Relationships between fasting glucose levels, lifestyle factors, and metabolic parameters in Korean adults without diagnosis of diabetes mellitus
未诊断糖尿病的韩国成年人空腹血糖水平、生活方式因素和代谢参数之间的关系
Abstract
enBackground
We investigated the associations between fasting glucose level ranges with lifestyle factors and metabolic profiles among adults without previous diagnosis of diabetes.
Methods
We analyzed 13 625 adults without previous diagnosis of diabetes from the Korea National Health and Nutrition Examination Survey during 2016 to 2018. We categorized fasting glucose levels (mg/dl) as follows: <90, 90 to 99, 100 to 109, 110 to 124, and ≥125. We evaluated trends in the proportions of individuals with obesity, abdominal, obesity, current smoking, heavy drinking, and low physical activity according to these categories, and the odds for uncontrolled blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C) for each fasting glucose level compared to a fasting glucose level of <90 mg/dl.
Results
The proportions of individuals with obesity, abdominal obesity, and heavy drinking increased according to fasting glucose level (P for trend <.05). The odds for BP ≥140/90 mm Hg, TG ≥150 mg/dl, HDL-C < 40 mg/dl in men, and HDL-C < 50 mg/dl in women increased with increasing fasting glucose levels; however, the odds for LDL-C ≥ 130 mg/dl increased with increasing fasting glucose levels only in women. The increases in odds for uncontrolled BP and lipid profiles were mostly observed for fasting glucose levels ≥90 mg/dl.
Conclusions
Efforts are needed to prevent increased fasting glucose levels, as higher levels, even within normal range, were associated with poor metabolic profiles.
摘要
zh背景
在未诊断为糖尿病的成年人中, 我们调查了空腹血糖水平范围与生活方式因素和代谢特征之间的关系
方法
我们分析了2016-2018年韩国国家健康和营养检查调查(Korea National Health And Nutrition Examination Survey)中13,625名之前未诊断糖尿病的成年人。我们将空腹血糖水平(mg/dL)分类如下:<90、90-99、100-109、110-124和≥125。我们根据这些类别评估了肥胖、腹部肥胖、当前吸烟、酗酒和低体力活动的个体比例的趋势, 以及与空腹血糖水平<90 mg/dL相比, 每种空腹血糖水平不受控制的血压(BP)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)和高密度脂蛋白胆固醇(LDL-C)的几率。
结果
肥胖、腹型肥胖和大量饮酒的比例随着空腹血糖水平的升高而增加(p<0.05)。男性BP140/90 mmHg、TG≥150 mg/dL、HDL-C<40 mg/dL和女性HDL-C<50 mg/dL的发生几率随空腹血糖水平的升高而增加, 而LDL-C≥130 mg/dL的发生几率仅在女性中随空腹血糖水平的升高而增加。不受控制的血压和血脂的发生几率增加主要在空腹血糖水平≥90 mg/dL时观察到。
结论
需要尽可能防止空腹血糖水平升高, 因为更高的水平, 即使在正常范围内, 也与较差的代谢谱相关。
