Cover Image, Volume 89, Issue 12

Front Cover: The cover image has been created by Clemens Meyer and Adam Cain from DeepMind. It shows the ground truth experimental structure for CASP14 target T1044 in green, together with the prediction of the AlphaFold2 team in blue.Target T1044 (PDB 6VR4) is the RNA polymerase of the crAss-like phage phi14:2, a large single-chain protein with 2180 residues. Its structure was published by Drobysheva et al. (Nature, 2020). Target T1044 was split into 9 domains for the CASP14 experiment (T1031, T1033, T1035, T1037, T1039, T1040, T1041, T1042, and T1043); a prediction for the full protein chain, including domain packing, is shown here.