Negative association between serum aryl hydrocarbon receptor concentrations and β-cell function in patients with no history of diabetes undergoing coronary angiography
在曾接受冠状动脉造影但无糖尿病史的患者中血清芳香烃受体浓度与β细胞功能呈负相关
Abstract
enBackground
The aim of the present study was to investigate the association between serum aryl hydrocarbon receptor (AhR) levels and insulin resistance and β-cell function in patients undergoing coronary angiography with no history of diabetes.
Methods
Patients with no history of diabetes who had undergone coronary angiography underwent an oral glucose tolerance test (OGTT) 2–4 weeks after discharge from hospital; blood samples were collected for measurements of glucose, insulin, and AhR. Patients’ glucose regulation status was determined on the basis of the OGTT. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). β-Cell function was assessed using the insulinogenic index (IGI).
Results
The study included 473 patients (mean (±SD) age 61 ±12 years, 81.8% male, mean body mass index 26.1 ±3.6 kg/m2). Overall, mean serum AhR concentrations were 25.1 ±12.2 pg/mL. Patients with normal glucose tolerance had a lower serum AhR concentrations than patients with prediabetes or newly diagnosed diabetes (23.4 ±10.8 vs 26.2 ±13.2 and 26.9 ±12.3 pg/mL, respectively; P = 0.029). Linear regression analysis revealed that serum AhR concentrations were not associated with HOMA-IR, but were negatively associated with IGI after adjustment for several confounders, including HOMA-IR (β = −0.162; 95% confidence interval − 0.302, −0.022; P = 0.023).
Conclusions
In patients with no history of diabetes, serum AhR concentrations were negatively associated with β-cell function, independent of several confounders, including insulin resistance.
Abstract
zh摘要
背景
本研究旨在曾接受冠状动脉造影但无糖尿病史的患者中分析血清芳香烃受体浓度(aryl hydrocarbon receptor, AhR)与胰岛素抵抗及β细胞功能的相关性。
方法
接受冠状动脉造影的无糖尿病史的患者在出院2-4周后进行口服葡萄糖耐量试验(OGTT——, 收集血液样本用于检测血糖、胰岛素及AhR。根据OGTT的结果区分患者的葡萄糖耐受状况。利用胰岛素抵抗稳态模型(homeostasis model assessment of insulin resistance, HOMA-IR)评估胰岛素抵抗。利用胰岛素生成指数(insulinogenic index, IGI)评估β细胞功能。
结果
本研究共纳入473位患者(平均年龄 [±标准差]为61 ± 12岁, 81.8%为男性, 平均身体质量指数为26.1 ± 3.6 kg/m2)。平均血清AhR浓度为25.1 ± 12.2 pg/mL)。葡萄糖耐受正常者的血清AhR浓度比糖尿病前期或新诊断糖尿病患者低(分别为23.4 ± 10.8 vs. 26.2 ± 13.2 vs. 26.9 ± 12.3 pg/mL, P = 0.029)。线性回归分析显示, 血清AhR浓度与HOMA-IR无显著相关性, 但与IGI呈显著负相关;即使校正一些混杂因素(包括HOMA-IR)后, 该负相关依然存在(β = -0.162, 95%置信区间:-0.302, -0.022, P = 0.023)。
结论
在没有糖尿病史的患者中, 血清AhR浓度与β细胞功能呈显著负相关, 该相关性独立于包括胰岛素抵抗在内的一些混杂因素。
