolino I, Vitagliano G, Caputo A, et al. CD15, CD30, and PAX5 evaluation in Hodgkin's lymphoma on fine-needle aspiration cytology samples. Diagn Cytopathol. 2020; 48(3): 211-216.
- 10Cozzolino I, Vigliar E, Sosa Fernandez LV, et al. Non lymphomatous clonal B-cell populations in enlarged lymph nodes in acquired immunodeficiency syndrome. Infez Med. 2012; 20(Suppl 2): 35-42.
- 11Cozzolino I, Zeppa R, Zeppa P. Lymph nodal Merkel cell carcinoma: primary tumor or metastasis from unknown primary site? J Cutan Pathol. 2011; 38: 836-837.
- 12Nadeem O, Treaba DO, Castillo JJ, Butera JN. Grey zone lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma: better results with CHOP-like regimens. Blood. 2013; 122: 5105.
- 13Pilichowska M, Kritharis A, Evens AM. Gray-zone lymphoma: current diagnosis and treatment options. Hematol Oncol Clin North Am. 2016; 30(6): 1251-1260.
- 14Mottok A, Wright G, Rosenwald A, et al. Molecular classification of primary mediastinal large B-cell lymphoma using routinely available tissue specimens. Blood. 2018; 132(22): 2401-2405.
- 15Dunleavy K, Wilson WH. Primary mediastinal B-cell lymphoma and mediastinal gray zone lymphoma: do they require a unique therapeutic approach? Blood. 2015; 125(1): 33-39.
- 16Sarkozy C, Molina T, Ghesquières H, et al. Mediastinal grey zone lymphoma. Clinico-pathological characteristic and outcomes of 99 patients from the lymphoma study association. Haematologica. 2017; 102: 150-159.
- 17Barroca H, Bode-Lesniewska B, Cozzolino I, Zeppa P. Management of cytologic material, preanalytic procedures and biobanking in lymph node cytopathology. Cytopathology. 2019; 30: 17-30.
- 18Peluso AL, Ieni A, Mignogna C, Zeppa P. Lymph node fine-needle cytology: beyond flow cytometry. Acta Cytol. 2016; 60(4): 372-384.
- 19Cozzolino I, Varone V, Picardi M, et al. CD10, BCL6, and MUM1 expression in diffuse large B-cell lymphoma on FNA samples. Cancer Cytopathol. 2016; 124(2): 135-143.
- 20Cozzolino I, Vigliar E, Todaro P, et al. Fine needle aspiration cytology of lymphoproliferative lesions of the oral cavity. Cytopathology. 2014; 25: 241-249.