High dietary intake of branched-chain amino acids is associated with an increased risk of insulin resistance in adults
成年人饮食中高支链氨基酸摄入量与胰岛素抵抗风险增加相关
Abstract
enBackground
The aim of this study was to investigate the association between branched-chain amino acid (BCAA) intake and markers of insulin metabolism in adults.
Methods
This cohort study was conducted within the framework of the Tehran Lipid and Glucose Study on 1205 subjects, aged ≥20 years, who were followed-up for a mean of 2.3 years. Dietary intake of BCAAs, including valine, leucine, and isoleucine, was determined using a valid and reliable food frequency questionnaire. Hyperinsulinemia, β-cell dysfunction, insulin resistance (IR), and insulin insensitivity were determined according to optimal cut-off values. Logistic regression was to estimate the occurrence of IR across tertiles of BCAA intake.
Results
The mean (± SD) age and BCAA intake of participants (43% male) at baseline were 42.7 ± 13.1 years and 13.8 ± 5.1 g/day, respectively. The incidence of hyperinsulinemia, β-cell dysfunction, insulin insensitivity, and IR was 19.5%, 24.0%, 28.0%, and 12.5%, respectively. After adjustment for confounding variables, subjects in the highest tertile for total BCAAs (odds ratio [OR] 1.67; 95% confidence interval [CI] 1.03–2.71), leucine (OR 1.75; 95% CI 1.09–2.82), and valine (OR 1.61; 95% CI 1.01–2.60) intake had a greater risk of incident IR than subjects in the lowest tertile. A higher intake of isoleucine was not associated with risk of incident IR. There was no association of total BCAAs, leucine, isoleucine, and valine intake with the risk of hyperinsulinemia, insulin insensitivity, or β-cell dysfunction.
Conclusion
The findings of this study support the hypothesis that higher intakes of BCAAs may have adverse effects on the development of IR.
Abstract
zh摘要
背景
当前这项研究的目的是在成年人中调查支链氨基酸(branched-chain amino acid,BCAA)摄入量与胰岛素代谢标志物之间的关系。
方法
这项队列研究是在德黑兰血脂与血糖研究体系内进行的, 纳入了1205名年龄> 20岁的受试者, 平均随访时间为2.3年。使用有效可靠的食物频率问卷表来测定饮食中的BCAAs摄入量, 包括缬氨酸、亮氨酸与异亮氨酸。根据最佳切点来确定高胰岛素血症、β细胞功能障碍、胰岛素抵抗以及胰岛素不敏感。使用logistic回归分析来评估胰岛素抵抗发生率与BCAA摄入量三分位组的关系。
结果
基线时参与者(43%为男性)的平均(± SD)年龄以及BCAA摄入量分别为42.7 ± 13.1岁与13.8 ± 5.1克/日。高胰岛素血症、β细胞功能障碍、胰岛素不敏感以及胰岛素抵抗的发生率分别为 19.5%、24.0%、28.0%与12.5%。经过混淆变量的校正之后, 与处于最低三分位组的受试者相比, 总BCAAs(优势比[OR]为1.67;95%置信区间[CI]为1.03-2.71)、亮氨酸(OR为1.75;95% CI为1.09-2.82)以及缬氨酸(OR为1.61;95% CI为1.01-2.60)摄入量处于最高三分位组的受试者发生胰岛素抵抗的风险更高。高异亮氨酸摄入量与发生胰岛素抵抗风险之间没有相关性。总BCAAs、亮氨酸、异亮氨酸以及缬氨酸的摄入量与高胰岛素血症、胰岛素不敏感或者β细胞功能障碍风险之间没有相关性。
结论
这项研究结果支持以下假说, 亦即高BCAAs摄入量可能会对胰岛素抵抗的发生造成不良影响。
