Volume 10, Issue 11 pp. 899-901

Research Letter

Open Access

Skin autofluorescence, a non-invasive biomarker for advanced glycation end products, is not related to the number of pregnancies

皮肤自发荧光强度是一种非侵入性的晚期糖基化终末产物的生物标志物, 与妊娠次数无关

Robert P. Van Waateringe,

Robert P. Van Waateringe

Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Search for more papers by this author

Laura Truyens,

Laura Truyens

University of Louvain, Louvain, Belgium

Search for more papers by this author

Paul P. Van Den Berg,

Paul P. Van Den Berg

Department of Gynecology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Search for more papers by this author

Helen L. Lutgers,

Helen L. Lutgers

Department of Internal Medicine, Medisch Centrum Leeuwarden, Leeuwarden, The Netherlands

Search for more papers by this author

Bruce H.R. Wolffenbuttel,

Corresponding Author

Bruce H.R. Wolffenbuttel

[email protected]

orcid.org/0000-0001-9262-6921

Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Correspondence

Bruce H.R. Wolffenbuttel, Department of Endocrinology, University Medical Center Groningen, HPC AA31, P.O. Box 30001, 9700 RB Groningen, The Netherlands.

Tel: +31 50 3613962

Fax: +31 50 3619392

Email: [email protected]

Search for more papers by this author

Robert P. Van Waateringe,

Robert P. Van Waateringe

Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Search for more papers by this author

Laura Truyens,

Laura Truyens

University of Louvain, Louvain, Belgium

Search for more papers by this author

Paul P. Van Den Berg,

Paul P. Van Den Berg

Department of Gynecology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Search for more papers by this author

Helen L. Lutgers,

Helen L. Lutgers

Department of Internal Medicine, Medisch Centrum Leeuwarden, Leeuwarden, The Netherlands

Search for more papers by this author

Bruce H.R. Wolffenbuttel,

Corresponding Author

Bruce H.R. Wolffenbuttel

[email protected]

orcid.org/0000-0001-9262-6921

Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

Correspondence

Bruce H.R. Wolffenbuttel, Department of Endocrinology, University Medical Center Groningen, HPC AA31, P.O. Box 30001, 9700 RB Groningen, The Netherlands.

Tel: +31 50 3613962

Fax: +31 50 3619392

Email: [email protected]

Search for more papers by this author

First published: 17 May 2018

https://doi.org/10.1111/1753-0407.12782

Share a link

Email
Wechat
Bluesky

Abstract

Highlights

Skin autofluorescence (SAF) assesses subcutaneous accumulation of advanced glycation end products and has been shown to predict future cardiovascular disease and diabetes.
A higher number of pregnancies was significantly associated with higher SAF, even after correction for relevant confounders like waist circumference, creatinine clearance, and diabetes status, but not after correction for age.
Women with the highest SAF Z-score had a more unfavorable risk factor profile, with higher body mass index and waist circumference, higher blood pressure, lower high-density lipoprotein cholesterol, and higher triglyceride levels.

Supporting Information

References

1Toescu V, Nuttall SL, Martin U, Kendall MJ, Dunne F. Oxidative stress and normal pregnancy. Clin Endocrinol (Oxf). 2002; 57: 609–613.
10.1046/j.1365-2265.2002.01638.x
CAS PubMed Web of Science® Google Scholar
2De Ranitz-Greven WL, Kaasenbrood L, Poucki WK et al. Advanced glycation end products, measured as skin autofluorescence, during normal pregnancy and pregnancy complicated by diabetes mellitus. Diabetes Technol Ther. 2012; 14: 1134–1139.
10.1089/dia.2012.0120
CAS PubMed Web of Science® Google Scholar
3Meerwaldt R, Graaff R, Oomen PHN et al. Simple non-invasive assessment of advanced glycation endproduct accumulation. Diabetologia. 2004; 47: 1324–1330.
10.1007/s00125-004-1451-2
CAS PubMed Web of Science® Google Scholar
4Blaauw J, Smit AJ, van Pampus MG et al. Skin autofluorescence, a marker of advanced glycation end products and oxidative stress, is increased in recently preeclamptic women. Am J Obstet Gynecol. 2006; 195: 717–722.
10.1016/j.ajog.2006.06.086
PubMed Web of Science® Google Scholar
5Coffeng SM, Blaauw J, Souwer ET et al. Skin autofluorescence as marker of tissue advanced glycation end-products accumulation in formerly preeclamptic women. Hypertens Pregnancy. 2011; 30: 231–242.
10.3109/10641955.2010.484085
CAS PubMed Web of Science® Google Scholar
6Jacobs MB, Kritz-Silverstein D, Wingard DL, Barrett-Connor E. The association of reproductive history with all-cause and cardiovascular mortality in older women: The Rancho Bernardo Study. Fertil Steril. 2012; 97: 118–124.
10.1016/j.fertnstert.2011.10.028
PubMed Web of Science® Google Scholar
7Parikh NI, Lloyd-Jones DM, Ning H et al. Association of number of live births with left ventricular structure and function. The Multi-Ethnic Study of Atherosclerosis (MESA). Am Heart J. 2012; 163: 470–476.
10.1016/j.ahj.2011.12.011
PubMed Web of Science® Google Scholar
8Ahmed R, Dunford J, Mehran R, Robson S, Kunadian V. Pre-eclampsia and future cardiovascular risk among women a review. J Am Coll Cardiol. 2014; 63: 1815–1822.
10.1016/j.jacc.2014.02.529
PubMed Web of Science® Google Scholar

Volume10, Issue11

November 2018

Pages 899-901

Skin autofluorescence, a non-invasive biomarker for advanced glycation end products, is not related to the number of pregnancies

皮肤自发荧光强度是一种非侵入性的晚期糖基化终末产物的生物标志物, 与妊娠次数无关

Abstract

Supporting Information

References

Figures

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Skin autofluorescence, a non-invasive biomarker for advanced glycation end products, is not related to the number of pregnancies

皮肤自发荧光强度是一种非侵入性的晚期糖基化终末产物的生物标志物, 与妊娠次数无关

Abstract

Supporting Information

References

Figures

References

Related

Information